ICARES: a real-time automated detection tool for clusters of infectious diseases in the Netherlands.

Abstract:

BACKGROUND:Clusters of infectious diseases are frequently detected late. Real-time, detailed information about an evolving cluster and possible associated conditions is essential for local policy makers, travelers planning to visit the area, and the local population. This is currently illustrated in the Zika virus outbreak. METHODS:In the Netherlands, ICARES (Integrated Crisis Alert and Response System) has been developed and tested on three syndromes as an automated, real-time tool for early detection of clusters of infectious diseases. From local general practices, General Practice Out-of-Hours services and a hospital, the numbers of routinely used syndrome codes for three piloted tracts i.e., respiratory tract infection, hepatitis and encephalitis/meningitis, are sent on a daily basis to a central unit of infectious disease control. Historic data combined with information about patients' syndromes, age cohort, gender and postal code area have been used to detect clusters of cases. RESULTS:During the first 2 years, two out of eight alerts appeared to be a real cluster. The first was part of the seasonal increase in Enterovirus encephalitis and the second was a remarkably long lasting influenza season with high peak incidence. CONCLUSIONS:This tool is believed to be the first flexible automated, real-time cluster detection system for infectious diseases, based on physician information from both general practitioners and hospitals. ICARES is able to detect and follow small regional clusters in real time and can handle any diseases entity that is regularly registered by first line physicians. Its value will be improved when more health care institutions agree to link up with ICARES thus improving further the signal-to-noise ratio.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Groeneveld GH,Dalhuijsen A,Kara-Zaïtri C,Hamilton B,de Waal MW,van Dissel JT,van Steenbergen JE

doi

10.1186/s12879-017-2300-5

subject

Has Abstract

pub_date

2017-03-09 00:00:00

pages

201

issue

1

issn

1471-2334

pii

10.1186/s12879-017-2300-5

journal_volume

17

pub_type

杂志文章
  • Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Johannesburg, South Africa, 2007-2014.

    abstract:BACKGROUND:Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determining regions of M. genitalium in Johannesburg, South Africa, and ascertained their association wit...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3797-6

    authors: Muller EE,Mahlangu MP,Lewis DA,Kularatne RS

    更新日期:2019-02-13 00:00:00

  • Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.

    abstract:BACKGROUND:It is estimated that Lao People's Democratic Republic (Lao PDR) ranks fifth among the seven countries most affected by TB in the WHO Western Pacific Region. However, because of late implementation of mycobacterial culture, no study on resistance to anti-TB drugs had been performed yet. The objective of this ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-13-275

    authors: Iem V,Somphavong S,Buisson Y,Steenkeste N,Breysse F,Chomarat M,Sylavanh P,Nanthavong P,Rajoharison A,Berland JL,Paboriboune P

    更新日期:2013-06-19 00:00:00

  • Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients.

    abstract:BACKGROUND:Statin use is associated with a modest increase in the incidence of type 2 diabetes mellitus (DM) among the general population. However, HIV-infected patients have a higher risk of developing DM, and it is unclear whether statins have a diabetogenic effect in these patients. Therefore, we investigated the as...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2099-5

    authors: Spagnuolo V,Galli L,Poli A,Salpietro S,Gianotti N,Piatti P,Cossarini F,Vinci C,Carini E,Lazzarin A,Castagna A

    更新日期:2017-01-07 00:00:00

  • Completeness of tuberculosis case notifications in Germany in 2013-2017: first results of an inventory study.

    abstract:BACKGROUND:Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013-2017. METHODS:Acquisition of two pseudonymized case-based data sources (national TB notification data a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05467-9

    authors: Domaszewska T,Karo B,Preuss U,Kollan C,Reuss A,Blank HP,Brodhun B,Hauer B,Altmann D,Fiebig L,Haas W,Perumal N

    更新日期:2020-10-17 00:00:00

  • An economic analysis of premarriage prevention of hepatitis B transmission in Iran.

    abstract:BACKGROUND:To assess the economic aspects of HBV (hepatitis B virus) transmission prevention for premarriage individuals in a country with cultural backgrounds like Iran and intermediate endemicity of HBV infection. METHODS:A cost-effectiveness analysis model was used from the health care system and society perspectiv...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-4-31

    authors: Adibi P,Rezailashkajani M,Roshandel D,Behrouz N,Ansari S,Somi MH,Shahraz S,Zali MR

    更新日期:2004-09-04 00:00:00

  • Evaluation of HIV testing algorithms in Ethiopia: the role of the tie-breaker algorithm and weakly reacting test lines in contributing to a high rate of false positive HIV diagnoses.

    abstract:BACKGROUND:In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all doubl...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0769-3

    authors: Shanks L,Siddiqui MR,Kliescikova J,Pearce N,Ariti C,Muluneh L,Pirou E,Ritmeijer K,Masiga J,Abebe A

    更新日期:2015-02-03 00:00:00

  • Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report.

    abstract:BACKGROUND:Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-330

    authors: Schoffelen T,den Broeder AA,Nabuurs-Franssen M,van Deuren M,Sprong T

    更新日期:2014-06-15 00:00:00

  • Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients.

    abstract:BACKGROUND:Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with inva...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-11-60

    authors: Pemán J,Zaragoza R,Quindós G,Alkorta M,Cuétara MS,Camarena JJ,Ramírez P,Giménez MJ,Martín-Mazuelos E,Linares-Sicilia MJ,Pontón J,study group Candida albicans Germ Tube Antibody Detection in Critically Ill Patients.

    更新日期:2011-03-09 00:00:00

  • Epidemiological and clinical characteristics of healthcare-associated infection in elderly patients in a large Chinese tertiary hospital: a 3-year surveillance study.

    abstract:BACKGROUND:We analyzed the results of a 3-year surveillance study on the epidemiological and clinical characteristics of healthcare associated-infections (HAIs) in elderly inpatients in a large tertiary hospital in China. METHODS:Real-time surveillance was performed from January 1, 2015 to December 31, 2017. All HAIs ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-4840-3

    authors: Zhao X,Wang L,Wei N,Zhang J,Ma W,Zhao H,Han X

    更新日期:2020-02-10 00:00:00

  • Fasting plasma glucose is an independent predictor for severity of H1N1 pneumonia.

    abstract:BACKGROUND:The pandemic influenza A (H1N1) virus emerged during 2009 and has spread worldwide. This virus can cause injuries to the lungs, liver, and heart. However, data regarding whether this influenza virus can affect pancreatic islets are limited. We investigated the effects of influenza A (H1N1) pneumonia on fasti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-104

    authors: Wang W,Chen H,Li Q,Qiu B,Wang J,Sun X,Xiang Y,Zhang J

    更新日期:2011-04-21 00:00:00

  • Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia.

    abstract:BACKGROUND:This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children in Ethiopia. METHODS:We model the mosquito abundance and time to malaria data jointly in a Bayesian framework. RE...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2496-4

    authors: Belay DB,Kifle YG,Goshu AT,Gran JM,Yewhalaw D,Duchateau L,Frigessi A

    更新日期:2017-06-12 00:00:00

  • Prevalence of Chlamydia trachomatis infection in women, heterosexual men and MSM visiting HIV counselling institutions in North Rhine-Westphalia, Germany - should Chlamydia testing be scaled up?

    abstract:BACKGROUND:Patients asking for a free anonymous HIV test may have contracted other sexually transmitted infections (STIs) such as Chlamydia trachomatis, yet Chlamydia prevalence in that population is unknown. This study aimed to assess the prevalence and factors associated with Chlamydia infection in patients seeking H...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1915-2

    authors: Lallemand A,Bremer V,Jansen K,Nielsen S,Münstermann D,Lucht A,Tiemann C

    更新日期:2016-10-26 00:00:00

  • Human papillomavirus genotypes and P16INK4A expression in squamous penile carcinoma in Mexican patients.

    abstract:BACKGROUND:Approximately 50% of cases of penile carcinoma (PeCa), a rare neoplasm worldwide, are associated with human papillomavirus (HPV). However, the detection of HPV-DNA is not sufficient to consider it the etiological factor in the development of this type of cancer. Currently, the overexpression of P16INK4A is u...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4696-6

    authors: Martínez-Bailón C,Mantilla-Morales A,Méndez-Matías G,Alvarado-Cabrero I,Maldonado-Rodríguez R,Quintero-Becerra J,Arias-Flores R,Piña-Sánchez P

    更新日期:2019-12-19 00:00:00

  • Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes.

    abstract:BACKGROUND:Drug susceptibility testing (DST) remains an important concern for implementing treatment of MDR tuberculosis patients. Implementation of molecular tests for drug resistance identification would facilitate DST particularly in developing countries where culturing is difficult to perform. We have characterized...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-255

    authors: Surcouf C,Heng S,Pierre-Audigier C,Cadet-Daniel V,Namouchi A,Murray A,Gicquel B,Guillard B

    更新日期:2011-09-28 00:00:00

  • The incidence, risk factors and outcomes of early bloodstream infection in patients with malignant hematologic disease after unrelated cord blood transplantation: a retrospective study.

    abstract:BACKGROUND:Bloodstream infection (BSI) is one of the major causes of morbidity and mortality for patients undergoing hematopoietic stem cell transplantation (HSCT). The unrelated cord blood transplantation (UCBT) can provided opportunities for patients without suitable donors for bone marrow transplantation (BMT) and p...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3575-x

    authors: Ge J,Yang T,Zhang L,Zhang X,Zhu X,Tang B,Wan X,Tong J,Song K,Yao W,Sun G,Sun Z,Liu H

    更新日期:2018-12-13 00:00:00

  • Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.

    abstract:BACKGROUND:The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. METHODS:We performed a prospective multicentre study in inmates from 25 Spanis...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-015-1102-x

    authors: Marco A,Antón JJ,Trujols J,Saíz de la Hoya P,de Juan J,Faraco I,Caylà JA,Perseo Group.

    更新日期:2015-08-19 00:00:00

  • Comparison of two commercial broad-range PCR and sequencing assays for identification of bacteria in culture-negative clinical samples.

    abstract:BACKGROUND:Culturing has long been the gold standard for detecting aetiologic agents in bacterial infections. In some cases, however, culturing fails to detect the infection. To further investigate culture-negative samples, amplification and subsequent sequencing of the 16S rRNA gene is often applied. The aim of the pr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2333-9

    authors: Stavnsbjerg C,Frimodt-Møller N,Moser C,Bjarnsholt T

    更新日期:2017-03-27 00:00:00

  • Modelling the force of infection for hepatitis B and hepatitis C in injecting drug users in England and Wales.

    abstract:BACKGROUND:Injecting drug use is a key risk factor, for several infections of public health importance, especially hepatitis B (HBV) and hepatitis C (HCV). In England and Wales, where less than 1% of the population are likely to be injecting drug users (IDUs), approximately 38% of laboratory reports of HBV, and 95% of ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-6-93

    authors: Sutton AJ,Gay NJ,Edmunds WJ,Hope VD,Gill ON,Hickman M

    更新日期:2006-06-08 00:00:00

  • Black race as a predictor of poor health outcomes among a national cohort of HIV/AIDS patients admitted to US hospitals: a cohort study.

    abstract:BACKGROUND:In general, the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) population has begun to experience the benefits of highly active antiretroviral therapy (HAART); unfortunately, these benefits have not extended equally to Blacks in the United States, possibly due to differences in pa...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-127

    authors: Oramasionwu CU,Hunter JM,Skinner J,Ryan L,Lawson KA,Brown CM,Makos BR,Frei CR

    更新日期:2009-08-11 00:00:00

  • Emergence of human West Nile Virus infection in Sri Lanka.

    abstract:BACKGROUND:West Nile virus (WNV) has emerged as one of the most common causes of epidemic meningoencephalitis worldwide. Most human infections are asymptomatic. However, neuroinvasive disease characterized by meningitis, encephalitis and/or acute flaccid paralysis is associated with significant morbidity and mortality....

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1040-7

    authors: Lohitharajah J,Malavige GN,Chua AJ,Ng ML,Arambepola C,Chang T

    更新日期:2015-07-31 00:00:00

  • Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations.

    abstract:BACKGROUND:Self-reported antiretroviral therapy (ART) adherence measures that are associated with plasma viral load (VL) are valuable to clinicians and researchers, but are rarely examined among groups vulnerable to dropping out of care. One-seventh of all those living with HIV pass through incarceration annually and c...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4443-z

    authors: Cunningham WE,Nance RM,Golin CE,Flynn P,Knight K,Beckwith CG,Kuo I,Spaulding A,Taxman FS,Altice F,Delaney JA,Crane HM,Springer SA

    更新日期:2019-10-29 00:00:00

  • A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population.

    abstract:BACKGROUND:Hepatitis B virus (HBV) infection is a significant public health problem that may lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Approximately 30% of the world's population has been infected with HBV and approximately 350 million (5-6%) are persistent carriers. More than 120 mi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-8-1

    authors: Zeng Z,Guan L,An P,Sun S,O'Brien SJ,Winkler CA,HBV study consortium.

    更新日期:2008-01-02 00:00:00

  • Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection.

    abstract:BACKGROUND:Lyme disease, a bacterial infection with the tick-borne spirochete Borrelia burgdorferi, can cause early and late manifestations. The category of probable Lyme disease was recently added to the CDC surveillance case definition to describe patients with serologic evidence of exposure and physician-diagnosed d...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-173

    authors: Aucott JN,Seifter A,Rebman AW

    更新日期:2012-08-01 00:00:00

  • Point-of-care p24 antigen detection for early infant diagnosis of HIV infection: cross-sectional and longitudinal studies in Zambia.

    abstract:BACKGROUND:Early infant diagnosis of HIV infection is challenging in sub-Saharan Africa, particularly in rural areas, leading to delays in diagnosis and treatment. Use of a point-of-care test would overcome many challenges. This study evaluated the validity of a novel point-of-care p24 antigen detection test (LYNX) in ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-021-05808-2

    authors: Sutcliffe CG,Mutanga J,Moyo N,Agarwal AK,Schue JL,Hamahuwa M,Palamountain KM,Fisher MJ,Elghanian R,Thuma PE,Moss WJ

    更新日期:2021-01-26 00:00:00

  • Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry.

    abstract:BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis is not well characterised. We have used baseline data of the Investigation o...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-6-2

    authors: Mayosi BM,Wiysonge CS,Ntsekhe M,Volmink JA,Gumedze F,Maartens G,Aje A,Thomas BM,Thomas KM,Awotedu AA,Thembela B,Mntla P,Maritz F,Blackett KN,Nkouonlack DC,Burch VC,Rebe K,Parish A,Sliwa K,Vezi BZ,Alam N,Brown BG

    更新日期:2006-01-06 00:00:00

  • Treatment of isoniazid-resistant pulmonary tuberculosis.

    abstract:BACKGROUND:Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-resistant tuberculosis (TB). METHODS:We evaluated retrospectively the treatmen...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-8-6

    authors: Kim YH,Suh GY,Chung MP,Kim H,Kwon OJ,Lim SY,Lim SY,Koh WJ

    更新日期:2008-01-23 00:00:00

  • Renal impairment in a rural African antiretroviral programme.

    abstract:BACKGROUND:There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofov...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-143

    authors: Franey C,Knott D,Barnighausen T,Dedicoat M,Adam A,Lessells RJ,Newell ML,Cooke GS

    更新日期:2009-08-28 00:00:00

  • Norovirus gastroenteritis general outbreak associated with raw shellfish consumption in south Italy.

    abstract:BACKGROUND:Despite Noroviruses (NV, previously "Norwalk-like viruses") being a leading cause of acute gastroenteritis outbreaks, the impact of NV infection is at present unknown and little information is available about strains circulating in Italy. In April 2002 an outbreak of gastroenteritis occurred in the province ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-4-37

    authors: Prato R,Lopalco PL,Chironna M,Barbuti G,Germinario C,Quarto M

    更新日期:2004-09-21 00:00:00

  • Leprosy & gangrene: a rare association; role of anti phospholipid antibodies.

    abstract:BACKGROUND:Leprosy still remains an important public health problem for many parts of the world. An association of gangrene with leprosy is a rare one & can have a number of causative mechanisms. We present a case with Leprosy & gangrene with positive anti phopholipid antibody titers. CASE PRESENTATION:A 50-year-old n...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-5-74

    authors: Akerkar SM,Bichile LS

    更新日期:2005-09-21 00:00:00

  • The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study.

    abstract:BACKGROUND:Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS:This mult...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-017-2858-y

    authors: Katsurada N,Suzuki M,Aoshima M,Yaegashi M,Ishifuji T,Asoh N,Hamashige N,Abe M,Ariyoshi K,Morimoto K,Adult Pneumonia Study Group-Japan.

    更新日期:2017-12-06 00:00:00