Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis.

Abstract:

BACKGROUND:Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases. METHODS:In this study we evaluated the in vitro toxicity of nitric oxide for the promastigote stages of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis parasites, and the infectivity of the amastigote stage for human macrophages. Parasites were isolated from patients with cutaneous, mucosal or disseminated leishmaniasis, and NO* resistance was correlated with clinical presentation. RESULTS:Seventeen isolates of L. (L.) amazonensis or L. (V.) braziliensis promastigotes were killed by up to 8 mM of more of NaNO2 (pH 5.0) and therefore were defined as nitric oxide-susceptible. In contrast, eleven isolates that survived exposure to 16 mM NaNO2 were defined as nitric oxide-resistant. Patients infected with nitric oxide-resistant Leishmania had significantly larger lesions than patients infected with nitric oxide-susceptible isolates. Furthermore, nitric oxide-resistant L. (L.) amazonensis and L. (V.) braziliensis multiplied significantly better in human macrophages than nitric oxide-susceptible isolates. CONCLUSION:These data suggest that nitric oxide-resistance of Leishmania isolates confers a survival benefit for the parasites inside the macrophage, and possibly exacerbates the clinical course of human leishmaniasis.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Giudice A,Camada I,Leopoldo PT,Pereira JM,Riley LW,Wilson ME,Ho JL,de Jesus AR,Carvalho EM,Almeida RP

doi

10.1186/1471-2334-7-7

subject

Has Abstract

pub_date

2007-02-22 00:00:00

pages

7

issn

1471-2334

pii

1471-2334-7-7

journal_volume

7

pub_type

杂志文章
  • Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya.

    abstract:BACKGROUND:In resource-limited settings, such as Kenya, access to CD4 testing is limited. Therefore, evaluation of less expensive laboratory diagnostics is urgently needed to diagnose immuno-suppression in children. OBJECTIVES:To evaluate utility of total lymphocyte count (TLC) as surrogate marker for CD4 count in HIV...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-259

    authors: Githinji N,Maleche-Obimbo E,Nderitu M,Wamalwa DC,Mbori-Ngacha D

    更新日期:2011-09-30 00:00:00

  • Patient delay in the diagnosis of tuberculosis in Ethiopia: a systematic review and meta-analysis.

    abstract:BACKGROUND:Delay in the diagnosis of Tuberculosis (TB) remains a major challenge against achieving effective TB prevention and control. Though a number of studies with inconsistent findings were conducted in Ethiopia; unavailability of a nationwide study determining the median time of patient delays to TB diagnosis is ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-020-05524-3

    authors: Alene M,Assemie MA,Yismaw L,Gedif G,Ketema DB,Gietaneh W,Chekol TD

    更新日期:2020-10-27 00:00:00

  • Central-line associated bloodstream infections in a tertiary care children's University hospital: a prospective study.

    abstract:BACKGROUND:The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2061-6

    authors: Venturini E,Montagnani C,Benni A,Becciani S,Biermann KP,De Masi S,Chiappini E,de Martino M,Galli L,CLABSI (central-line associated bloodstream infections) study group.

    更新日期:2016-12-01 00:00:00

  • Factors associated with cytomegalovirus serostatus in young people in England: a cross-sectional study.

    abstract:BACKGROUND:Human cytomegalovirus (CMV) is a common herpesvirus which is estimated to infect 83% of the global population. Whilst many infections are asymptomatic, it is an important cause of morbidity and mortality, particularly for immunocompromised people and for infants who are congenitally infected. A vaccine again...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05572-9

    authors: Winter JR,Taylor GS,Thomas OG,Jackson C,Lewis JEA,Stagg HR

    更新日期:2020-11-23 00:00:00

  • Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia.

    abstract:BACKGROUND:This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children in Ethiopia. METHODS:We model the mosquito abundance and time to malaria data jointly in a Bayesian framework. RE...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2496-4

    authors: Belay DB,Kifle YG,Goshu AT,Gran JM,Yewhalaw D,Duchateau L,Frigessi A

    更新日期:2017-06-12 00:00:00

  • Epidemiology of laboratory confirmed measles virus cases in the southern nations of Ethiopia, 2007-2014.

    abstract:BACKGROUND:In Ethiopia, measles case-based surveillance was introduced in 2004 as one strategy for measles control by laboratory confirmation of suspected cases. In this article, epidemiological distribution of laboratory-confirmed measles cases were reported from the Southern Nation Nationalities and Peoples Region (S...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2183-5

    authors: Getahun M,Beyene B,Ademe A,Teshome B,Tefera M,Afework A,HaileMariam Y,Assefa E,Hailegiorgis Y,Asha A

    更新日期:2017-01-19 00:00:00

  • Multidrug-resistant Mycobacterium tuberculosis: a report of cosmopolitan microbial migration and an analysis of best management practices.

    abstract:BACKGROUND:Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB is being threatened by the increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series of seven MDR-TB cases in migrant patients with identical Mycobacterium tuberculosis strains we aim to illu...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05381-0

    authors: Joean O,Thiele T,Schütz K,Schwerk N,Sedlacek L,Kalsdorf B,Baumann U,Stoll M

    更新日期:2020-09-17 00:00:00

  • Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site.

    abstract:BACKGROUND:HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV d...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2937-0

    authors: Vergori A,Garbuglia AR,Piselli P,Del Nonno F,Sias C,Lupi F,Lapa D,Baiocchini A,Cimaglia C,Gentile M,Antinori A,Capobianchi M,Ammassari A

    更新日期:2018-01-08 00:00:00

  • Schistosomiasis and HIV-1 viral load in HIV-infected outpatients with immunological failure in Tanzania: a case-control study.

    abstract:BACKGROUND:Schistosoma sp. infection has been shown to interact with HIV-1 by modifying susceptibility to the virus and impacting AIDS outcome, but very little is known about the potential impact of Schistosoma sp. infection on the efficiency of antiretroviral treatment (ART) in HIV-1 infected individuals. One study su...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3876-8

    authors: Masikini P,Colombe S,Marti A,Desderius B,de Dood CJ,Corstjens PLAM,van Dam GJ,Seugendo M,Kalluvya S,Downs JA

    更新日期:2019-03-12 00:00:00

  • Missed opportunities for HIV testing in newly-HIV-diagnosed patients, a cross sectional study.

    abstract:BACKGROUND:In France, 1/3 HIV-infected patients is diagnosed at an advanced stage of the disease. We describe missed opportunities for earlier HIV testing in newly-HIV-diagnosed patients. METHODS:Cross sectional study. Adults living in France for ≥1 year, diagnosed with HIV-infection ≤6 months earlier, were included f...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-200

    authors: Champenois K,Cousien A,Cuzin L,Le Vu S,Deuffic-Burban S,Lanoy E,Lacombe K,Patey O,Béchu P,Calvez M,Semaille C,Yazdanpanah Y

    更新日期:2013-05-02 00:00:00

  • Imported loiasis in France: a retrospective analysis of 167 cases with comparison between sub-Saharan and non sub-Saharan African patients.

    abstract:BACKGROUND:Imported loiasis is a rare cause of consultation at the return of stay in central Africa, which often poses difficult diagnostic and therapeutic questions to practitioners especially those who are unaccustomed to tropical medicine. These difficulties can lead to risks for the patients especially if inappropr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4740-6

    authors: Bouchaud O,Matheron S,Loarec A,Dupouy Camet J,Bourée P,Godineau N,Poilane I,Cailhol J,Caumes E

    更新日期:2020-01-20 00:00:00

  • Are current case-finding methods under-diagnosing tuberculosis among women in Myanmar? An analysis of operational data from Yangon and the nationwide prevalence survey.

    abstract:BACKGROUND:Although there is a large increase in investment for tuberculosis control in Myanmar, there are few operational analyses to inform policies. Only 34% of nationally reported cases are from women. In this study, we investigate sex differences in tuberculosis diagnoses in Myanmar in order to identify potential ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1429-y

    authors: Khan MS,Khine TM,Hutchison C,Coker RJ,Hane KM,Innes AL,Aung S

    更新日期:2016-03-03 00:00:00

  • The general status of patients and limited physical activity as risk factors of Methicillin-resistant Staphylococcus aureus occurrence in long-term care facilities residents in Krakow, Poland.

    abstract:BACKGROUND:The aim of this study was to investigate the epidemiology and resistance of methicillin-resistant Staphylococcus aureus (MRSA) isolates from long-term care facilities (LTCF) residents and to analyze the potential risk factors for MRSA occurrence, defined as MRSA colonization and/or infection. METHODS:Point ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-14-271

    authors: Romaniszyn D,Pobiega M,Wójkowska-Mach J,Chmielarczyk A,Gryglewska B,Adamski P,Heczko PB,Ochońska D,Bulanda M

    更新日期:2014-05-18 00:00:00

  • 26Postoperative diagnosis and outcome in patients with revision arthroplasty for aseptic loosening.

    abstract:BACKGROUND:The most common cause of implant failure is aseptic loosening (AL), followed by prosthetic joint infection (PJI). This study evaluates the incidence of PJI among patients operated with suspected AL and whether the diagnosis of PJI was predictive of subsequent implant failure including re-infection, at 2 year...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0976-y

    authors: Fernandez-Sampedro M,Salas-Venero C,Fariñas-Álvarez C,Sumillera M,Pérez-Carro L,Fakkas-Fernandez M,Gómez-Román J,Martínez-Martínez L,Fariñas MC

    更新日期:2015-06-18 00:00:00

  • Multifocal motor neuropathy presenting as a post-infectious complication of dengue: a CASE report.

    abstract:BACKGROUND:Dengue infection is an endemic illness in the tropics and it is associated with a wide variety of post infectious complications. With the increasing prevalence of dengue infection in endemic regions, post-infectious neurological complications following dengue infection are now been reported more frequently. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3334-z

    authors: Higgoda R,Perera D,Thirumavalavan K

    更新日期:2018-08-22 00:00:00

  • Cross-sectional study of hepatitis B virus infection in rural communities, Central African Republic.

    abstract:BACKGROUND:As most data on hepatitis in resource-poor countries relate to urban communities, surveys in the rural environment are necessary to determine the 'true' prevalence of these viral infections. We undertook a survey to determine the prevalence of hepatitis B virus (HBV) infection in an apparently healthy rural ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-286

    authors: Komas NP,Vickos U,Hübschen JM,Béré A,Manirakiza A,Muller CP,Le Faou A

    更新日期:2013-06-24 00:00:00

  • Relationship between day 1 and day 2 Vancomycin area under the curve values and emergence of heterogeneous Vancomycin-intermediate Staphylococcus aureus (hVISA) by Etest® macromethod among patients with MRSA bloodstream infections: a pilot study.

    abstract:BACKGROUND:In vitro data suggests that suboptimal initial vancomycin exposure may select for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) infections. However, no clinical studies have evaluated the relationship between initial vancomycin exposure and emergence of hVISA. This pilot study seeks to ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2609-0

    authors: Martirosov DM,Bidell MR,Pai MP,Scheetz MH,Rosenkranz SL,Faragon C,Malik M,Mendes RE,Jones RN,McNutt LA,Lodise TP

    更新日期:2017-08-02 00:00:00

  • The impact of community-acquired pneumonia on the health-related quality-of-life in elderly.

    abstract:BACKGROUND:The sustained health-related quality-of-life of patients surviving community-acquired pneumonia has not been accurately quantified. The aim of the current study was to quantify differences in health-related quality-of-life of community-dwelling elderly with and without community-acquired pneumonia during a 1...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2302-3

    authors: Mangen MJ,Huijts SM,Bonten MJ,de Wit GA

    更新日期:2017-03-14 00:00:00

  • Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients.

    abstract:BACKGROUND:Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with inva...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-11-60

    authors: Pemán J,Zaragoza R,Quindós G,Alkorta M,Cuétara MS,Camarena JJ,Ramírez P,Giménez MJ,Martín-Mazuelos E,Linares-Sicilia MJ,Pontón J,study group Candida albicans Germ Tube Antibody Detection in Critically Ill Patients.

    更新日期:2011-03-09 00:00:00

  • High Mycoplasma pneumoniae loads and persistent long-term Mycoplasma pneumoniae DNA in lower airway associated with severity of pediatric Mycoplasma pneumoniae pneumonia.

    abstract:BACKGROUND:An increased number of refractory mycoplasma pneumoniae (MP) pneumonia (MPP) cases have been reported. However the duration of MP infection in lower airway and the course of anti-MP treatment remains unclear. METHODS:We retrospectively reviewed the medical records of 94 MPP children. Patients were classifie...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4667-y

    authors: Liu J,Zhao F,Lu J,Xu H,Liu H,Tang X,Yang H,Zhang J,Zhao S

    更新日期:2019-12-10 00:00:00

  • Prevalence, predictors, and management of advanced HIV disease among individuals initiating ART in Senegal, West Africa.

    abstract:BACKGROUND:The WHO guidelines for the management of advanced HIV disease recommend a package of care consisting of rapid initiation of antiretroviral therapy (ART), enhanced screening and diagnosis of tuberculosis (TB) and cryptococcal meningitis, co-trimoxazole prophylaxis, isoniazid preventive therapy (IPT), fluconaz...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3826-5

    authors: Benzekri NA,Sambou JF,Ndong S,Tamba IT,Faye D,Diallo MB,Diatta JP,Faye K,Sall I,Sall F,Manga NM,Malomar JJ,Ndour CT,Hawes SE,Seydi M,Gottlieb GS

    更新日期:2019-03-15 00:00:00

  • Characteristics of invasive Acinetobacter species isolates recovered in a pediatric academic center.

    abstract:BACKGROUND:Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-bauma...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1678-9

    authors: Jain AL,Harding CM,Assani K,Shrestha CL,Haga M,Leber A,Munson RS Jr,Kopp BT

    更新日期:2016-07-22 00:00:00

  • Association between early bacterial carriage and otitis media in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia: a cohort study.

    abstract:BACKGROUND:Streptococcus pneumoniae (Pnc), nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are the most important bacterial pathogens associated with otitis media (OM). Previous studies have suggested that early upper respiratory tract (URT) bacterial carriage may increase risk of subsequent ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-366

    authors: Sun W,Jacoby P,Riley TV,Bowman J,Leach AJ,Coates H,Weeks S,Cripps A,Lehmann D,Kalgoorlie Otitis Media Research Project Team.

    更新日期:2012-12-21 00:00:00

  • Epidemiological analysis of the Kaohsiung city strategy for dengue fever quarantine and epidemic prevention.

    abstract:BACKGROUND:Dengue is endemic in over 100 countries and is an important public health problem worldwide. Dengue fever is not endemic in Taiwan; the importation of dengue viruses from neighboring countries via close commercial links and air travel is considered to be the cause of local outbreaks. Therefore, efforts towar...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-4942-y

    authors: Pan CY,Liu WL,Su MP,Chang TP,Ho HP,Shu PY,Huang JJ,Lin LJ,Chen CH

    更新日期:2020-05-15 00:00:00

  • Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials.

    abstract:BACKGROUND:Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity between GlaxoSmithKline Vaccines' A/California/7/2009 (H1N1)v-like-AS03 vaccines manufactured in Dresden ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2334-13-435

    authors: Launay O,Duval X,Fitoussi S,Jilg W,Kerdpanich A,Montellano M,Schwarz TF,Watanveerade V,Wenzel JJ,Zalcman G,Bambure V,Li P,Caplanusi A,Madan A,Gillard P,Vaughn DW

    更新日期:2013-09-16 00:00:00

  • Mitigating effects of vaccination on influenza outbreaks given constraints in stockpile size and daily administration capacity.

    abstract:BACKGROUND:Influenza viruses are a major cause of morbidity and mortality worldwide. Vaccination remains a powerful tool for preventing or mitigating influenza outbreaks. Yet, vaccine supplies and daily administration capacities are limited, even in developed countries. Understanding how such constraints can alter the ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-207

    authors: Cruz-Aponte M,McKiernan EC,Herrera-Valdez MA

    更新日期:2011-08-01 00:00:00

  • Transmission dynamics for Methicilin-resistant Staphalococous areus with injection drug user.

    abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen resistance to antibiotics including methicillin. The resistance first emerged in 1960 in a healthcare setting only after two years of using methicillin as a viable treatment for methicillin-susceptible Staphylococcus aureus. MRSA lead...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-2973-4

    authors: Wagner R,Agusto FB

    更新日期:2018-02-07 00:00:00

  • Empiric treatment against invasive fungal diseases in febrile neutropenic patients: a systematic review and network meta-analysis.

    abstract:BACKGROUND:The most optimal antifungal agent for empiric treatment of invasive fungal diseases (IFDs) in febrile neutropenia is controversial. Our objective was evaluate the relative efficacy of antifungals for all-cause mortality, fungal infection-related mortality and treatment response in this population. METHODS:P...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12879-017-2263-6

    authors: Chen K,Wang Q,Pleasants RA,Ge L,Liu W,Peng K,Zhai S

    更新日期:2017-02-20 00:00:00

  • First report on cutaneous infectious granuloma caused by Schizophyllum commune.

    abstract:BACKGROUND:Schizophyllum commune, a basidiomycetous fungus, is a common invader of rotten wood. This fungus rarely causes mycotic disease in humans, especially cutaneous infection. In this paper, we describe the first case of cutaneous granuloma caused by S. commune in a Chinese woman. CASE PRESENTATION:A 25-year-old ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3187-5

    authors: Tian L,Mu Y,Zhang H,Su X,Yang C,Shu X,Qing D

    更新日期:2018-06-26 00:00:00

  • Evaluation of HIV-1 rapid tests and identification of alternative testing algorithms for use in Uganda.

    abstract:INTRODUCTION:The World Health Organization recommends that countries conduct two phase evaluations of HIV rapid tests (RTs) in order to come up with the best algorithms. In this report, we present the first ever such evaluation in Uganda, involving both blood and oral based RTs. The role of weak positive (WP) bands on ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3001-4

    authors: Kaleebu P,Kitandwe PK,Lutalo T,Kigozi A,Watera C,Nanteza MB,Hughes P,Musinguzi J,Opio A,Downing R,Mbidde EK

    更新日期:2018-02-27 00:00:00