Abstract：
BACKGROUND:Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acyclovir are currently used in anti-HSV therapies; however, clinical overuse of these drugs has led to the emergence of drug-resistant viral strains. Hence, there is an urgent need to develop new anti-HSV agents. METHODS:To identify novel anti-HSV-1 compounds, we screened the LOPAC small scale library of 1280 bioactive compounds to identify inhibitors of HSV-1-induced necroptosis. Further experiments including western blot analysis, Q-PCR analysis and immunohistochemistry were performed to explore the antiviral mechanism of the compounds. RESULTS:Here, we identified PHA767491 as a new inhibitor of HSV. PHA767491 potently blocked the proliferation of HSV in cells, as well as HSV induced cell death. Further, we found that PHA767491 strongly inhibited HSV infection post viral entry. Moreover, PHA767491 reduced the expression of viral genes required for DNA synthesis including UL30/42 DNA polymerase and UL5/8/52 helicase-primase complex. The essential immediate early (IE) genes such as ICP4 and ICP27 are critical for the expression of the early and late genes. Of note, PHA767491 inhibited the expression of all IE genes of both HSV-1 and HSV-2. Importantly, PHA767491 reduced viral titers in the tissues from the mice infected with HSV-1. Consistently, immunohistochemistry analysis showed that PHA767491 dramatically attenuated expression of viral protein gB in the livers. CONCLUSIONS:Taken together, PHA767491 has potent anti-HSV activity by inhibiting viral replication both in vitro and in mouse model. Thus, PHA767491 could be a promising agent for the development of new anti-HSV therapy.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hou J,Zhang Z,Huang Q,Yan J,Zhang X,Yu X,Tan G,Zheng C,Xu F,He Sdoi
10.1186/s12879-017-2305-0subject
Has Abstractpub_date
2017-03-20 00:00:00pages
217issue
1issn
1471-2334pii
10.1186/s12879-017-2305-0journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Estimates of Human Papillomavirus (HPV) prevalence in a population prior to and after HPV vaccine introduction are essential to evaluate the short-term impact of vaccination. METHODS:Between 2010 and 2012 we conducted a population-based cross-sectional study in Germany to determine HPV prevalence, genotype ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-87
更新日期：2014-02-19 00:00:00
abstract：BACKGROUND:Enterovirus 71 (EV-A71) shows a potential of rapid death, but the natural history of the infection is poorly known. This study aimed to examine the natural history of EV-A71 infection. METHODS:This was a prospective longitudinal observational study performed between January 1st and October 31st, 2012, at th...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/s12879-017-2228-9
更新日期：2017-02-17 00:00:00
abstract：BACKGROUND:Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2667-3
更新日期：2017-08-11 00:00:00
abstract：BACKGROUND:Globally, diarrhea is the leading cause of morbidity and mortality among less than 5 years old children and it contributes to the deaths of approximately one million children every year. In Ethiopia, diarrhea is the second cause of under-five mortality and morbidity. However, in the study area, studies were ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4445-x
更新日期：2019-09-13 00:00:00
abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen resistance to antibiotics including methicillin. The resistance first emerged in 1960 in a healthcare setting only after two years of using methicillin as a viable treatment for methicillin-susceptible Staphylococcus aureus. MRSA lead...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-2973-4
更新日期：2018-02-07 00:00:00
abstract：BACKGROUND:The role of Diabetes mellitus (DM) in the etiology and in the antimicrobial resistance of uropathogens in patients with urinary tract infection has not been well clarified. For this reason we have evaluated the spectrum of uropathogens and the profile of antibiotic resistance in both diabetic and non diabeti...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-6-54
更新日期：2006-03-17 00:00:00
abstract：BACKGROUND:It is unclear whether appropriate empiric antimicrobial therapy improves outcomes in patients with bacteremia due to Escherichia coli or Klebsiella. The objective of this study is to assess the impact of appropriate empiric antimicrobial therapy on in-hospital mortality and post-infection length of stay in p...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-8-116
更新日期：2008-09-15 00:00:00
abstract：BACKGROUND:Understanding the underlying epidemiology that shapes Neisseria gonorrhoeae (GC), and Chlamydia trachomatis (CT) infections can contribute to data driven policies directed towards curbing the proliferation of these pathogens in Ghana. Information on the symptoms and risk factors for STIs will help to identif...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4035-y
更新日期：2019-05-16 00:00:00
abstract：BACKGROUND:Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS:We studied patients with...
journal_title：BMC infectious diseases
pub_type： 临床试验,杂志文章
doi：10.1186/s12879-016-1896-1
更新日期：2016-10-10 00:00:00
abstract：BACKGROUND:Middle East Respiratory Syndrome (MERS) is caused by MERS coronavirus (MERS-CoV). More than 80% of reported cases have occurred in Saudi Arabia, with a mortality exceeding 50%. Health-care workers (HCWs) are at risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding M...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-2096-8
更新日期：2017-01-03 00:00:00
abstract：BACKGROUND:Although a dramatic decrease in AIDS progression has been observed after Highly Active Anti Retroviral Therapy (HAART) in both low- and high-resource settings, few data support that fact in low-resource settings.This study describes the incidence of AIDS-defining illnesses (ADI) after HAART initiation and an...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-10-179
更新日期：2010-06-19 00:00:00
abstract：BACKGROUND:HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density. METHODS:We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucle...
journal_title：BMC infectious diseases
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2334-13-293
更新日期：2013-06-28 00:00:00
abstract：BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-4775-8
更新日期：2020-01-13 00:00:00
abstract：BACKGROUND:Klebsiella pneumoniae bloodstream infections (BSIs) occur with significant prevalence and high mortality worldwide. Antimicrobial resistance and virulence are two main factors participating in the pathogenicity of K. pneumoniae. Here we investigated the prevalence of blaKPC and virulence factors in K. pneumo...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3263-x
更新日期：2018-07-31 00:00:00
abstract：BACKGROUND:Statin use is associated with a modest increase in the incidence of type 2 diabetes mellitus (DM) among the general population. However, HIV-infected patients have a higher risk of developing DM, and it is unclear whether statins have a diabetogenic effect in these patients. Therefore, we investigated the as...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-2099-5
更新日期：2017-01-07 00:00:00
abstract：BACKGROUND:There is paucity of data on seasonal variation in pulmonary tuberculosis (TB) in developing countries contrary to recognized seasonality in the TB notification in western societies. This study examined the seasonal pattern in TB diagnosis among migrant workers from developing countries entering Kuwait. METH...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-8-3
更新日期：2008-01-07 00:00:00
abstract：BACKGROUND:Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, ga...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/s12879-018-3232-4
更新日期：2018-07-11 00:00:00
abstract：BACKGROUND:Mucormycosis is a rare but devastating fungal infection primarily affecting immunocompromised patients such as those with hematological malignancy, bone marrow and solid organ transplantation, and patients with diabetes, and, even more rarely, immunocompetent patients. The objective of this study was to asse...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-2023-z
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Necrotizing fasciitis (NF) is a rapidly progressive and life-threatening infection. This study aimed to investigate the clinical characteristics and mortality- associated factors in diabetic patients. METHODS:Detailed clinical information of 165 NF cases was retrospectively collected and analyzed in Nationa...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1144-0
更新日期：2015-10-13 00:00:00
abstract：BACKGROUND:The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information on XDR TB is available. Hence, the eval...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3009-9
更新日期：2018-02-27 00:00:00
abstract：BACKGROUND:HIV-associated neurocognitive disorder (HAND) remains prevalent in the era of combination antiretroviral therapy (cART). The prevalence of HAND in Hong Kong is not known. METHODS:Between 2013 and 2015, 98 treatment-naïve HIV-1-infected individuals were referred to and screened by the AIDS Clinical Service, ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-3784-y
更新日期：2019-02-13 00:00:00
abstract：BACKGROUND:Increasing the dosage of daptomycin may be advantageous in severe infection by enhancing bactericidal activity and pharmacodynamics. However, clinical data on using daptomycin at doses above 6 mg/kg in Asian population are limited. METHODS:A retrospective observational cohort study of all hospitalized adult...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-66
更新日期：2013-02-04 00:00:00
abstract：BACKGROUND:Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging....
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1475-5
更新日期：2016-04-12 00:00:00
abstract：BACKGROUND:Staphylococcus aureus strains are now regarded as zoonotic agents. In pastoral settings where human-animal interaction is intimate, multi-drug resistant microorganisms have become an emerging zoonotic issue of public health concern. The study of S. aureus prevalence, antimicrobial resistance and clonal linea...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2524-4
更新日期：2017-06-13 00:00:00
abstract：BACKGROUND:Early insights into the timing of the start, peak, and intensity of the influenza season could be useful in planning influenza prevention and control activities. To encourage development and innovation in influenza forecasting, the Centers for Disease Control and Prevention (CDC) organized a challenge to pre...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1669-x
更新日期：2016-07-22 00:00:00
abstract：BACKGROUND:Klebsiella pneumoniae is a frequent nosocomial pathogen causing difficult-to-treat infections worldwide. The prevalence of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-KP) is increasing in China. The aim of this study was to investigate the molecular epidemiology of KPC-KP i...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2467-9
更新日期：2017-05-23 00:00:00
abstract：BACKGROUND:Helicobacter cinaedi is a rare pathogen in humans, occurring mostly in immuno-compromised patients, with a high potential for recurrence. We describe a case of a patient with lymphoma hospitalized for chemotherapy. CASE PRESENTATION:At admission, the patient presented with an indolent and non-prurigenic mac...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/1471-2334-6-86
更新日期：2006-05-23 00:00:00
abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative bacteria responsible for infections in immunocompromised patients and is one of the most common causes of nosocomial infections particularly in intensive care and burn units. We aimed to investigate the population structure of P. aeruginosa strains isolated from pati...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/s12879-020-05404-w
更新日期：2020-09-22 00:00:00
abstract：BACKGROUND:For approximately 24 years the AIDS pandemic has claimed approximately 30 million lives, causing approximately 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmissio...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-4-41
更新日期：2004-10-14 00:00:00
abstract：BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1285-1
更新日期：2015-12-03 00:00:00
