Abstract:
BACKGROUND:Prenatal exposure to influenza or fever is associated with risk of congenital malformations. Oseltamivir is used to treat influenza and to provide post-exposure prophylaxis. We examined the association between oseltamivir use during pregnancy and birth outcomes. METHODS:This was a nationwide registry-based prevalence study with individual level data linkage, in a setting of universal health care access. We included all recorded pregnancies in Denmark in 2002-2013, and used data from population registries to examine associations between dispensings for oseltamivir during pregnancy (first trimester, second/third trimester, none) and congenital malformations, foetal death, preterm birth, foetal growth, and low 5-min Apgar score. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using propensity score matching. RESULTS:The study included 946,176 pregnancies. Of these, 449 had first-trimester exposure and 1449 had second/third-trimester exposure to oseltamivir. Adjusted ORs following first-trimester exposure were 0.94 (95% CI 0.49 to 1.83) for any major congenital malformation and 1.75 (95% CI 0.51 to 5.98) for congenital heart defects, based on 7 exposed cases. The association with congenital heart defects was present for etiologically implausible exposure periods and for known safe exposures. There was no evidence of an association between prenatal exposure to oseltamivir and any of the other birth outcomes assessed. CONCLUSIONS:The study does not provide evidence of risk associated with oseltamivir treatment additional to that associated with influenza infection.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Ehrenstein V,Kristensen NR,Monz BU,Clinch B,Kenwright A,Sørensen HTdoi
10.1186/s12879-018-3423-zsubject
Has Abstractpub_date
2018-10-16 00:00:00pages
519issue
1issn
1471-2334pii
10.1186/s12879-018-3423-zjournal_volume
18pub_type
杂志文章abstract:BACKGROUND:Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical are...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1704-y
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-330
更新日期:2014-06-15 00:00:00
abstract:BACKGROUND:While several studies have assessed the associations between biological factors and tuberculosis (TB) transmission, our understanding of the associations between TB transmission and social and economic factors remains incomplete. We aimed to explore associations between community TB transmission and socio-ec...
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pub_type: 杂志文章
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更新日期:2020-02-10 00:00:00
abstract:BACKGROUND:Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. METHODS:A cross-sectional study was conducted to evaluate relationships between serum s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-85
更新日期:2006-05-19 00:00:00
abstract:BACKGROUND:Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The "Thwaites' system" and "Lancet consensus scoring system" are utilized to differentiate TBM from bacterial meningitis but their utility in subacute and chronic meningitis where TBM is an important consideration is...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
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更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:Legionnaire's disease is one of the major causes of community-acquired pneumonia and is occasionally complicated by neurological symptoms. However, reports of ocular lesions due to Legionnaire's disease are limited. CASE PRESENTATION:We report the case of a patient with Legionnaire's disease presenting as b...
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更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is a major public health problem in developing countries like Bangladesh. Female sex workers (FSWs) and their clients are active sources for spreading TB. The purpose of this study was to assess the knowledge of TB among FSWs in Rajshahi city, Bangladesh. METHODS:It was a cross-sectional s...
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pub_type: 杂志文章
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更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:The inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates the need for acquirement of reliable and standard diagnostic reagents. Recently, epitope-based antigens have emerged as an alternative diagnostic marker for the achievemen...
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pub_type: 杂志文章
doi:10.1186/s12879-017-2920-9
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sample size. Hence this study aimed to estimate HBV seroprevalence using a large inpatient population ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4091-3
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from au...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) continues to be a public health challenge in Saudi Arabia, particularly for the elderly. This study was conducted to estimate mortality per 1000 person-year among TB and resistant TB cases and to identifying factors associated with mortality. METHODS:This is a retrospective cohort study of...
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pub_type: 杂志文章
doi:10.1186/s12879-019-4063-7
更新日期:2019-05-16 00:00:00
abstract::After publication of the original article [1], we were notified that two of the author names were incorrectly displayed in the pdf version of the paper, while one other name was incorrectly tagged in the XML version. ...
journal_title:BMC infectious diseases
pub_type: 已发布勘误
doi:10.1186/s12879-019-4003-6
更新日期:2019-05-27 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis is a pathogen of worldwide importance, causing more than 100 million cases of sexually transmitted infections annually. Whole-genome sequencing is a powerful high resolution tool that can be used to generate accurate data on bacterial population structure, phylogeography and mutations a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0591-3
更新日期:2014-11-12 00:00:00
abstract:BACKGROUND:Mycolicibacterium fortuitum is a species of the rapidly growing mycobacteria that can cause pulmonary infection. It is susceptible to multiple antibiotics both in vitro and in clinical practice, so that any combination of susceptible drugs is effective. However, we encountered a case of infection due to fluo...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05596-1
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Compared to methicillin-resistant Staphylococcus aureus (MRSA), characteristics of nasal carriage and community-onset infection methicillin-susceptible S. aureus (MSSA) are less well known. No characteristics of MSSA in Taiwan have been reported previously. METHODS:We analyzed 100 nasal carriage and 34 comm...
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doi:10.1186/1471-2334-12-343
更新日期:2012-12-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-017-2398-5
更新日期:2017-04-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-018-3312-5
更新日期:2018-08-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-019-3966-7
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doi:10.1186/s12879-020-05680-6
更新日期:2020-12-09 00:00:00
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doi:10.1186/s12879-020-4915-1
更新日期:2020-03-12 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2334-11-324
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pub_type: 杂志文章,meta分析
doi:10.1186/1471-2334-12-223
更新日期:2012-09-21 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-35
更新日期:2007-04-27 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-40
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-30 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) - a syndrome characterised by a shift in vaginal flora - appears to be particularly common in sub-Saharan Africa, but little is known of the pattern of vaginal flora associated with BV in Africa. We conducted a study aimed at determining the prevalence of BV and patterns of BV-associ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-12
更新日期:2005-03-09 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2019-01-08 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-03-16 00:00:00