Abstract:
BACKGROUND:Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptide-based therapeutic vaccine candidate corresponding to C5/gp41732-744 as well as the effects on pre-existing AB levels to C5/gp41732-744, immune activation and T cell responses including exploratory assessments of Vacc-C5-induced T cell regulation. Our hypothesis was that exposure of the C5 peptide motif may have detrimental effects due to several of its HLA-like features and that enhancement of non-neutralising anti-C5 AB by vaccination could reduce C5 exposure and thereby chronic immune activation. METHODS:Thirty-six HIV patients on effective antiretroviral therapy were randomised to one of three dose levels of Vacc-C5 administered intramuscularly with Alhydrogel or intradermally with GM-CSF as adjuvant through initial immunisation and two booster periods over 26 weeks. Vacc-C5-specific AB were measured by ELISA and T cell responses by both IFN-γ ELISPOT and proliferative assays analysed by flow cytometry. Immune regulation was assessed by functional blockade of the two inhibitory cytokines IL-10 and TGF-β in parallel cultures. Non-parametric statistical tests were applied. RESULTS:Vacc-C5 was found safe and well tolerated in all patients. Only marginal changes in humoral and cellular responses were induced, without any effect on immune activation. Overall, anti-Vacc-C5 AB levels seemed to decrease compared to pre-existing levels. Whereas Vacc-C5-specific CD8+ T cell proliferative responses increased after the first booster period (p = 0.020; CD4+, p = 0.057), they were reduced after the second. In contrast, Vacc-C5-induced T cell regulation increased after completed vaccination (p ≤ 0.027) and was lower at baseline in the few AB responders identified (p = 0.027). CONCLUSIONS:The therapeutic HIV vaccine candidate Vacc-C5 safely induced only marginal immune responses, whereas Vacc-C5-induced T cell regulation markedly increased. Our data support further attention on immune regulation during therapeutic HIV vaccination studies. TRIAL REGISTRATION:NCT01627678 .
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Brekke K,Sommerfelt M,Ökvist M,Dyrhol-Riise AM,Kvale Ddoi
10.1186/s12879-017-2316-xsubject
Has Abstractpub_date
2017-03-24 00:00:00pages
228issue
1issn
1471-2334pii
10.1186/s12879-017-2316-xjournal_volume
17pub_type
杂志文章,随机对照试验abstract:BACKGROUND:More detailed understanding of herpes zoster (HZ) is called for in the context of an increasing observed frequency of disease, and ongoing discussions regarding potential consequences of the disease. Thus, population-based data on incidence and complications of HZ are needed. METHODS:We conducted a register...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1170-y
更新日期:2015-10-31 00:00:00
abstract:BACKGROUND:The risk of life-threatening and invasive infections with encapsulated bacteria is increased in patients with hyposplenia or asplenia. We report a case of recurrent invasive pneumococcal meningitis in a woman with previous unknown hyposplenia. She was vaccinated after the first episode of meningitis and deve...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0883-2
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:During weeks 32-33, 2013, 24 cases of cryptosporidiosis were notified in the city of Halle (annual mean 2008-2012: 9 cases). We investigated the outbreak to identify the source and recommend control measures, considering that between weeks 23-25 the river Saale which flows through the city centre overflowed ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0807-1
更新日期:2015-02-22 00:00:00
abstract:BACKGROUND:The C - reactive protein (CRP) response is often measured in patients with active tuberculosis (TB) yet little is known about its relationship to clinical features in TB, or whether responses differ between ethnic groups or with different Mycobacterium tuberculosis (M.tb) strain types. We report the relation...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1612-1
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Qinghai-Tibetan Plateau of China is known to be the plague endemic region where marmot (Marmota himalayana) is the primary host. Human plague cases are relatively low incidence but high mortality, which presents unique surveillance and public health challenges, because early detection through surveillance ma...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-382
更新日期:2014-07-10 00:00:00
abstract:BACKGROUND:The management of disseminated cysticercosis is unclear and largely considered hazardous. The role of albendazole remains controversial in such patients. METHODS:A tertiary care, University hospital-based prospective intervention study was conducted from December 2015 to December 2017. Patients with dissemi...
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pub_type: 杂志文章
doi:10.1186/s12879-020-4891-5
更新日期:2020-03-14 00:00:00
abstract:BACKGROUND:Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS:A review of neonatal blood cultures submitted to the microb...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1913-4
更新日期:2016-10-24 00:00:00
abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-32
更新日期:2008-03-06 00:00:00
abstract:BACKGROUND:Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China. METHODS:This is a cross-sectional and hospital-based study. From June 201...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3032-x
更新日期:2018-03-15 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-116
更新日期:2010-05-13 00:00:00
abstract:BACKGROUND:Myocarditis can develop as a complication of various infections and is most commonly linked to enterovirus infections. Myocarditis is rarely associated with bacterial infections; salmonellosis and shigellosis have been the most frequently reported bacterial cause. We report a case of myocarditis related to C...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-3-16
更新日期:2003-07-17 00:00:00
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journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2334-13-22
更新日期:2013-01-19 00:00:00
abstract:BACKGROUND:In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all doubl...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0769-3
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:Surgical site infections following coronary artery bypass graft (CABG) procedures pose substantial burden on patients and healthcare systems. This study aims to describe the incidence of surgical site infections and causative pathogens following CABG surgery over the period 2003-2012, and to identify risk fa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-318
更新日期:2014-06-10 00:00:00
abstract:BACKGROUND:Enterovirus 71 (EV-A71) shows a potential of rapid death, but the natural history of the infection is poorly known. This study aimed to examine the natural history of EV-A71 infection. METHODS:This was a prospective longitudinal observational study performed between January 1st and October 31st, 2012, at th...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-017-2228-9
更新日期:2017-02-17 00:00:00
abstract:BACKGROUND:Resistance to carbapenem antibiotics is emerging worldwide among Enterobacteriaceae. To prevent hospital transmission due to unnoticed carriage of carbapenemase producing micro-organisms in newly admitted patients, or follow-up of patients in an outbreak setting, a molecular screening method was developed fo...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-14-27
更新日期:2014-01-14 00:00:00
abstract:BACKGROUND:Recent evidence indicates that Gram-negative bacterial pathogens, the most common of which are Pseudomonas spp., Enterobacteriaceae, and Acinetobacter baumannii, are frequent causes of hospital-acquired infections. This study aims to evaluate the in vitro activity of doripenem and comparator carbapenem antib...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-42
更新日期:2012-02-16 00:00:00
abstract:BACKGROUND:On 18 August 2015, Kyegegwa District reported eight deaths during a measles outbreak to the Uganda Ministry of Health (MoH). We investigated this death cluster to verify the cause, identify risk factors, and inform public health interventions. METHODS:We defined a probable measles case as onset of fever and...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2558-7
更新日期:2017-07-03 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-111
更新日期:2005-12-12 00:00:00
abstract:BACKGROUND:A rare phenotype of clinical non-progressors to AIDS is not well understood and the new protocol for universal treatment, may block the understanding of viral control thus it is crucial to define this controversial group. METHODS:A cohort of 30 persons followed a criteria for viremia control groups 1 (VC1; ...
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pub_type: 杂志文章
doi:10.1186/s12879-017-2491-9
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community acquired pneumonia (CAP). Establishing an early diagnosis of M. pneumoniae pneumonia in patients with acute respiratory distress syndrome (ARDS) may have important therapeutic implications. METHODS:We describe diagnosis and ...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05085-5
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abstract:BACKGROUND:Tuberculosis (TB) continues to be a public health challenge in Saudi Arabia, particularly for the elderly. This study was conducted to estimate mortality per 1000 person-year among TB and resistant TB cases and to identifying factors associated with mortality. METHODS:This is a retrospective cohort study of...
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pub_type: 杂志文章
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更新日期:2019-05-16 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-7
更新日期:2007-02-22 00:00:00
abstract:BACKGROUND:Pneumocystis pneumonia (PCP) may develop as a clinical manifestation of nosocomial pneumonia by means of either reactivation of resident P. jirovecii or de novo infection. However, there have been no studies describing the clinical characteristics of hospital-onset PCP. METHODS:A retrospective review of med...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0847-6
更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Prenatal exposure to influenza or fever is associated with risk of congenital malformations. Oseltamivir is used to treat influenza and to provide post-exposure prophylaxis. We examined the association between oseltamivir use during pregnancy and birth outcomes. METHODS:This was a nationwide registry-based ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3423-z
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, which is consistent w...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3348-6
更新日期:2018-08-24 00:00:00
abstract:BACKGROUND:Consumption of unwashed, raw or unhygienically prepared fruits and vegetables act as potential source for the spread of various parasitic diseases. Moreover, the level of contamination and species of contaminant parasites vary from place to place because of variations in environmental and human factors. Ther...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4020-5
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Due to a lack of survey of health care seeking behavior for influenza, the actual magnitude of influenza in Beijing of China has not been well described. METHODS:During 2013-2014 influenza season, two cross-sectional household surveys were carried out respectively during the epidemic and non-epidemic season...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2217-z
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:The most optimal antifungal agent for empiric treatment of invasive fungal diseases (IFDs) in febrile neutropenia is controversial. Our objective was evaluate the relative efficacy of antifungals for all-cause mortality, fungal infection-related mortality and treatment response in this population. METHODS:P...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-017-2263-6
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Many people have multiple infections at the same time, but the combined contribution of those infections to disease-related mortality is unknown. Registered causes of death offer a unique opportunity to study associations between multiple infections. METHODS:We analysed over 900,000 death certificates that ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1118-2
更新日期:2015-10-06 00:00:00