Abstract:
BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from autopsy series. CASE PRESENTATION:We report the case of a 17 year old immunocompetent girl who presented with history of fever, malaise, foot gangrene and a left sided hemiparesis. On investigation she was found to have infective endocarditis involving the aortic, mitral and tricuspid valves. She had developed a right middle cerebral artery stroke. She underwent dual valve replacement and tricuspid repair. The vegetations showed granulomatous inflammation but blood cultures and other biological specimen cultures were negative for any organisms. She was started on antituberculous treatment and anticoagulation. CONCLUSION:This is the first reported case of triple valve endocarditis by Mycobacterium Tuberculosis in an immunocompetent host. Especially important is the fact that the right heart is involved which has been historically described in the setting of intravenous drug abuse.This implies that Tuberculosis should be considered in cases of culture negative endocarditis in endemic areas like Pakistan even in immunocompetent hosts.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Shaikh Q,Mahmood Fdoi
10.1186/1471-2334-12-231subject
Has Abstractpub_date
2012-09-27 00:00:00pages
231issn
1471-2334pii
1471-2334-12-231journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycobacterium tuberculosis (MTB) has been investigated in many regions, there have been only a few stu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3351-y
更新日期:2018-09-03 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
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更新日期:2021-01-04 00:00:00
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更新日期:2016-12-08 00:00:00
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更新日期:2016-10-28 00:00:00
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更新日期:2017-08-08 00:00:00
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更新日期:2012-06-07 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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abstract:BACKGROUND:Haemorrhagic fever with renal syndrome (HFRS) is a natural epidemic disease caused by various types of viruses of the genus Hantavirus, which are mainly transmitted by contact with the infected rodents and their droppings. Pregnancy complicated with HFRS is rare; however, adverse maternal and foetal outcomes...
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