Abstract:
BACKGROUND:Many people have multiple infections at the same time, but the combined contribution of those infections to disease-related mortality is unknown. Registered causes of death offer a unique opportunity to study associations between multiple infections. METHODS:We analysed over 900,000 death certificates that reported infectious causes of death. We tested whether reports of multiple infections (i.e., co-infections) differed across individuals' age or sex. We also tested whether each pair of infections were reported together more or less often than expected by chance, and whether this co-reporting was associated with the number of biological characteristics they had in common. RESULTS:In England and Wales, and the USA, 10 and 6 % respectively of infection-related deaths involved co-infection. Co-infection was reported reported most often in young adults; 30 % of infection-related deaths among those aged 25-44 from the USA, and 20 % of infection-related deaths among those aged 30-39 from England and Wales, reported multiple infections. The proportion of infection-related deaths involving co-infection declined with age more slowly in males than females, to less than 10 % among those aged >65. Most associated pairs of infections co-occurred more often than expected from their frequency of being reported alone (488/683 [71 %] in the USA, 129/233 [55 %] in England and Wales), and tended to share biological characteristics (taxonomy, transmission mode, tropism or timescale). CONCLUSIONS:Age, sex, and biologically similar infections are associated with death from co-infection, and may help indicate patients at risk of severe co-infection.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Griffiths EC,Pedersen AB,Fenton A,Petchey OLdoi
10.1186/s12879-015-1118-2subject
Has Abstractpub_date
2015-10-06 00:00:00pages
411issn
1471-2334pii
10.1186/s12879-015-1118-2journal_volume
15pub_type
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2012-12-13 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-06-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-11-02 00:00:00
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更新日期:2017-10-02 00:00:00
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pub_type: 杂志文章,多中心研究
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