Abstract:
BACKGROUND:In Lao PDR, the epidemiology of varicella infection is uncertain, since it is not a notifiable disease and VZV outbreaks are rarely reported as fever/rash (F/R) diseases. METHODS:We estimated the seroprevalence of VZV (IgG ELISA) in different age cohorts (9 months to 46 years; N = 3139) and investigated VZV and 6 other viruses in patients during F/R outbreaks and in an ad hoc sentinel site in the context of the national reporting system (IgM ELISA, PCR). RESULTS:At least 80% of the sampled population had evidence of VZV infection before the age of 15. The largest increase in seroprevalence occurred between the age groups 1 to 5 and 6 to 7 year-olds. A VZV outbreak (clade 2) also occurred in this age group mostly during the first year of primary school (median age 6 years, interquartile range 4.0-7.5). During a dengue outbreak, 6% had varicella. At our F/R sentinel site, 14% of children with viral etiology were laboratory diagnosed as varicella and among others, a sizeable number of measles (N = 12) and rubella cases (N = 25) was detected compared to those reported for the whole country (N = 56 and 45), highlighting nationwide a large challenge of underreporting or misdiagnosis of these notifiable diseases because of lack of diagnostic laboratory capacity. CONCLUSION:We recommend strengthening the clinical and laboratory diagnosis of VZV, measles and rubella, the surveillance and reporting of notifiable F/R diseases by retraining of healthcare workers and by setting up sentinel sites and enhancing laboratory capacity.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Nouanthong P,Hübschen JM,Billamay S,Mongkhoune S,Vilivong K,Khounvisith V,Sinner R,Grandadam M,Phonekeo D,Black AP,Muller CPdoi
10.1186/s12879-019-3990-7subject
Has Abstractpub_date
2019-05-08 00:00:00pages
392issue
1issn
1471-2334pii
10.1186/s12879-019-3990-7journal_volume
19pub_type
杂志文章abstract:BACKGROUND:HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV d...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2937-0
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Human Parainfluenza Virus (hPIV) causes severe respiratory illness in infants and adults. Our study describes the association of hPIV1-4 with bronchiolitis, croup, and pneumonia using retrospective laboratory, administrative and public health data. Due to issues including the historic lack of hPIV4 in some c...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1748-z
更新日期:2016-08-11 00:00:00
abstract:BACKGROUND:Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative a...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-014-0635-8
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:The federal state of Hesse, Germany, introduced a laboratory-based reporting scheme for carbapenem-resistant organisms (CROs). METHOD:The results of the first year of mandated reporting of CROs from April 2012 through March 2013 to the Public Health Authority of Frankfurt/Main, responsible for a population ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-446
更新日期:2014-08-19 00:00:00
abstract:BACKGROUND:Carbapenemase-producing organisms (CPOs) have emerged as antibiotic-resistant bacteria of global concern. Here we assessed the performance of the Carba (beta) assay, a multiplex real-time PCR assay developed by SpeeDx for the detection of key carbapenemase-encoding genes: KPC, NDM, OXA-48-like, IMP-4-like, a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4176-z
更新日期:2019-07-02 00:00:00
abstract:BACKGROUND:Bloodstream infection (BSI) due to Pseudomonas aeruginosa (Pa) has relevant clinical impact especially in relation to drug resistance determinants. The PER-1 extended-spectrum beta-lactamase (ESBL) is a common enzyme conferring high-level resistance to anti-pseudomonal cephalosporins. Risk factors and treatm...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-52
更新日期:2006-03-16 00:00:00
abstract:BACKGROUND:Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acyclovir are currently used in anti-HSV therapies; however, clinical overuse of these drugs has led to...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2305-0
更新日期:2017-03-20 00:00:00
abstract:BACKGROUND:Routine culture-based diagnosis of Pseudomonas aeruginosa lung infection in Cystic Fibrosis (CF) patients can be hampered by the phenotypic variability of the microorganism, including its transition to a Viable But Non-Culturable (VBNC) state. The aim of this study was to validate an ecfX-targeting qPCR prot...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3612-9
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:Antibiotic resistant strains of Acinetobacter baumannii have been responsible for an increasing number of nosocomial infections including bacteremia and ventilator-associated pneumonia. In this study, we analyzed 38 isolates of A. baumannii obtained from two hospital outbreaks in Los Angeles County for the m...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1526-y
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:HIV-uninfected infants born to HIV-infected mothers (HIV-exposed uninfected, HEU) have been described to have immune alterations as compared to unexposed infants. This study sought to characterize T-cell populations after birth in HEU infants and unexposed infants living in a semirural area in southern Mozam...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0766-6
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:To reach non-participants, reluctant to undergo clinician-based cervical cancer screening and vaginal self-sampling, urine collection for high-risk human papillomavirus detection (hrHPV) may be valuable. Using two hrHPV DNA assays, we evaluated the concordance of hrHPV positivity in urine samples in comparis...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05663-7
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medic...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-017-2445-2
更新日期:2017-05-18 00:00:00
abstract:BACKGROUND:The C - reactive protein (CRP) response is often measured in patients with active tuberculosis (TB) yet little is known about its relationship to clinical features in TB, or whether responses differ between ethnic groups or with different Mycobacterium tuberculosis (M.tb) strain types. We report the relation...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1612-1
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly in the myocardium and endocardium, but rarely involving the coronary vessels and valvular structures. Mycobacterium tuberculosis valvular endocarditis is extremely rare, with most reports coming from au...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-231
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:Screening household contacts of active tuberculosis (TB) patients is recommended for TB control. Due to resource constraints this rarely occurs in lower income countries. Demographic and clinical features of index cases may influence the likelihood of onwards TB transmission. It has also been proposed that a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2348-2
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2840-8
更新日期:2017-11-29 00:00:00
abstract::Following publication. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12879-019-3739-3
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes of this activation, however, are incompletely understood. We investigated the activation status of CD4+ T cells specific for chronic herpes viruses and the non-persistent antigen tetanus toxoi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-100
更新日期:2013-02-25 00:00:00
abstract:BACKGROUND:This study aims to investigate the clinical features of invasive community-acquired Staphylococcus aureus (CA-SA) infection in Chinese children and analyze its molecular features. METHODS:Clinical data and invasive CA-SA isolates were prospectively collected. Pediatric risk of mortality (PRISM) score was us...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0582-4
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:This randomized controlled trial aimed to evaluate whether the serum procalcitonin (PCT) level can be utilized to guide the use of antibiotics in the treatment of acute exacerbations of asthma. METHODS:A total of 293 consecutive patients with suspected asthma attacks from February 2005 to July 2010 particip...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-13-596
更新日期:2013-12-17 00:00:00
abstract:BACKGROUND:There have been no reports regarding clinical features and molecular characteristics of childhood methicillin-susceptible Staphylococcus aureus (MSSA) infections in Taiwan. METHODS:We prospectively collected clinical S. aureus isolates from patients aged < 18 years in a university-affiliated hospital in 201...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4033-0
更新日期:2019-05-10 00:00:00
abstract:BACKGROUND:Under-reporting of tuberculosis (TB) cases complicates disease control, hinders contact tracing and alters the accuracy of epidemiological data, including disease burden. The objective of the present study is to evaluate the proportion of unreported TB cases in Spanish healthcare facilities and to identify t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1047-0
更新日期:2015-07-29 00:00:00
abstract::Hepatitis C virus infection (HCV) is one of the most pressing health emergencies in the world with a global prevalence of about 170 million people chronically infected worldwide. In Europe, Italy has the highest HCV prevalence (3 - 4.4%) with peaks of 12.6 - 26% in Southern regions and the major islands. In Italy HCV ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/1471-2334-12-S2-S5
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:With the aim of preparing a more effective, safe and economical vaccine for tuberculosis, inhalable live mycobacterium formulations were evaluated. METHODS:Alginate particles in the size range of 2-4 μm were prepared by encapsulating live Bacille Calmette-Guérin (BCG) and "Mycobacterium indicus pranii" (MIP...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4157-2
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:A reliable prediction of the causative agent of community-acquired pneumonia (CAP) is not possible based on clinical features. Our aim was to test, whether the measurement of the expression of complement receptors or Fcgamma receptors on neutrophils and monocytes would be a useful preliminary test to differe...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-11
更新日期:2006-01-24 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) has emerged as one of the most common causes of epidemic meningoencephalitis worldwide. Most human infections are asymptomatic. However, neuroinvasive disease characterized by meningitis, encephalitis and/or acute flaccid paralysis is associated with significant morbidity and mortality....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1040-7
更新日期:2015-07-31 00:00:00
abstract:BACKGROUND:The purpose of this study was to prospectively investigate the value of real-time ultrasound elastography (RTE) for the diagnosis of liver fibrosis (LF) in patients with chronic hepatitis B (CHB), to correlate the elastography findings with the histologic stage of LF and to compare RTE findings with those fr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4459-4
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Erysipelas is a common skin infection that is prone to recur. Recurrent erysipelas has a severe effect on the quality of life of patients. The present study aimed to investigate the risk factors of recurrent erysipelas in adult Chinese patients. METHODS:A total of 428 Chinese patients with erysipelas who me...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05710-3
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Recently we developed and validated generic quality indicators that define 'appropriate antibiotic use' in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that with appropriate antibiotic use a reduction of 13% of length of hospital stay can be achieved. Our mai...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-015-0867-2
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:Lamivudine inhibits replication of both human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and is commonly used as part of antiretroviral therapy. The main limitation in the use of lamivudine is resistant mutation selection. Most of these mutations affect the YMDD motif of the HBV DNA polymerase....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-4-29
更新日期:2004-08-31 00:00:00