Abstract:
BACKGROUND:Mycolicibacterium fortuitum is a species of the rapidly growing mycobacteria that can cause pulmonary infection. It is susceptible to multiple antibiotics both in vitro and in clinical practice, so that any combination of susceptible drugs is effective. However, we encountered a case of infection due to fluoroquinolone-resistant M. fortuitum. In this study, we report the case and describe the mechanism of resistance. CASE PRESENTATION:A 65-year-old man with a history of total gastrectomy and immunosuppressant treatment for rheumatoid arthritis developed a recurrence of pulmonary infection caused by M. fortuitum. He was treated with clarithromycin and levofloxacin as a first-line treatment, based on the favorable susceptibility at that time. After recurrence, a high minimum inhibitory concentration to fluoroquinolones was detected. DNA sequencing of the pathogen showed the substitution of serine for tryptophan at residue 83 in the gyrA gene. He was successfully treated with a combination of other antibiotics. CONCLUSION:This is the first report on the treatment of fluoroquinolone-resistant M. fortuitum and investigation of the mechanism of resistance. We suggest that the susceptibility test remains effective for determining the next line of treatment after a pathogen has acquired resistance, and resistance to fluoroquinolones in M. fortuitum can be attributed to a single change of amino acid.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Kurokawa K,Harada N,Sasano H,Takagi H,Takei S,Nakamura A,Kamada K,Yoshida A,Kikuchi K,Takahashi Kdoi
10.1186/s12879-020-05596-1subject
Has Abstractpub_date
2020-11-19 00:00:00pages
866issue
1issn
1471-2334pii
10.1186/s12879-020-05596-1journal_volume
20pub_type
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,meta分析
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2015-12-02 00:00:00
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