当前位置： SCI文献检索 > BMC INFECTIOUS DISEASES期刊下所有文献 > Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.

Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.

Abstract：

BACKGROUND:The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. METHODS:We performed a prospective multicentre study in inmates from 25 Spanish prisons who had been treated with pegylated interferon alfa-2a plus ribavirin in 2011. PD diagnosis was based on the Personality Diagnostic Questionnaire-4+. We calculated adjusted Odds Ratios (AOR) and 95 % confidence intervals (95 % CI) using logistic regression. RESULTS:The sample included 236 patients (mean age: 40.3 years, 92.8 % male, 79.2 % intravenous drug users, and 26.3 % HIV-coinfected). The prevalence of PD was 72.5 %. 32.2 % of patients discontinued treatment; this percentage was higher in patients with HCV genotypes 1/4 (AOR = 3.55; CI:1.76-7.18) and those without PD (AOR = 2.51; 1.23-5.11). Treatment discontinuation was mainly for penitentiary reasons (40.3 %): release or transfer between prisons. The rate of sustained viral response (SVR) was 52.1 % by ITT and 76.9 % by observed treatment (OT). SVR was higher among patients with genotype 2 or 3, and those with low baseline HCV-RNA. We did not observe any differences between individuals with and without PD in term of SVR, HCV genotype or HIV infection. CONCLUSIONS:Our results support the safety and clinical effectiveness of the treatment of chronic HCV infection in correctional facilities, both in prisoners with PD and those without. Our data support non-discrimination between patients with and without PD when offering treatment for HCV infection to prison inmates. TRIAL REGISTRATION:Trial registration number (TRN) NCT01900886 . Date of registration: July 8, 2013.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Marco A,Antón JJ,Trujols J,Saíz de la Hoya P,de Juan J,Faraco I,Caylà JA,Perseo Group.

doi

10.1186/s12879-015-1102-x

subject

Has Abstract

pub_date

2015-08-19 00:00:00

pages

355

issn

1471-2334

pii

10.1186/s12879-015-1102-x

journal_volume

15

pub_type

杂志文章,多中心研究

相关文献

BMC INFECTIOUS DISEASES文献大全
  • Seroprevalence, spatial dispersion and factors associated with flavivirus and chikungunha infection in a risk area: a population-based seroprevalence study in Brazil.

    abstract：BACKGROUND:The State of Ceará, in Northeastern Brazil, suffers from a triple burden of arboviruses (dengue, Zika and chikungunya). We measured the seroprevalence of chikungunya, dengue and Zika and its associated factors in the population of Juazeiro do Norte, Southern Ceará State, Brazil. METHODS:A cross-sectional st...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-020-05611-5

    authors： Barreto FKA,Alencar CH,Araújo FMC,Oliveira RMAB,Cavalcante JW,Lemos DRQ,Farias LABG,Boriz ILF,Medeiros LQ,Melo MNP,Miyajima F,Siqueira AM,Freitas ARR,Cavalcanti LPG

    更新日期：2020-11-24 00:00:00

  • Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage.

    abstract：BACKGROUND:To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS:From September 2014 to November 201...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-020-04979-8

    authors： Hsu YY,Wu D,Hung CC,Huang SS,Yuan FH,Lee MH,Huang CT,Shie SS,Huang PY,Yang CC,Cheng CW,Leu HS,Wu TS,Huang YC

    更新日期：2020-03-30 00:00:00

  • Procalcitonin (PCT) and C-reactive protein (CRP) as severe systemic infection markers in febrile neutropenic adults.

    abstract：BACKGROUND:Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile. METHODS:52 adult patients were enrolled in the study. B...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-7-137

    authors： Massaro KS,Costa SF,Leone C,Chamone DA

    更新日期：2007-11-22 00:00:00

  • An evaluation of a recombinant multiepitope based antigen for detection of Toxoplasma gondii specific antibodies.

    abstract：BACKGROUND:The inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates the need for acquirement of reliable and standard diagnostic reagents. Recently, epitope-based antigens have emerged as an alternative diagnostic marker for the achievemen...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-017-2920-9

    authors： Hajissa K,Zakaria R,Suppian R,Mohamed Z

    更新日期：2017-12-29 00:00:00

  • Clinical and microbiological characteristics of purulent and non-purulent cellulitis in hospitalized Taiwanese adults in the era of community-associated methicillin-resistant Staphylococcus aureus.

    abstract：BACKGROUND:The risk factors, microbial etiology, differentiation, and clinical features of purulent and non-purulent cellulitis are not well defined in Taiwan. METHODS:We conducted a retrospective cohort study of hospitalized adults with cellulitis in Taiwan in 2013. The demographic characteristics, underlying disease...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-1064-z

    authors： Lee CY,Tsai HC,Kunin CM,Lee SS,Chen YS

    更新日期：2015-08-05 00:00:00

  • Clinically mild encephalitis/encephalopathy with a reversible splenial lesion caused by methicillin-sensitive Staphylococcus aureus bacteremia with toxic shock syndrome: a case report.

    abstract：BACKGROUND:Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a mild encephalopathy caused by various pathological processes, but encephalopathy due to bacteria is rare. CASE PRESENTATION:We report the case of a 45-year-old Japanese woman who on receiving chemotherapy for advanced ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1516-0

    authors： Kosami K,Kenzaka T,Sagara Y,Minami K,Matsumura M

    更新日期：2016-04-18 00:00:00

  • Prevalence, clinical and economic burden of mucormycosis-related hospitalizations in the United States: a retrospective study.

    abstract：BACKGROUND:Mucormycosis is a rare but devastating fungal infection primarily affecting immunocompromised patients such as those with hematological malignancy, bone marrow and solid organ transplantation, and patients with diabetes, and, even more rarely, immunocompetent patients. The objective of this study was to asse...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-2023-z

    authors： Kontoyiannis DP,Yang H,Song J,Kelkar SS,Yang X,Azie N,Harrington R,Fan A,Lee E,Spalding JR

    更新日期：2016-12-01 00:00:00

  • Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus.

    abstract：BACKGROUND:Neonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated with a focus of infection. This distinction is not well characterized. METHODS:All patients with neo...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-017-2574-7

    authors： Wu IH,Tsai MH,Lai MY,Hsu LF,Chiang MC,Lien R,Fu RH,Huang HR,Chu SM,Hsu JF

    更新日期：2017-07-03 00:00:00

  • Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities.

    abstract：BACKGROUND:Antimicrobial resistance (AMR) is a major challenge for global health care. Pharmacists play a key role in the health care setting to help support the quality use of medicines. The education, training, and experiences of pharmacy students have the potential to impact on patterns of antibiotic use in communit...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-018-3107-8

    authors： Sakeena MHF,Bennett AA,Jamshed S,Mohamed F,Herath DR,Gawarammana I,McLachlan AJ

    更新日期：2018-05-08 00:00:00

  • Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars.

    abstract：BACKGROUND:In Germany, 17% of the general human population have antibodies to hepatitis E virus (HEV) (recomLine HEV-IgG/IgM immunoassay [Mikrogen GmbH]). Wild boars represent an animal reservoir for HEV genotype 3, which is the common genotype in Germany. We estimated the seroprevalence among hunters with contact to w...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-1199-y

    authors： Schielke A,Ibrahim V,Czogiel I,Faber M,Schrader C,Dremsek P,Ulrich RG,Johne R

    更新日期：2015-10-22 00:00:00

  • Incidence, risk factors, and outcomes of Fusobacterium species bacteremia.

    abstract：BACKGROUND:Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical o...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-13-264

    authors： Afra K,Laupland K,Leal J,Lloyd T,Gregson D

    更新日期：2013-06-05 00:00:00

  • Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count.

    abstract：BACKGROUND:HIV infection has been modifying both the epidemiology and outcome of parasitic infections. Hence, this study was undertaken to determine the prevalence of intestinal parasitic infection among people with and without HIV infection and its association with diarrhea and CD4 T-cell count. METHODS:A cross-secti...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-9-155

    authors： Assefa S,Erko B,Medhin G,Assefa Z,Shimelis T

    更新日期：2009-09-18 00:00:00

  • Safety and efficacy of the combination simeprevir-sofosbuvir in HCV genotype 1- and 4-mono-infected patients from the French ANRS CO22 hepather cohort.

    abstract：BACKGROUND:Although real-life results of sofosbuvir/simeprevir have been extensively reported from the United States, data from other geographical areas are limited. In the French observational cohort, ANRS CO22 HEPATHER, 9432 patients were given the new oral antivirals from December 2013 to June 30, 2018. We report th...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-019-3923-5

    authors： Laurain A,Metivier S,Haour G,Larrey D,Dorival C,Hezode C,Zoulim F,Marcellin P,Bourliere M,Zarski JP,Thabut D,Alric L,Ganne-Carrie N,Cales P,Bronowicki JP,Riachi G,Geist C,Causse X,Abergel A,Chazouilleres O,Mathuri

    更新日期：2019-04-02 00:00:00

  • Detection of viable but non-culturable Pseudomonas aeruginosa in cystic fibrosis by qPCR: a validation study.

    abstract：BACKGROUND:Routine culture-based diagnosis of Pseudomonas aeruginosa lung infection in Cystic Fibrosis (CF) patients can be hampered by the phenotypic variability of the microorganism, including its transition to a Viable But Non-Culturable (VBNC) state. The aim of this study was to validate an ecfX-targeting qPCR prot...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-018-3612-9

    authors： Mangiaterra G,Amiri M,Di Cesare A,Pasquaroli S,Manso E,Cirilli N,Citterio B,Vignaroli C,Biavasco F

    更新日期：2018-12-27 00:00:00

  • Recurrent severe invasive pneumococcal disease in an adult with previously unknown hyposplenia.

    abstract：BACKGROUND:The risk of life-threatening and invasive infections with encapsulated bacteria is increased in patients with hyposplenia or asplenia. We report a case of recurrent invasive pneumococcal meningitis in a woman with previous unknown hyposplenia. She was vaccinated after the first episode of meningitis and deve...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-0883-2

    authors： Ballegaard VC,Schejbel L,Hoffmann S,Kantsø B,Fischer CP

    更新日期：2015-04-02 00:00:00

  • Immunogenicity of the CYD tetravalent dengue vaccine using an accelerated schedule: randomised phase II study in US adults.

    abstract：BACKGROUND:The live attenuated tetravalent dengue vaccine (CYD-TDV) is licensed using a 0-, 6- and 12-month schedule in dengue-endemic areas. An effective shorter schedule may provide more rapid, optimal protection of targeted populations during vaccine campaigns in dengue-endemic countries. We compared immune response...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12879-018-3389-x

    authors： Kirstein J,Douglas W,Thakur M,Boaz M,Papa T,Skipetrova A,Plennevaux E

    更新日期：2018-09-21 00:00:00

  • Diagnostic and treatment delay among pulmonary tuberculosis patients in Ethiopia: a cross sectional study.

    abstract：BACKGROUND:Delayed diagnosis and treatment of tuberculosis (TB) results in severe disease and a higher mortality. It also leads to an increased period of infectivity in the community. The objective of this study was to determine the length of delays, and analyze the factors affecting the delay from onset of symptoms of...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-5-112

    authors： Yimer S,Bjune G,Alene G

    更新日期：2005-12-12 00:00:00

  • Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

    abstract：BACKGROUND:Large scale administration of the anthelminthic drug praziquantel (PZQ) to at-risk populations is the cornerstone of schistosomiasis control, although persisting high prevalence of infections in some areas and growing concerns of PZQ resistance have revealed the limitations of this strategy. Most studies ass...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12879-018-3554-2

    authors： Hoekstra PT,Casacuberta Partal M,Amoah AS,van Lieshout L,Corstjens PLAM,Tsonaka S,Assaré RK,Silué KD,Meité A,N'Goran EK,N'Gbesso YK,Roestenberg M,Knopp S,Utzinger J,Coulibaly JT,van Dam GJ

    更新日期：2018-12-14 00:00:00

  • Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.

    abstract：BACKGROUND:The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART. The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. ...

    journal_title：BMC infectious diseases

    pub_type： 临床试验,杂志文章

    doi：10.1186/1471-2334-2-17

    authors： Bruno R,Sacchi P,Puoti M,Ciappina V,Zocchetti C,Brunetti E,Maffezzini E,Capelli A,Patruno SF,Malfitano A,Filice G

    更新日期：2002-08-28 00:00:00

  • Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B.

    abstract：BACKGROUND:Complete clearance of intracellular viruses depends on effector cells of innate and adaptive immune systems. This study aimed to identify the relationships among antiviral cytokines produced by natural killer (NK) and T cells and clinical-virological characteristics in untreated chronic hepatitis B (CHB) pat...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-020-05233-x

    authors： Gu Y,Lian Y,Zheng Q,Huang Z,Gu L,Bi Y,Li J,Huang Y,Wu Y,Chen L,Huang Y

    更新日期：2020-07-14 00:00:00

  • Infection characteristics and treatment of Staphylococcus aureus bacteraemia at a tertiary children's hospital.

    abstract：BACKGROUND:Staphylococcus aureus bacteraemia (SAB) causes considerable morbidity and mortality in children. Despite this, its epidemiology and risk factors are poorly understood, with minimal paediatric clinical trial data available to guide clinicians in management. We conducted a pilot study to characterise SAB and v...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-018-3312-5

    authors： Munro APS,Blyth CC,Campbell AJ,Bowen AC

    更新日期：2018-08-10 00:00:00

  • Pneumonia and poverty: a prospective population-based study among children in Brazil.

    abstract：BACKGROUND:Children in developing country suffer the highest burden of pneumonia. However, few studies have evaluated associations between poverty and pneumonia. METHODS:A prospective population-based study on pneumonia was carried out as part of the Latin America Epidemiological Assessment of Pneumococcus (LEAP study...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-11-180

    authors： Thörn LK,Minamisava R,Nouer SS,Ribeiro LH,Andrade AL

    更新日期：2011-06-22 00:00:00

  • Dengue type 4 in Rio de Janeiro, Brazil: case characterization following its introduction in an endemic region.

    abstract：BACKGROUND:Due to the populations' susceptibility, DENV-4 introduction in 2010 led to the occurrence of explosive epidemics in the following years in Brazil. In 2011, DENV-4 was identified in Rio de Janeiro (RJ) and it was prevalent in 2012 and 2013. Here, we aimed to characterize clinical, epidemiological and laborato...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-017-2488-4

    authors： Heringer M,Souza TMA,Lima MDRQ,Nunes PCG,Faria NRDC,de Bruycker-Nogueira F,Chouin-Carneiro T,Nogueira RMR,Dos Santos FB

    更新日期：2017-06-09 00:00:00

  • Variations in DEPDC5 gene and its association with chronic hepatitis C virus infection in Saudi Arabia.

    abstract：BACKGROUND:Variations at DEPDC5 gene have been recently reported as genetic markers associated with hepatocellular carcinoma (HCC) progression in chronic HCV-infected patients. This study was conducted to assess the association of DEPDC5 variants with advanced liver cirrhosis and HCC development among chronic HCV-infec...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-014-0632-y

    authors： Al-Anazi MR,Matou-Nasri S,Abdo AA,Sanai FM,Khan MQ,Albenmousa A,Al-Ashgar HI,Khalaf NZ,Al-Ahdal MN,Al-Qahtani AA

    更新日期：2014-12-31 00:00:00

  • Fatigue during treatment for hepatitis C virus: results of self-reported fatigue severity in two Phase IIb studies of simeprevir treatment in patients with hepatitis C virus genotype 1 infection.

    abstract：BACKGROUND:Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV. This study evaluated the impact of adding the oral HCV NS3/4A protease inhibitor simeprevir to PR on patient-reported fatigue and health status among patients w...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2334-14-465

    authors： Scott J,Rosa K,Fu M,Cerri K,Peeters M,Beumont M,Zeuzem S,Evon DM,Gilles L

    更新日期：2014-08-26 00:00:00

  • Temporal trends in hepatitis B and C infection in family blood donors from interior Sindh, Pakistan.

    abstract：BACKGROUND:Hepatitis B (HBV) and C (HCV) infections are a serious global and national public health problem. Earlier studies have reported increasing rates of hepatitis infection in Pakistan, particularly in rural areas. Pakistan has no active surveillance program to monitor trends of these infections. The objective of...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/1471-2334-8-43

    authors： Mujeeb SA,Pearce MS

    更新日期：2008-04-10 00:00:00

  • Good continuum of HIV care in Belgium despite weaknesses in retention and linkage to care among migrants.

    abstract：BACKGROUND:The Belgian HIV epidemic is largely concentrated among men who have sex with men and Sub-Saharan Africans. We studied the continuum of HIV care of those diagnosed with HIV living in Belgium and its associated factors. METHODS:Data on new HIV diagnoses 2007-2010 and HIV-infected patients in care in 2010-2011...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-015-1230-3

    authors： Van Beckhoven D,Florence E,Ruelle J,Deblonde J,Verhofstede C,Callens S,Vancutsem E,Lacor P,Demeester R,Goffard JC,Sasse A,BREACH Belgian Research on AIDS and HIV Consortium.

    更新日期：2015-11-03 00:00:00

  • Comparison of loop-mediated isothermal amplification assay and smear microscopy with culture for the diagnostic accuracy of tuberculosis.

    abstract：BACKGROUND:Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of death from infectious diseases worldwide. Sputum smear microscopy remains the most widely available pulmonary TB diagnostic tool particularly in resource limited settings. A highly sensitive diagnostic with minimal infrast...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-2140-8

    authors： Gelaw B,Shiferaw Y,Alemayehu M,Bashaw AA

    更新日期：2017-01-17 00:00:00

  • Tuberculosis infection control knowledge and attitudes among health workers in Uganda: a cross-sectional study.

    abstract：BACKGROUND:The World Health Organization recommends TB infection control (TBIC) in health care facilities. In 2008, the Ministry of Health Uganda initiated efforts to implement TBIC by training of health care workers (HCWs). This study was carried out to assess knowledge and attitudes towards TBIC among HCWs. METHODS:...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1740-7

    authors： Buregyeya E,Kasasa S,Mitchell EM

    更新日期：2016-08-15 00:00:00

  • Management of ventilator-associated pneumonia in intensive care units: a mixed methods study assessing barriers and facilitators to guideline adherence.

    abstract：BACKGROUND:Guidelines from the Infectious Diseases Society of America/The American Thoracic Society (IDSA/ATS) provide recommendations for diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the mere presence of guidelines is rarely sufficient to promote widespread adoption and uptake. Using the ...

    journal_title：BMC infectious diseases

    pub_type： 杂志文章

    doi：10.1186/s12879-016-1665-1

    authors： Safdar N,Musuuza JS,Xie A,Hundt AS,Hall M,Wood K,Carayon P

    更新日期：2016-07-22 00:00:00