Abstract:
BACKGROUND:A reliable prediction of the causative agent of community-acquired pneumonia (CAP) is not possible based on clinical features. Our aim was to test, whether the measurement of the expression of complement receptors or Fcgamma receptors on neutrophils and monocytes would be a useful preliminary test to differentiate between bacterial and viral pneumonia. METHODS:Sixty-eight patients with CAP were studied prospectively. Thirteen patients had pneumococcal pneumonia; 13 patients, influenza A pneumonia; 5 patients, atypical pneumonia, and 37 patients, aetiologically undefined pneumonia. Leukocyte receptor expression was measured within 2 days of hospital admission. RESULTS:The mean expression of complement receptor 1 (CR1) on neutrophils was significantly higher in the patients with pneumococcal pneumonia than in those with influenza A pneumonia. The mean expression of CR1 was also significantly higher in aetiologically undefined pneumonia than in influenza A pneumonia, but there was no difference between pneumococcal and undefined pneumonia. CONCLUSION:Our results suggest that the expression of CR1 is higher in classical bacterial pneumonia than in viral pneumonia. Determination of the expression of CR1 may be of value as an additional rapid tool in the aetiological diagnosis, bacterial or viral infection, of CAP. These results are preliminary and more research is needed to assess the utility of this new method in the diagnostics of pneumonia.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hohenthal U,Nuutila J,Lilius EM,Laitinen I,Nikoskelainen J,Kotilainen Pdoi
10.1186/1471-2334-6-11keywords:
subject
Has Abstractpub_date
2006-01-24 00:00:00pages
11issn
1471-2334pii
1471-2334-6-11journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS:The medical and electronic records of all patie...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-337
更新日期:2013-07-22 00:00:00
abstract:BACKGROUND:Evidence has existed for decades that higher doses of rifampin may be more effective, but potentially more toxic, than standard doses used in tuberculosis treatment. Whether increased doses of rifampin could safely shorten treatment remains an open question. METHODS/DESIGN:The HIRIF study is a phase II rand...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1790-x
更新日期:2016-08-27 00:00:00
abstract:BACKGROUND:Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The purpose of this study was to assess the association between MC and genital HPV infection in men in a l...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-18
更新日期:2013-01-17 00:00:00
abstract:BACKGROUND:Men who have sex with men (MSM) bear a high burden of syphilis infection. Expanding syphilis testing to improve timely diagnosis and treatment is critical to improve syphilis control. However, syphilis testing rates remain low among MSM, particularly in low- and middle-income countries. We describe the proto...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-020-05188-z
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:The objective of this study was to establish 1) the performance of chest X-ray (CXR) in all suspects of tuberculosis (TB), as well as smear-negative TB suspects and 2) to compare the cost-effectiveness of the routine diagnostic pathway using Ziehl-Neelsen (ZN) sputum microscopy followed by CXR if case of neg...
journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/1471-2334-14-480
更新日期:2014-09-04 00:00:00
abstract:BACKGROUND:Antibiotic resistant strains of Acinetobacter baumannii have been responsible for an increasing number of nosocomial infections including bacteremia and ventilator-associated pneumonia. In this study, we analyzed 38 isolates of A. baumannii obtained from two hospital outbreaks in Los Angeles County for the m...
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pub_type: 杂志文章
doi:10.1186/s12879-016-1526-y
更新日期:2016-05-04 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2300-5
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:A two-stage surgical strategy (debridement-negative pressure therapy (NPT) and flap coverage) with prolonged antimicrobial therapy is usually proposed in pressure ulcer-related pelvic osteomyelitis but has not been widely evaluated. METHODS:Adult patients with pressure ulcer-related pelvic osteomyelitis tre...
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pub_type: 杂志文章
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更新日期:2018-04-10 00:00:00
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更新日期:2019-06-17 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:To determine the prevalence of enteric infections in Aboriginal children aged 0-2 years using conventional and molecular diagnostic techniques and to explore associations between the presence of pathogens and child growth. METHODS:Cross-sectional analysis of Aboriginal children (n = 62) residing in a remote...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05685-1
更新日期:2021-01-06 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2018-12-10 00:00:00
abstract:BACKGROUND:In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all doubl...
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pub_type: 杂志文章
doi:10.1186/s12879-015-0769-3
更新日期:2015-02-03 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-019-4385-5
更新日期:2019-08-20 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-018-3272-9
更新日期:2018-08-30 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-015-1170-y
更新日期:2015-10-31 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-019-4293-8
更新日期:2019-07-22 00:00:00
abstract:BACKGROUND:Context-specific factors influence adherence to antiretroviral therapy (ART) among pregnant women living with HIV. Gaps exist in the understanding of the reasons for the variable outcomes of the prevention of mother-to-child transmission (PMTCT) programme at the health facility level in South Africa. This st...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
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更新日期:2018-04-13 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-020-05212-2
更新日期:2020-07-16 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-22 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Corynebacterium striatum is a member of the non-diphtherial corynebacteria, which are ubiquitous in nature and generally colonize the skin and mucous membranes of humans. Rarely, it causes infective endocarditis (IE). We report a case of rare left atrial bacterial vegetative mass due to C. striatum masquerad...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2468-8
更新日期:2017-05-26 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
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更新日期:2012-09-25 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2017-09-20 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-112
更新日期:2005-12-12 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2793-y
更新日期:2017-10-11 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-286
更新日期:2012-11-02 00:00:00