Pulmonary infection due to fluoroquinolone-resistant Mycolicibacterium fortuitum: a case report.

Abstract:

BACKGROUND:Mycolicibacterium fortuitum is a species of the rapidly growing mycobacteria that can cause pulmonary infection. It is susceptible to multiple antibiotics both in vitro and in clinical practice, so that any combination of susceptible drugs is effective. However, we encountered a case of infection due to fluoroquinolone-resistant M. fortuitum. In this study, we report the case and describe the mechanism of resistance. CASE PRESENTATION:A 65-year-old man with a history of total gastrectomy and immunosuppressant treatment for rheumatoid arthritis developed a recurrence of pulmonary infection caused by M. fortuitum. He was treated with clarithromycin and levofloxacin as a first-line treatment, based on the favorable susceptibility at that time. After recurrence, a high minimum inhibitory concentration to fluoroquinolones was detected. DNA sequencing of the pathogen showed the substitution of serine for tryptophan at residue 83 in the gyrA gene. He was successfully treated with a combination of other antibiotics. CONCLUSION:This is the first report on the treatment of fluoroquinolone-resistant M. fortuitum and investigation of the mechanism of resistance. We suggest that the susceptibility test remains effective for determining the next line of treatment after a pathogen has acquired resistance, and resistance to fluoroquinolones in M. fortuitum can be attributed to a single change of amino acid.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Kurokawa K,Harada N,Sasano H,Takagi H,Takei S,Nakamura A,Kamada K,Yoshida A,Kikuchi K,Takahashi K

doi

10.1186/s12879-020-05596-1

subject

Has Abstract

pub_date

2020-11-19 00:00:00

pages

866

issue

1

issn

1471-2334

pii

10.1186/s12879-020-05596-1

journal_volume

20

pub_type

杂志文章
  • Bordetella bronchiseptica pneumonia in a patient with lung cancer; a case report of a rare infection.

    abstract:BACKGROUND:Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case of B. bronchiseptica pneumonia in a patient with lung cancer. CASE PRESENTATION:A 52-year-old white male with non small cell lung cancer...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2736-7

    authors: Monti M,Diano D,Allegrini F,Delmonte A,Fausti V,Cravero P,Marcantognini G,Frassineti GL

    更新日期:2017-09-25 00:00:00

  • Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection.

    abstract:BACKGROUND:HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes of this activation, however, are incompletely understood. We investigated the activation status of CD4+ T cells specific for chronic herpes viruses and the non-persistent antigen tetanus toxoi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-100

    authors: Smith MZ,Bastidas S,Karrer U,Oxenius A

    更新日期:2013-02-25 00:00:00

  • Hepatitis A in Puglia (South Italy) after 10 years of universal vaccination: need for strict monitoring and catch-up vaccination.

    abstract:BACKGROUND:Raw seafood consumption was identified as the major risk factor for hepatitis A during the large epidemic of 1996 and 1997 in Puglia (South Italy). In Puglia, vaccination for toddlers and preadolescents has been recommended since 1998.The aim of the study was to evaluate the incidence, seroprevalence, molecu...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-271

    authors: Chironna M,Prato R,Sallustio A,Martinelli D,Tafuri S,Quarto M,Germinario C

    更新日期:2012-10-25 00:00:00

  • Prevalence of group B streptococcus among pregnant women and newborns at Hawassa University comprehensive specialized hospital, Hawassa, Ethiopia.

    abstract:BACKGROUND:Group B streptococcus (GBS) is reported as the leading cause of neonatal sepsis and meningitis. Newborns from GBS colonized pregnant women are at high risk of infection. METHOD:A Hospital based cross-sectional study was conducted at Hawassa University Comprehensive Specialized Hospital from November 05, 201...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3859-9

    authors: Ali MM,Woldeamanuel Y,Woldetsadik DA,Chaka TE,Fenta DA,Dinberu MT,Weldetensaye EK,Ismael SJ,Tadesse BT

    更新日期:2019-04-16 00:00:00

  • Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study.

    abstract:BACKGROUND:In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-47

    authors: Shimizu Y,Sunaga N,Dobashi K,Fueki M,Fueki N,Makino S,Mori M

    更新日期:2009-04-22 00:00:00

  • Molecular characteristics and clinical features of pediatric methicillin-susceptible Staphylococcus aureus infection in a medical center in northern Taiwan.

    abstract:BACKGROUND:There have been no reports regarding clinical features and molecular characteristics of childhood methicillin-susceptible Staphylococcus aureus (MSSA) infections in Taiwan. METHODS:We prospectively collected clinical S. aureus isolates from patients aged < 18 years in a university-affiliated hospital in 201...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4033-0

    authors: Chen YJ,Chen PA,Chen CJ,Huang YC

    更新日期:2019-05-10 00:00:00

  • May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis?

    abstract:BACKGROUND:Arthropod-borne viral encephalitis of diverse origins shows similar clinical symptoms, histopathology and magnetic resonance imaging, indicating that the patho mechanisms may be similar. There is no specific therapy to date. However, vaccination remains the best prophylaxis against a selected few. Regardless...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-306

    authors: Růžek D,Dobler G,Niller HH

    更新日期:2013-07-03 00:00:00

  • A prospective case-control and molecular epidemiological study of human cases of Shiga toxin-producing Escherichia coli in New Zealand.

    abstract:BACKGROUND:Shiga toxin-producing Escherichia coli (STEC) O157:H7 and related non-O157 STEC strains are enteric pathogens of public health concern worldwide, causing life-threatening diseases. Cattle are considered the principal hosts and have been shown to be a source of infection for both foodborne and environmental o...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-450

    authors: Jaros P,Cookson AL,Campbell DM,Besser TE,Shringi S,Mackereth GF,Lim E,Lopez L,Dufour M,Marshall JC,Baker MG,Hathaway S,Prattley DJ,French NP

    更新日期:2013-09-30 00:00:00

  • Modified genome comparison method: a new approach for identification of specific targets in molecular diagnostic tests using Mycobacterium tuberculosis complex as an example.

    abstract:BACKGROUND:The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve this goal. In this study, we aimed to explain this method with the example of Mycobacterium tubercul...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3417-x

    authors: Neshani A,Kamali Kakhki R,Sankian M,Zare H,Hooshyar Chichaklu A,Sayyadi M,Ghazvini K

    更新日期:2018-10-12 00:00:00

  • Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. METHODS:A five-year cross-sectional study was conducted in a tertiary children's hospital in Zheji...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05030-6

    authors: Shuai H,Bian Q,Luo Y,Zhou X,Song X,Ye J,Huang Q,Peng Z,Wu J,Jiang J,Jin D

    更新日期:2020-05-13 00:00:00

  • The liver fibrosis index is superior to the APRI and FIB-4 for predicting liver fibrosis in chronic hepatitis B patients in China.

    abstract:BACKGROUND:The purpose of this study was to prospectively investigate the value of real-time ultrasound elastography (RTE) for the diagnosis of liver fibrosis (LF) in patients with chronic hepatitis B (CHB), to correlate the elastography findings with the histologic stage of LF and to compare RTE findings with those fr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4459-4

    authors: Huang D,Lin T,Wang S,Cheng L,Xie L,Lu Y,Chen M,Zhu L,Shi J

    更新日期:2019-10-22 00:00:00

  • Oxidative stress markers in saliva and periodontal disease status: modulation during pregnancy and postpartum.

    abstract:BACKGROUND:Periodontal diseases may affect local and systemic inflammation, and reactive oxygen species (ROS) levels. This systemic health burden could compromise the outcome of pregnancy in expectant mothers. The aim of the present study was to evaluate oxidative stress markers, including glutathione peroxidase (GPx),...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1003-z

    authors: Gümüş P,Emingil G,Öztürk VÖ,Belibasakis GN,Bostanci N

    更新日期:2015-07-08 00:00:00

  • Diagnosis and subtype analysis of Blastocystis sp. in 442 patients in a hospital setting in the Netherlands.

    abstract:BACKGROUND:Blastocystis sp. are among the most commonly observed intestinal parasites in routine clinical parasitology. Blastocystis in humans consists of at least 9 genetic subtypes. Different subtypes of Blastocystis may be associated with differences in pathogenicity and symptomatology. METHODS:Advanced microscopy ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-389

    authors: Bart A,Wentink-Bonnema EM,Gilis H,Verhaar N,Wassenaar CJ,van Vugt M,Goorhuis A,van Gool T

    更新日期:2013-08-23 00:00:00

  • Clinical and molecular characteristics of invasive community-acquired Staphylococcus aureus infections in Chinese children.

    abstract:BACKGROUND:This study aims to investigate the clinical features of invasive community-acquired Staphylococcus aureus (CA-SA) infection in Chinese children and analyze its molecular features. METHODS:Clinical data and invasive CA-SA isolates were prospectively collected. Pediatric risk of mortality (PRISM) score was us...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-014-0582-4

    authors: Qiao Y,Ning X,Chen Q,Zhao R,Song W,Zheng Y,Dong F,Li S,Li J,Wang L,Zeng T,Dong Y,Yao K,Yu S,Yang Y,Shen X

    更新日期:2014-11-07 00:00:00

  • Young people's views on the potential use of telemedicine consultations for sexual health: results of a national survey.

    abstract:BACKGROUND:Young people are disproportionately affected by sexually transmissible infections in Australia but face barriers to accessing sexual health services, including concerns over confidentiality and, for some, geographic remoteness. A possible innovation to increase access to services is the use of telemedicine. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-285

    authors: Garrett CC,Hocking J,Chen MY,Fairley CK,Kirkman M

    更新日期:2011-10-25 00:00:00

  • Prevalence and associated factors of diabetes mellitus among tuberculosis patients in Hanoi, Vietnam.

    abstract:BACKGROUND:Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of DM and TB, especially in low- and middle-income countries. METHODS:A facility-based, cross-sectiona...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3519-5

    authors: Hoa NB,Phuc PD,Hien NT,Hoa VQ,Thuong PH,Anh PT,Nhung NV

    更新日期:2018-11-29 00:00:00

  • Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections.

    abstract:BACKGROUND:Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2567-6

    authors: Frassanito A,Nenna R,Nicolai A,Pierangeli A,Tozzi AE,Stefanelli P,Carsetti R,Concato C,Schiavoni I,Midulla F,Pertussis study group.

    更新日期:2017-07-12 00:00:00

  • The risk of infections in hematologic patients treated with rituximab is not influenced by cumulative rituximab dosage - a single center experience.

    abstract:BACKGROUND:Rituximab, a monoclonal antibody directed against CD20, is approved for the treatment of CD20-positive B-cell Non-Hodgkin's lymphoma and rheumatologic disorders. Due to its potent activity in depleting CD20-positive lymphocytes, the influence on opportunistic infections is still under discussion. Thus, we an...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-364

    authors: Nissen JC,Hummel M,Brade J,Kruth J,Hofmann WK,Buchheidt D,Reinwald M

    更新日期:2014-07-03 00:00:00

  • Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

    abstract:BACKGROUND:After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the dev...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3690-3

    authors: Zhang JW,Zhang XZ,Sun YL,Long B,Wang XZ,Li XD

    更新日期:2019-01-16 00:00:00

  • Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka.

    abstract:BACKGROUND:To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to e...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2165-z

    authors: Premaratna R,Blanton LS,Samaraweera DN,de Silva GN,Chandrasena NT,Walker DH,de Silva HJ

    更新日期:2017-01-13 00:00:00

  • Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

    abstract:BACKGROUND:Large scale administration of the anthelminthic drug praziquantel (PZQ) to at-risk populations is the cornerstone of schistosomiasis control, although persisting high prevalence of infections in some areas and growing concerns of PZQ resistance have revealed the limitations of this strategy. Most studies ass...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12879-018-3554-2

    authors: Hoekstra PT,Casacuberta Partal M,Amoah AS,van Lieshout L,Corstjens PLAM,Tsonaka S,Assaré RK,Silué KD,Meité A,N'Goran EK,N'Gbesso YK,Roestenberg M,Knopp S,Utzinger J,Coulibaly JT,van Dam GJ

    更新日期:2018-12-14 00:00:00

  • Nationwide trends in molecular epidemiology of methicillin-resistant Staphylococcus aureus, Finland, 1997-2004.

    abstract:BACKGROUND:In Finland, the annual number of MRSA notifications to the National Infectious Disease Register (NIDR) has constantly increased since 1995, and molecular typing has revealed numerous outbreak isolates of MRSA. We analyzed the data on MRSA notifications of the NIDR, and MRSA isolates were identified mainly by...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-94

    authors: Kerttula AM,Lyytikäinen O,Kardén-Lilja M,Ibrahem S,Salmenlinna S,Virolainen A,Vuopio-Varkila J

    更新日期:2007-08-14 00:00:00

  • Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model.

    abstract:BACKGROUND:Both cell-associated and cell-free HIV virions are present in semen and cervical secretions of HIV-infected individuals. Thus, topical microbicides may need to inactivate both cell-associated and cell-free HIV to prevent sexual transmission of HIV/AIDS. To determine if the mild acidity of the healthy vagina ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-5-79

    authors: Olmsted SS,Khanna KV,Ng EM,Whitten ST,Johnson ON 3rd,Markham RB,Cone RA,Moench TR

    更新日期:2005-09-30 00:00:00

  • Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study.

    abstract:BACKGROUND:Rilpivirine is safe and effective in HIV-naïve patients with low baseline HIV-RNA or in switch strategy. It offers the advantages of few drug-drug interactions and a favourable toxicity profile. We aimed to determine the reasons for prescribing the rilpivirine (RPV)/tenofovir disoproxil (TDF)/emtricitabine (...

    journal_title:BMC infectious diseases

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/s12879-017-2579-2

    authors: Sculier D,Gayet-Ageron A,Battegay M,Cavassini M,Fehr J,Hirzel C,Schmid P,Bernasconi E,Calmy A,Swiss HIV Cohort Study.

    更新日期:2017-07-06 00:00:00

  • Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature.

    abstract:BACKGROUND:Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-018-3284-5

    authors: Nakamura K,Saito K,Hara Y,Aoyagi T,Kitakawa K,Abe Y,Takemura H,Ikeda F,Kaku M,Kanemitsu K

    更新日期:2018-08-07 00:00:00

  • First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs.

    abstract:BACKGROUND:The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). METHODS:Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admis...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-015-1105-7

    authors: Ma X,Wu Y,Li L,Xu Q,Hu B,Ni Y,Wu A,Sun S,Jarlier V,Robert J

    更新日期:2015-08-21 00:00:00

  • Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993-2011: an observational study.

    abstract:BACKGROUND:Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norwa...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1553-8

    authors: Askim Å,Mehl A,Paulsen J,DeWan AT,Vestrheim DF,Åsvold BO,Damås JK,Solligård E

    更新日期:2016-05-23 00:00:00

  • Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

    abstract:BACKGROUND:Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-019-4390-8

    authors: Guo P,Liu S,Sun X,Xu L

    更新日期:2019-08-30 00:00:00

  • High prevalence of Bordetella pertussis in children under 5 years old hospitalized with acute respiratory infections in Lima, Peru.

    abstract:BACKGROUND:Pertussis diagnosis may go unrecognized when other pathogens, such as respiratory syncytial virus (RSV) circulate. METHODS:A prospective cross-sectional study was conducted in Lima, Peru from January 2009 to September 2010. A total of 596 children under 5 years old admitted with clinical diagnoses of acute ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1287-z

    authors: Pavic-Espinoza I,Bendezú-Medina S,Herrera-Alzamora A,Weilg P,Pons MJ,Aguilar-Luis MA,Petrozzi-Helasvuo V,del Valle Mendoza J

    更新日期:2015-12-02 00:00:00

  • An atypical winter outbreak of hand, foot, and mouth disease associated with human enterovirus 71, 2010.

    abstract:BACKGROUND:To analyze the epidemiological characteristics and pathogenic molecular characteristics of an hand, foot, and mouth disease (HFMD) outbreak caused by enterovirus 71 in Linyi City, Shandong Province, China during November 30 to December 28, 2010. METHODS:One hundred and seventy three stool specimens and 40 t...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-123

    authors: Liu N,Xie J,Qiu X,Jia L,Wu Z,Ma Y,Wang Z,Li P,Ren X,Hao R,Wang L,Wang Y,Qiu S,Song H

    更新日期:2014-03-04 00:00:00