Abstract:
BACKGROUND:The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. METHODS:The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were done every two hours for three consecutive days after hospital admission in 142 patients at high-risk for sepsis by placing the OB on the forefinger. At the second phase, single recordings were done in 54 patients with symptoms of viral infection; 38 were diagnosed with COVID-19. RESULTS:At the first phase, the cutoff value of positive likelihood of 18 provided 100% specificity and 100% positive predictive value for the diagnosis of sepsis. These were 87.5 and 91.7% respectively at the second phase. OB diagnosed severe COVID-19 with 83.3% sensitivity and 87.5% negative predictive value. CONCLUSIONS:The studied OB seems valuable for the discrimination of infection severity.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Doulou S,Leventogiannis K,Tsilika M,Rodencal M,Katrini K,Antonakos N,Kyprianou M,Karofylakis E,Karageorgos A,Koufargyris P,Christopoulos G,Kassianidis G,Stamatelopoulos K,Newberry R,Giamarellos-Bourboulis EJdoi
10.1186/s12879-020-05607-1subject
Has Abstractpub_date
2020-11-19 00:00:00pages
860issue
1issn
1471-2334pii
10.1186/s12879-020-05607-1journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. CASE PRESENTATION:We report the first case of CHIKV infec...
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journal_title:BMC infectious diseases
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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