Abstract:
BACKGROUND:To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS:From September 2014 to November 2015, HIV-infected patients seeking outpatient care at four hospitals were eligible for this study. A nasal specimen was obtained from each subject for the detection of S. aureus and a questionnaire was completed by each subject. MRSA isolates once identified were characterized. RESULTS:Of 553 patients surveyed, methicillin-susceptible S. aureus (MSSA) was detected in 119 subjects (21.5%) and MRSA in 19 subjects (3.4%). Female gender, injection drug use, smoking, hepatitis C virus carrier, cancer and antibiotic use within 1 year were positively associated with MRSA colonization. By multivariate analysis, only cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909-31.731]) and antibiotic use within 1 year (aOR 3.89, [95% CI, 1.219-12.433]) were significantly associated with MRSA colonization. Ten isolates were characterized as sequence type (ST) 59/staphylococcal chromosome cassette (SCC) IV or VT, endemic community strains in Taiwan, four isolates as ST 8/SCCmec IV (USA 300) and one isolate as ST 239/SCCmec IIIA, a hospital strain. All the community-associated MRSA isolates were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). CONCLUSIONS:Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic community strains and exhibited high susceptibility to TMP-SMX and fluoroquinolones. Cancer and antibiotic use within 1 year were associated with MRSA colonization.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hsu YY,Wu D,Hung CC,Huang SS,Yuan FH,Lee MH,Huang CT,Shie SS,Huang PY,Yang CC,Cheng CW,Leu HS,Wu TS,Huang YCdoi
10.1186/s12879-020-04979-8subject
Has Abstractpub_date
2020-03-30 00:00:00pages
254issue
1issn
1471-2334pii
10.1186/s12879-020-04979-8journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Emergence of rmtB-positive Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) poses a great threat to antimicrobial treatment options. METHODS:From January 2010 to December 2010, non-duplicate KPC-KP isolates from our hospital were screened for rmtB and multiple other resistance dete...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-373
更新日期:2012-12-23 00:00:00
abstract:BACKGROUND:Involvement of trochlear nerve during Varicella Zoster Virus (VZV) Infection has been rarely described, and always in association with skin rash. CASE PRESENTATION:We describe the case of a patient with VZV infection presenting as isolated diplopia due to fourth cranial nerve palsy. The diagnosis has been o...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-138
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve this goal. In this study, we aimed to explain this method with the example of Mycobacterium tubercul...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3417-x
更新日期:2018-10-12 00:00:00
abstract:BACKGROUND:At the end of the 1970s, in Italy more than 2% of the general population was HBsAg carrier. In the late '70s and late '80s, two remarkable events might have impacted on HBV strains transmitted in North-East Italy: (a) the increased HBV incidence due to parenteral drugs between 1978 and 1982; (b) the preventi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4713-9
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format. Therefore, this technique has gained recognition as the new international gold standard in typing of Mycobacte...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-63
更新日期:2013-02-02 00:00:00
abstract:BACKGROUND:Over the past several years, new diagnostic techniques have been developed to allow for the rapid detection of multidrug resistant tuberculosis. The GenoType MTBDRplus test is a deoxyribonucleic acid (DNA) strip assay which uses polymerase chain reaction (PCR) and hybridization to detect genetic mutations in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-123
更新日期:2010-05-20 00:00:00
abstract:BACKGROUND:Syndromic management of STIs has been advocated as simplified and cheap approach. Youth have been reported to be at increased risk of acquiring STIs which can facilitate HIV transmission. We have investigated the relationship between the syndromic management and specific aetiology diagnosis and its relations...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-22
更新日期:2006-02-10 00:00:00
abstract:BACKGROUND:Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens. The aim of this study was to investigate the prevalence and molecular characterization of PZA resistance among MDR-TB isolates collected in Chongqing municipality. M...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2761-6
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:The inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates the need for acquirement of reliable and standard diagnostic reagents. Recently, epitope-based antigens have emerged as an alternative diagnostic marker for the achievemen...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2920-9
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:The inflammasome responses in Treponema pallidum infection have been poorly understood to date. This study aimed to investigate the expression of the nucleotide-binding leucine-rich receptor protein 3 (NLRP3) inflammasome in the development of tissue inflammation in rabbits infected with T. pallidum. METHOD...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-2993-0
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease. Dromedary camels have been implicated due to reports that some confirmed cases were exposed to camels. Risk factors for MERS coronavirus (MERS-CoV) infections in humans are incompletely understood. This study aimed to describe ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2137-3
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Efficient control and management in the ongoing COVID-19 pandemic needs to carefully balance economical and realizable interventions. Simulation models can play a cardinal role in forecasting possible scenarios to sustain decision support. METHODS:We present a sophisticated extension of a classical SEIR mod...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05566-7
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mort...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-020-4879-1
更新日期:2020-03-04 00:00:00
abstract::Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can be achieved at the point-of-care within just 30 minutes using the Determine TB-LAM, which is a commercially ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-407
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Rapid influenza diagnosis is important for early identification of outbreaks, effective management of high-risk contacts, appropriate antiviral use, decreased inappropriate antibiotic use and avoidance of unnecessary laboratory testing. Given the inconsistent performance of many rapid influenza tests, clinic...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-129
更新日期:2012-06-07 00:00:00
abstract:BACKGROUND:Dose-response assessment is one step in quantitative microbial risk assessment (QMRA). Four infectious microbes capable of causing respiratory diseases important to public health, and for which dose-response functions have not been available are: Bordetella pertussis (whooping cough), group A Streptococcus (...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0832-0
更新日期:2015-02-24 00:00:00
abstract:BACKGROUND:Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected are unaware of their disease limiting prevention and early treatment options. The purpose of this co...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0854-7
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS:The medical and electronic records of all patie...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-337
更新日期:2013-07-22 00:00:00
abstract:BACKGROUND:Dengue is a major public health problem in tropical and subtropical countries. Rapid and easy diagnosis of dengue can assist patient triage and care-management. The detection of DENV NS1 on rapid lateral flow tests offers a fast route to a presumptive dengue diagnosis but careful evaluations are urgently nee...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-142
更新日期:2010-05-28 00:00:00
abstract:BACKGROUND:To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). METHODS:Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disor...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-102
更新日期:2005-11-08 00:00:00
abstract:BACKGROUND:We sought to assess reporting in China's Pneumonia of Unknown Etiology (PUE) passive surveillance system for emerging respiratory infections and to identify ways to improve the PUE surveillance system's detection of respiratory infections of public health significance. METHODS:From February 29-May 29, 2016,...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4345-0
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide, and increasing rates of fluoroquinolone (FQ) resistance in C. jejuni are a major public health concern. The rapid detection and tracking of FQ resistance are critical needs in developing countries, as these antimicrobials are widely use...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05202-4
更新日期:2020-07-16 00:00:00
abstract:BACKGROUND:Lyme disease, a bacterial infection with the tick-borne spirochete Borrelia burgdorferi, can cause early and late manifestations. The category of probable Lyme disease was recently added to the CDC surveillance case definition to describe patients with serologic evidence of exposure and physician-diagnosed d...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-173
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Some children are prone to recurrent invasive pneumococcal disease (rIPD) and of these, some respond insufficiently to standard pneumococcal vaccination. Little is known about how to handle these children and if they benefit from additional vaccination. Here, we present results from a nationwide study of ped...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3267-6
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:The optimal therapeutic strategies for patients presenting with advanced disease at HIV-1 diagnosis are as yet incompletely defined. METHODS:All patients presenting at two outpatient clinics in 2000-2009 with an AIDS-defining clinical condition or a CD4+ T cell count < 200/μL at HIV-1 diagnosis were analyze...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-341
更新日期:2011-12-14 00:00:00
abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-32
更新日期:2008-03-06 00:00:00
abstract:BACKGROUND:Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with inva...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-11-60
更新日期:2011-03-09 00:00:00
abstract:BACKGROUND:Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished to explore temporal trends of OAI caused by Group A Streptococci (GAS), Group B Streptococci (GBS...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1874-7
更新日期:2016-10-04 00:00:00
abstract:BACKGROUND:Extended use of oseltamivir in an immunocompromised host could reportedly induce neuraminidase gene mutation possibly leading to oseltamivir-resistant influenza A/H3N2 virus. To our knowledge, no report is available on the clinical course of a severely immunocompromised patient with a dual E119D/R292K neuram...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05205-1
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:The aim of this study was to characterize the spread of carbapenemase-producing Klebsiella pneumoniae (CPKP) in a tertiary level hospital using ongoing active surveillance with rectal swab cultures. Furthermore, this study analyzed the presence of CPKP in the clinical samples (CS) of a single patient as well...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0996-7
更新日期:2015-06-27 00:00:00