当前位置： SCI文献检索 > BMC INFECTIOUS DISEASES期刊下所有文献 > Incidence and determinants of new AIDS-defining illnesses after HAART initiation in a Senegalese cohort.

Incidence and determinants of new AIDS-defining illnesses after HAART initiation in a Senegalese cohort.

Abstract：

BACKGROUND:Although a dramatic decrease in AIDS progression has been observed after Highly Active Anti Retroviral Therapy (HAART) in both low- and high-resource settings, few data support that fact in low-resource settings.This study describes the incidence of AIDS-defining illnesses (ADI) after HAART initiation and analyzes their risk factors in a low-resource setting. A focus was put on CD4 cell counts and viral load measurements. METHODS:404 HIV-1-infected Senegalese adult patients were enrolled in a prospective observational cohort and data censored as of April 2008. A Poisson regression was used to model the incidence of ADIs over two periods and to assess its association with baseline variables, current CD4, current viral load, CD4 response, and virological response. RESULTS:ADI incidence declined from 20.5 ADIs per 100 person-years, 95% CI = [16.3;25.8] during the first year to 4.3, 95% CI = [2.3;8.1] during the fourth year but increased afterwards. Before 42 months, the decrease was greater in patients with clinical stage CDC-C at baseline and with a viral load remaining below 1000 cp/mL but was uniform across CD4 strata (p = 0.1). After 42 months, 293 patients were still at risk. The current CD4 and viral load were associated with ADI incidence (decrease of 21% per 50 CD4/mm3 and of 61% for patients with a viral load < 1000 cp/mL). CONCLUSIONS:During the first four years, a uniform decline of ADI incidence was observed even in patients with low CD4-cell counts at HAART initiation as long as the viral load remained undetectable. An increase was noted later in patients with immunologic and virological failures but also in patients with only virological failure.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

De Beaudrap P,Etard JF,Diouf A,Ndiaye I,Ndèye GF,Sow PS,Ndèye KC,Ecochard R,Delaporte E,ANRS 1215 Study Group.

doi

10.1186/1471-2334-10-179

subject

Has Abstract

pub_date

2010-06-19 00:00:00

pages

179

issn

1471-2334

pii

1471-2334-10-179

journal_volume

10

pub_type

杂志文章

相关文献

BMC INFECTIOUS DISEASES文献大全
  • Emergence and spread of a new community-genotype methicillin-resistant Staphylococcus aureus clone in Colombia.

    abstract：BACKGROUND:Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) clones are a global concern due to their resistance and increased virulence and their ability to cause infections both hospitalized patients and healthy people in the community. Here, we characterize 32 isolates of a new CG-MRSA clone. ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-017-2193-3

    authors： Escobar-Perez J,Reyes N,Marquez-Ortiz RA,Rebollo J,Pinzón H,Tovar C,Moreno-Castañeda J,Corredor ZL,Castro BE,Moncada MV,Vanegas N

    更新日期：2017-01-31 00:00:00

  • A multicenter randomized placebo controlled trial of rifampin to reduce pedal amputations for osteomyelitis in veterans with diabetes (VA INTREPID).

    abstract：BACKGROUND:The prevalence of diabetes mellitus continues to inexorably rise in the United States and throughout the world. Lower limb amputations are a devastating comorbid complication of diabetes mellitus. Osteomyelitis increases the risk of amputation fourfold and commonly presages death. Antimicrobial therapy for d...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12879-019-4751-3

    authors： Bessesen MT,Doros G,Henrie AM,Harrington KM,Hermos JA,Bonomo RA,Ferguson RE,Huang GD,Brown ST

    更新日期：2020-01-08 00:00:00

  • Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials.

    abstract：BACKGROUND:Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity between GlaxoSmithKline Vaccines' A/California/7/2009 (H1N1)v-like-AS03 vaccines manufactured in Dresden ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2334-13-435

    authors： Launay O,Duval X,Fitoussi S,Jilg W,Kerdpanich A,Montellano M,Schwarz TF,Watanveerade V,Wenzel JJ,Zalcman G,Bambure V,Li P,Caplanusi A,Madan A,Gillard P,Vaughn DW

    更新日期：2013-09-16 00:00:00

  • Increased physiological dead space in mechanically ventilated COVID-19 patients recovering from severe acute respiratory distress syndrome: a case report.

    abstract：BACKGROUND:An ongoing outbreak of coronavirus disease 2019 (COVID-19) is spreading globally. Recently, several articles have mentioned that the early acute respiratory distress syndrome (ARDS) caused by COVID-19 significantly differ from those of ARDS due to other causes. Actually, we newly observed that some mechanica...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-020-05360-5

    authors： Xia J,Feng Y,Li M,Yu X,Zhang Y,Duan J,Zhan Q

    更新日期：2020-08-27 00:00:00

  • Mitigating effects of vaccination on influenza outbreaks given constraints in stockpile size and daily administration capacity.

    abstract：BACKGROUND:Influenza viruses are a major cause of morbidity and mortality worldwide. Vaccination remains a powerful tool for preventing or mitigating influenza outbreaks. Yet, vaccine supplies and daily administration capacities are limited, even in developed countries. Understanding how such constraints can alter the ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-11-207

    authors： Cruz-Aponte M,McKiernan EC,Herrera-Valdez MA

    更新日期：2011-08-01 00:00:00

  • Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010.

    abstract：BACKGROUND:Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbo...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-017-2840-8

    authors： Gadia CLB,Manirakiza A,Tekpa G,Konamna X,Vickos U,Nakoune E

    更新日期：2017-11-29 00:00:00

  • Traditional and HIV-specific risk factors for cardiovascular morbidity and mortality among HIV-infected adults in Brazil: a retrospective cohort study.

    abstract：BACKGROUND:Antiretroviral therapy (ART) agents potentially associated with adverse metabolic profiles are commonly used in low- and middle-income countries. We assessed risk factors for cardiovascular disease (CVD)-related morbidity and mortality in a cohort of HIV-infected, ART-treated adults in Rio de Janeiro, Brazil...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1735-4

    authors： Diaz CM,Segura ER,Luz PM,Clark JL,Ribeiro SR,De Boni R,Eksterman L,Moreira R,Currier JS,Veloso VG,Grinsztejn B,Lake JE

    更新日期：2016-08-08 00:00:00

  • Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report.

    abstract：BACKGROUND:Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both a...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-14-330

    authors： Schoffelen T,den Broeder AA,Nabuurs-Franssen M,van Deuren M,Sprong T

    更新日期：2014-06-15 00:00:00

  • Twelve years' detection of respiratory viruses by immunofluorescence in hospitalised children: impact of the introduction of a new respiratory picornavirus assay.

    abstract：BACKGROUND:Direct immunofluorescence assays (DFA) are a rapid and inexpensive method for the detection of respiratory viruses and may therefore be used for surveillance. Few epidemiological studies have been published based solely on DFA and none included respiratory picornaviruses and human metapneumovirus (hMPV). We ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-11-41

    authors： Sadeghi CD,Aebi C,Gorgievski-Hrisoho M,Mühlemann K,Barbani MT

    更新日期：2011-02-07 00:00:00

  • Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools.

    abstract：BACKGROUND:Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control strategy, particularly in schools where viral transm...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-13-71

    authors： Koep TH,Enders FT,Pierret C,Ekker SC,Krageschmidt D,Neff KL,Lipsitch M,Shaman J,Huskins WC

    更新日期：2013-02-05 00:00:00

  • An assessment of the level of concern among hospital-based health-care workers regarding MERS outbreaks in Saudi Arabia.

    abstract：BACKGROUND:Middle East Respiratory Syndrome (MERS) is caused by MERS coronavirus (MERS-CoV). More than 80% of reported cases have occurred in Saudi Arabia, with a mortality exceeding 50%. Health-care workers (HCWs) are at risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding M...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-2096-8

    authors： Abolfotouh MA,AlQarni AA,Al-Ghamdi SM,Salam M,Al-Assiri MH,Balkhy HH

    更新日期：2017-01-03 00:00:00

  • Multi-complexity measures of heart rate variability and the effect of vasopressor titration: a prospective cohort study of patients with septic shock.

    abstract：BACKGROUND:Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS:We studied patients with...

    journal_title：BMC infectious diseases

    pub_type： 临床试验,杂志文章

    doi：10.1186/s12879-016-1896-1

    authors： Brown SM,Sorensen J,Lanspa MJ,Rondina MT,Grissom CK,Shahul S,Mathews VJ

    更新日期：2016-10-10 00:00:00

  • Decreasing trends, and geographical variation in outpatient antibiotic use: a population-based study in Central Denmark.

    abstract：BACKGROUND:Antimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority. METHODS:We examined recent time trends in the utilization of narrow- and broad-spectrum antibio...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-019-3964-9

    authors： Kristensen PK,Johnsen SP,Thomsen RW

    更新日期：2019-04-24 00:00:00

  • High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo.

    abstract：BACKGROUND:Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub-Saharan Africa. The Efé pygmies living in Democratic Republic of the Congo are known to be ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1607-y

    authors： Mulangu S,Borchert M,Paweska J,Tshomba A,Afounde A,Kulidri A,Swanepoel R,Muyembe-Tamfum JJ,Van der Stuyft P

    更新日期：2016-06-10 00:00:00

  • A case report of HIV-1 superinfection in an HIV controller leading to loss of viremia control: a retrospective of 10 years of follow-up.

    abstract：BACKGROUND:HIV controllers (HICs) are a rare group of HIV-1-infected individuals able to naturally control viral replication. Several studies have identified the occurrence of HIV dual infections in seropositive individuals leading to disease progression. In HICs, however, dual infections with divergent outcomes in pat...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-019-4229-3

    authors： Caetano DG,Côrtes FH,Bello G,de Azevedo SSD,Hoagland B,Villela LM,Grinsztejn B,Veloso VG,Guimarães ML,Morgado MG

    更新日期：2019-07-05 00:00:00

  • Brucella abortus: determination of survival times and evaluation of methods for detection in several matrices.

    abstract：BACKGROUND:Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used as a first step in diagnostics to increase the bacterial number above the detection limit of the ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-018-3134-5

    authors： Kaden R,Ferrari S,Jinnerot T,Lindberg M,Wahab T,Lavander M

    更新日期：2018-06-05 00:00:00

  • Prevalence of Chlamydia trachomatis infection in women, heterosexual men and MSM visiting HIV counselling institutions in North Rhine-Westphalia, Germany - should Chlamydia testing be scaled up?

    abstract：BACKGROUND:Patients asking for a free anonymous HIV test may have contracted other sexually transmitted infections (STIs) such as Chlamydia trachomatis, yet Chlamydia prevalence in that population is unknown. This study aimed to assess the prevalence and factors associated with Chlamydia infection in patients seeking H...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1915-2

    authors： Lallemand A,Bremer V,Jansen K,Nielsen S,Münstermann D,Lucht A,Tiemann C

    更新日期：2016-10-26 00:00:00

  • Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China.

    abstract：BACKGROUND:Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS:The medical and electronic records of all patie...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-13-337

    authors： Ma CF,Li FQ,Shi LN,Hu YA,Wang Y,Huang M,Kong QQ

    更新日期：2013-07-22 00:00:00

  • Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

    abstract：BACKGROUND:After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the dev...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-019-3690-3

    authors： Zhang JW,Zhang XZ,Sun YL,Long B,Wang XZ,Li XD

    更新日期：2019-01-16 00:00:00

  • Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice.

    abstract：BACKGROUND:Toxoplasmosis is a worldwide zoonosis caused by the intracellular parasite Toxoplasma gondii. However, no effective vaccine is yet available. Poly(lactide-co-glycolide) polymers can reduce protein degradation and sustain the release of antigens over a long period, which could generate a long-lasting immune r...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1496-0

    authors： Zhang NZ,Xu Y,Wang M,Chen J,Huang SY,Gao Q,Zhu XQ

    更新日期：2016-04-18 00:00:00

  • The spatiotemporal distribution of human brucellosis in mainland China from 2007-2016.

    abstract：BACKGROUND:Despite the considerable efforts made to address the issue of brucellosis worldwide, its prevalence in dairy products continues to be difficult to estimate and represents a key public health issue around the world today. The aim of the present study was to better understand the epidemiology of this disease i...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-020-4946-7

    authors： Liang P,Zhao Y,Zhao J,Pan D,Guo Z

    更新日期：2020-03-27 00:00:00

  • Tuberculosis infection control knowledge and attitudes among health workers in Uganda: a cross-sectional study.

    abstract：BACKGROUND:The World Health Organization recommends TB infection control (TBIC) in health care facilities. In 2008, the Ministry of Health Uganda initiated efforts to implement TBIC by training of health care workers (HCWs). This study was carried out to assess knowledge and attitudes towards TBIC among HCWs. METHODS:...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1740-7

    authors： Buregyeya E,Kasasa S,Mitchell EM

    更新日期：2016-08-15 00:00:00

  • Interleukin-28B gene non-TT allele strongly predicts treatment failure for genotype 1 infected chronic hepatitis C patients with advanced fibrosis: a case control study.

    abstract：BACKGROUND:The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predi...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-0888-x

    authors： Hu CC,Lin CL,Chang LC,Chien CH,Chen LW,Liu CJ,Chien RN

    更新日期：2015-03-26 00:00:00

  • Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.

    abstract：BACKGROUND:The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. METHODS:We performed a prospective multicentre study in inmates from 25 Spanis...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12879-015-1102-x

    authors： Marco A,Antón JJ,Trujols J,Saíz de la Hoya P,de Juan J,Faraco I,Caylà JA,Perseo Group.

    更新日期：2015-08-19 00:00:00

  • Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: an observational study.

    abstract：BACKGROUND:Leptospirosis has a varied clinical presentation with complications like myocarditis and acute renal failure. There are many predictors of severity and mortality including clinical and laboratory parameters. Early detection and treatment can reduce complications. Therefore recognizing the early predictors of...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-12-4

    authors： Dassanayake DL,Wimalaratna H,Nandadewa D,Nugaliyadda A,Ratnatunga CN,Agampodi SB

    更新日期：2012-01-13 00:00:00

  • Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature.

    abstract：BACKGROUND:Helicobacter cinaedi is a rare pathogen in humans, occurring mostly in immuno-compromised patients, with a high potential for recurrence. We describe a case of a patient with lymphoma hospitalized for chemotherapy. CASE PRESENTATION:At admission, the patient presented with an indolent and non-prurigenic mac...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2334-6-86

    authors： Uçkay I,Garbino J,Dietrich PY,Ninet B,Rohner P,Jacomo V

    更新日期：2006-05-23 00:00:00

  • Parental attitudes towards measles vaccination in the canton of Aargau, Switzerland: a latent class analysis.

    abstract：BACKGROUND:Despite the successes of routine national childhood vaccination programmes, measles remains a public health concern. The purpose of this paper is to investigate how patterns of parental attitudes are linked to the decision-making process for or against MMR vaccination. This exploratory study was designed to ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1747-0

    authors： Weiss C,Schröpfer D,Merten S

    更新日期：2016-08-11 00:00:00

  • Antimicrobial resistance of Neisseria gonorrhoeae in Germany: low levels of cephalosporin resistance, but high azithromycin resistance.

    abstract：BACKGROUND:The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because N. gonorrhoeae infections are not reportable in Germany, only limited data on disease epidemiolo...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-018-2944-9

    authors： Buder S,Dudareva S,Jansen K,Loenenbach A,Nikisins S,Sailer A,Guhl E,Kohl PK,Bremer V,GORENET study group.

    更新日期：2018-01-17 00:00:00

  • Acinetobacter calcoaceticus from a fatal case of pneumonia harboring bla(NDM-1) on a widely distributed plasmid.

    abstract：BACKGROUND:We have recovered one bla(NDM-1)-harboring bacterial strain, designated as XM1570, from a sputum sample obtained from a fatal case of pneumonia in China. METHODS:Biochemical profiling, 16S rRNA sequencing and antimicrobial susceptibility testing were performed. Conjugation experiments were conducted to dete...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-0870-7

    authors： Li P,Yang C,Xie J,Liu N,Wang H,Zhang L,Wang X,Wang Y,Qiu S,Song H

    更新日期：2015-03-18 00:00:00

  • Factors associated with unreported tuberculosis cases in Spanish hospitals.

    abstract：BACKGROUND:Under-reporting of tuberculosis (TB) cases complicates disease control, hinders contact tracing and alters the accuracy of epidemiological data, including disease burden. The objective of the present study is to evaluate the proportion of unreported TB cases in Spanish healthcare facilities and to identify t...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-1047-0

    authors： Morales-García C,Rodrigo T,García-Clemente MM,Muñoz A,Bermúdez P,Casas F,Somoza M,Milá C,Penas A,Hidalgo C,Casals M,Caylá JA,Working Group on Under-reporting of Tuberculosis in Spain.

    更新日期：2015-07-29 00:00:00