Abstract:
BACKGROUND:The most common cause of implant failure is aseptic loosening (AL), followed by prosthetic joint infection (PJI). This study evaluates the incidence of PJI among patients operated with suspected AL and whether the diagnosis of PJI was predictive of subsequent implant failure including re-infection, at 2 years of follow up. METHODS:Patients undergoing revision hip or knee arthroplasty due to presumed AL from February 2009 to September 2011 were prospectively evaluated. A sonication fluid of prosthesis and tissue samples for microbiology and histopathology at the time of the surgery were collected. Implant failure include recurrent or persistent infection, reoperation for any reason or need for chronic antibiotic suppression. RESULTS:Of 198 patients with pre-and intraoperative diagnosis of AL, 24 (12.1 %) had postoperative diagnosis of PJI. After a follow up of 31 months (IQR: 21 to 38 months), 9 (37.5 %) of 24 patients in the PJI group had implant failure compared to only 1 (1.1 %) in the 198 of AL group (p < 0.0001). Sensitivity of sonicate fluid culture (>20 CFU) and peri-prosthetic tissue culture were 87.5 % vs 66.7 %, respectively. Specificities were 100 % for both techniques (95 % CI, 97.9-100 %). A greater number of patients with PJI (79.1 %) had previous partial arthroplasty revisions than those patients in the AL group (56.9 %) (p = 0.04). In addition, 5 (55.5 %) patients with PJI and implant failure had more revision arthroplasties during the first year after the last implant placement than those patients with PJI without implant failure (1 patient; 6.7 %) (RR 3.8; 95 % CI 1.4-10.1; p = 0.015). On the other hand, 6 (25 %) patients finally diagnosed of PJI were initially diagnosed of AL in the first year after primary arthroplasty, whereas it was only 16 (9.2 %) patients in the group of true AL (RR 2.7; 95 % CI 1.2-6.1; p = 0.03). CONCLUSIONS:More than one tenth of patients with suspected AL are misdiagnosed PJI. Positive histology and positive peri-implant tissue and sonicate fluid cultures are highly predictive of implant failure in patients with PJI. Patients with greater number of partial hip revisions for a presumed AL had more risk of PJI. Early loosening is more often caused by hidden PJI than late loosening.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Fernandez-Sampedro M,Salas-Venero C,Fariñas-Álvarez C,Sumillera M,Pérez-Carro L,Fakkas-Fernandez M,Gómez-Román J,Martínez-Martínez L,Fariñas MCdoi
10.1186/s12879-015-0976-ysubject
Has Abstractpub_date
2015-06-18 00:00:00pages
232issn
1471-2334pii
10.1186/s12879-015-0976-yjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:Antiretroviral therapy markedly reduced mortality in HIV-infected individuals. However, in the previous studies, up to 50% of patients are compelled to modify their regimen in middle and low-income countries where salvage drug is still limited. This cohort study aimed to investigate the incidence and predict...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0565-5
更新日期:2014-10-30 00:00:00
abstract:BACKGROUND:Haemophilus influenzae type b (Hib) vaccination led to a significant decrease in invasive bacterial infections in children. The aim of this study was to assess a potential shift to more non-type b invasive infections in a population with high Hib vaccination coverage and to compare the burden of suffering be...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-45
更新日期:2009-04-20 00:00:00
abstract:BACKGROUND:Libya is one of the largest countries in Africa and has the longest coast in the Mediterranean basin facing southern Europe. High rates of prevalence of viral hepatitis have been observed in various regions in Africa, but the prevalence in Libya is not well documented. We report on a large-scale nationwide s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-17
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:Streptococcus pneumoniae is a leading cause of morbidity and mortality in the elderly. To prevent invasive pneumococcal diseases, the 23-valent pneumococcal polysaccharide vaccine (PPV) is recommended in subjects over 65 years of age. Although it has been reported to provide approximately 50-80% protection a...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2334-10-60
更新日期:2010-03-10 00:00:00
abstract:BACKGROUND:Substantial numbers of patients are now receiving either immunosuppressive therapies or chemotherapy. There are significant risks in such patients of developing opportunistic infections or re-activation of latent infections, with higher associated morbidity and mortality. The aim of this quality improvement ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05082-8
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Enterocytozoon bieneusi has been increasingly reported to infect humans and various mammals. Microsporidia cause diarrhea in HIV-infected patients worldwide. PCR amplification and sequencing based on the internal transcribed spacer region have been used to describe the genotypes of E. bieneusi and transmissi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2787-9
更新日期:2017-10-13 00:00:00
abstract:BACKGROUND:Local understandings of malaria and use of preventive measures-are critical factors in sustained control of malaria. This study assessed caretakers' knowledge on malaria, use of Long Lasting Insecticide Treated Nets (LLINs) and care-seeking behavior for their children's illness in different malaria transmiss...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2731-z
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS:Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identif...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2153-3
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) DNA levels are crucial for managing chronic hepatitis B (CHB). It was unclear whether Daan real-time polymerase chain reaction test (Daan test) or COBAS TaqMan HBV DNA Test (Cobas TaqMan) was superior in measuring different HBV DNA levels in clinical specimens. METHODS:We enrolled 67...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-14-85
更新日期:2014-02-14 00:00:00
abstract:BACKGROUND:The risk factors, microbial etiology, differentiation, and clinical features of purulent and non-purulent cellulitis are not well defined in Taiwan. METHODS:We conducted a retrospective cohort study of hospitalized adults with cellulitis in Taiwan in 2013. The demographic characteristics, underlying disease...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1064-z
更新日期:2015-08-05 00:00:00
abstract:BACKGROUND:In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS:The case definition was that a child with onychomadesis or transverse ridging (Beau's line) in fingernails and toenails without ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4560-8
更新日期:2019-11-26 00:00:00
abstract:BACKGROUND:Efficient control and management in the ongoing COVID-19 pandemic needs to carefully balance economical and realizable interventions. Simulation models can play a cardinal role in forecasting possible scenarios to sustain decision support. METHODS:We present a sophisticated extension of a classical SEIR mod...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05566-7
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Bronchiolitis is considered one of the earliest and most common causes of hospitalisation in young children. Development of molecular technologies allowed a better understanding of bronchiolitis aetiology. Results from cohort studies evaluating the association between single, multiple viral infections and cl...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2225-z
更新日期:2017-02-13 00:00:00
abstract:BACKGROUND:This retrospective study evaluated the performance of a lipoarabinomannan (LAM)-based immunological method for diagnosing pleural tuberculosis (TB) from pleural effusion samples. Results were compared to those obtained using conventional culture and molecular testing methods. METHODS:Suspected pleural TB pa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4166-1
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:The mobility of female sex workers (FSWs) is a factor in the geographic spread of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). This study describes FSW mobility patterns in a high risk area of China to identify factors associated with increased mobility, and to study t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-198
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of DM and TB, especially in low- and middle-income countries. METHODS:A facility-based, cross-sectiona...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3519-5
更新日期:2018-11-29 00:00:00
abstract:BACKGROUND:Information about improvements in the health status of population at-risk of helminth infection after anthelminthic treatment helps to evaluate the effectiveness of the large scale deworming program. The objectives of this study were to assess the impact of anthelminthic treatment on the prevalence and inten...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1956-6
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:Recent analysis of trends of non-invasive infections with methicillin resistant Staphylococcus aureus (MRSA), of trends of MRSA infections in outpatient settings and of co-resistance profiles of MRSA isolates are scarce or lacking in Germany. METHODS:We analysed data from the Antimicrobial Resistance Survei...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2271-6
更新日期:2017-02-23 00:00:00
abstract:BACKGROUND:HPV burden is a predictor for high-grade cervical intraepithelial neoplasia and cancer. The natural history of HPV load in young women being recently exposed to HPV is described in this paper. METHODS:A total of 636 female university students were followed for 2 years. Cervical specimens with HPV-16, -18, -...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-326
更新日期:2010-11-11 00:00:00
abstract:BACKGROUND:There have been no reports regarding clinical features and molecular characteristics of childhood methicillin-susceptible Staphylococcus aureus (MSSA) infections in Taiwan. METHODS:We prospectively collected clinical S. aureus isolates from patients aged < 18 years in a university-affiliated hospital in 201...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4033-0
更新日期:2019-05-10 00:00:00
abstract:BACKGROUND:Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy indi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3832-7
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:In Lao PDR, the epidemiology of varicella infection is uncertain, since it is not a notifiable disease and VZV outbreaks are rarely reported as fever/rash (F/R) diseases. METHODS:We estimated the seroprevalence of VZV (IgG ELISA) in different age cohorts (9 months to 46 years; N = 3139) and investigated VZV...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3990-7
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Group B streptococcus (GBS) is reported as the leading cause of neonatal sepsis and meningitis. Newborns from GBS colonized pregnant women are at high risk of infection. METHOD:A Hospital based cross-sectional study was conducted at Hawassa University Comprehensive Specialized Hospital from November 05, 201...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3859-9
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Non-touch fittings have been reported to be susceptible for Pseudomonas aeruginosa accumulation. A number of factors may contribute to this, including the frequency of usage, duration of water stagnation, or presence of plastic materials. Programmable non-touch fittings are appearing which allow regular auto...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-402
更新日期:2013-08-30 00:00:00
abstract:BACKGROUND:Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norwa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1553-8
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. METHODS:In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-526
更新日期:2013-11-08 00:00:00
abstract:BACKGROUND:Clinical outcomes of spontaneous bacterial peritonitis (SBP) due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have not been adequately investigated. METHODS:We conducted a retrospective matched case-control study to evaluate the outcomes of SBP due to ESBL-...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-41
更新日期:2009-04-12 00:00:00
abstract:BACKGROUND:Incomplete virologic suppression results in mutations associated with resistance and is a major obstacle to disease control. We analyzed the genotypic profiles of HIV-1 patients at the time of the first virologic failure and the response to a salvage regimen after 48 weeks. METHODS:This work was a cross-sec...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3400-6
更新日期:2018-10-12 00:00:00
abstract:BACKGROUND:There is paucity of data on seasonal variation in pulmonary tuberculosis (TB) in developing countries contrary to recognized seasonality in the TB notification in western societies. This study examined the seasonal pattern in TB diagnosis among migrant workers from developing countries entering Kuwait. METH...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-3
更新日期:2008-01-07 00:00:00
abstract:BACKGROUND:Although breast-feeding accounts for 15-20% of mother-to-child transmission (MTCT) of HIV, it is not prohibited in some developing countries because of the higher mortality associated with not breast-feeding. We assessed the potential impact, on HIV infection and infant mortality, of a recommendation for sho...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-66
更新日期:2008-05-16 00:00:00