Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C.


BACKGROUND:The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART. The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS:We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA <50 copies/ml in all patients; HCV-RNA 28, 3 x 106 copies/ml. RESULTS:At 48 weeks, 10 patients (20%) achieved a biochemical and virological response according to an intention to treat analysis.Twenty four patients (48%) underwent a drop-out mainly by side effects related to overlapping toxicity of interferon and antiretroviral therapy. All the patients, who responded to the treatment, showed a fast relapse one month after the end of treatment. CONCLUSION:Although our results demonstrated a very poor outcome and a bad tolerance to interferon monotherapy, this approach should not be dropped out, mainly in patients at high risk for side effects and in those with cirrhosis who do not tolerate or are at increased risk for the use of ribavirin.


BMC Infect Dis


BMC infectious diseases


Bruno R,Sacchi P,Puoti M,Ciappina V,Zocchetti C,Brunetti E,Maffezzini E,Capelli A,Patruno SF,Malfitano A,Filice G





Has Abstract


2002-08-28 00:00:00








  • Association of Escherichia coli O157:H7 tir polymorphisms with human infection.

    abstract:BACKGROUND:Emerging molecular, animal model and epidemiologic evidence suggests that Shiga-toxigenic Escherichia coli O157:H7 (STEC O157) isolates vary in their capacity to cause human infection and disease. The translocated intimin receptor (tir) and intimin (eae) are virulence factors and bacterial receptor-ligand pr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Bono JL,Keen JE,Clawson ML,Durso LM,Heaton MP,Laegreid WW

    更新日期:2007-08-24 00:00:00

  • Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA.

    abstract:BACKGROUND:Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Yilmaz H,Karakullukcu A,Turan N,Cizmecigil UY,Yilmaz A,Ozkul AA,Aydin O,Gunduz A,Mete M,Zeyrek FY,Kirazoglu TT,Richt JA,Kocazeybek B

    更新日期:2017-08-11 00:00:00

  • Diagnosis and subtype analysis of Blastocystis sp. in 442 patients in a hospital setting in the Netherlands.

    abstract:BACKGROUND:Blastocystis sp. are among the most commonly observed intestinal parasites in routine clinical parasitology. Blastocystis in humans consists of at least 9 genetic subtypes. Different subtypes of Blastocystis may be associated with differences in pathogenicity and symptomatology. METHODS:Advanced microscopy ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Bart A,Wentink-Bonnema EM,Gilis H,Verhaar N,Wassenaar CJ,van Vugt M,Goorhuis A,van Gool T

    更新日期:2013-08-23 00:00:00

  • Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern.

    abstract:BACKGROUND:Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. METHODS:In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Nicolai A,Nenna R,Stefanelli P,Carannante A,Schiavariello C,Pierangeli A,Scagnolari C,Moretti C,Papoff P,Bonci E,Ferrara M,Papasso S,Midulla F

    更新日期:2013-11-08 00:00:00

  • Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies.

    abstract:BACKGROUND:The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its relia...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Ley B,Mtove G,Thriemer K,Amos B,von Seidlein L,Hendriksen I,Mwambuli A,Shoo A,Malahiyo R,Ame SM,Kim DR,Ochiai LR,Clemens JD,Reyburn H,Wilfing H,Magesa S,Deen JL

    更新日期:2010-06-22 00:00:00

  • Missed hepatitis b/c or syphilis diagnosis among Kurdish, Russian, and Somali origin migrants in Finland: linking a population-based survey to the national infectious disease register.

    abstract:BACKGROUND:Migrants are considered a key population at risk for sexually transmitted and blood-borne diseases in Europe. Prevalence data to support the design of infectious diseases screening protocols are scarce. We aimed to estimate the prevalence of hepatitis B and C, human immunodefiency virus (HIV) infection and s...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Tiittala P,Ristola M,Liitsola K,Ollgren J,Koponen P,Surcel HM,Hiltunen-Back E,Davidkin I,Kivelä P

    更新日期:2018-03-20 00:00:00

  • Clonal dissemination of linezolid-resistant Staphylococcus capitis with G2603T mutation in domain V of the 23S rRNA and the cfr gene at a tertiary care hospital in China.

    abstract:BACKGROUND:The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. METHODS:The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain react...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Zhou W,Niu D,Cao X,Ning M,Zhang Z,Shen H,Zhang K

    更新日期:2015-02-26 00:00:00

  • The global effect of maternal education on complete childhood vaccination: a systematic review and meta-analysis.

    abstract:BACKGROUND:There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access and vaccine uptake. Vaccinations are a central preventative child health tool, therefore demonstratin...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Forshaw J,Gerver SM,Gill M,Cooper E,Manikam L,Ward H

    更新日期:2017-12-28 00:00:00

  • Plague in China 2014-All sporadic case report of pneumonic plague.

    abstract:BACKGROUND:Yersinia pestis is the pathogen of the plague and caused three pandemics worldwide. Pneumonic plague is rarer than bubonic and septicemic plague. We report detailed clinical and pathogenic data for all the three sporadic cases of pneumonic plagues in China in 2014. CASE PRESENTATION:All the three patients a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Li YF,Li DB,Shao HS,Li HJ,Han YD

    更新日期:2016-02-19 00:00:00

  • Human papillomavirus genotype distribution in Madrid and correlation with cytological data.

    abstract:BACKGROUND:Cervical cancer is the second most common cancer in women worldwide. Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor associated with cervical cancer. This study analysed the distribution of type-specific HPV infection among women with normal and abnormal cytology...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Martín P,Kilany L,García D,López-García AM,Martín-Azaña MJ,Abraira V,Bellas C

    更新日期:2011-11-15 00:00:00

  • High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South

    abstract:BACKGROUND:There is little information on nasopharyngeal (NP) flora or bacteremia in HIV-infected children. Our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective study comparing daily and three times weekly trimethoprim-sulfamethoxazole (TMP-SMX) and isoniazid...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Cotton MF,Wasserman E,Smit J,Whitelaw A,Zar HJ

    更新日期:2008-04-01 00:00:00

  • A mathematical model of biomedical interventions for HIV prevention among men who have sex with men in China.

    abstract:BACKGROUND:The new HIV treatment guidelines in China recommend antiretroviral therapy (ART) for all people living with HIV, but significant gaps in implementation still exist. Pre-exposure prophylaxis (PrEP) can effectively reduce the risk of HIV transmission among men who have sex with men (MSM). This study assessed t...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Li J,Peng L,Gilmour S,Gu J,Ruan Y,Zou H,Hao C,Hao Y,Lau JT

    更新日期:2018-11-28 00:00:00

  • Gastro-enteritis outbreak among Nordic patients with psoriasis in a health centre in Gran Canaria, Spain: a cohort study.

    abstract:BACKGROUND:Between November 2 and 10, 2002 several patients with psoriasis and personnel staying in the health centre in Gran Canaria, Spain fell ill with diarrhoea, vomiting or both. Patient original came from Norway, Sweden and Finland. The patient group was scheduled to stay until 8 November. A new group of patients...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Eriksen HM,Guerin PJ,Nygård K,Hjertqvist M,de Jong B,Rose AM,Kuusi M,Durr U,Rojas AG,Mør C,Aavitsland P

    更新日期:2004-10-29 00:00:00

  • Incidence and determinants of new AIDS-defining illnesses after HAART initiation in a Senegalese cohort.

    abstract:BACKGROUND:Although a dramatic decrease in AIDS progression has been observed after Highly Active Anti Retroviral Therapy (HAART) in both low- and high-resource settings, few data support that fact in low-resource settings.This study describes the incidence of AIDS-defining illnesses (ADI) after HAART initiation and an...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: De Beaudrap P,Etard JF,Diouf A,Ndiaye I,Ndèye GF,Sow PS,Ndèye KC,Ecochard R,Delaporte E,ANRS 1215 Study Group.

    更新日期:2010-06-19 00:00:00

  • Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea.

    abstract:BACKGROUND:Viral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Laman M,Hwaiwhanje I,Bona C,Warrel J,Aipit S,Smith D,Noronha J,Siba P,Mueller I,Betuela I,Davis TM,Manning L

    更新日期:2014-11-26 00:00:00

  • The impact of community-acquired pneumonia on the health-related quality-of-life in elderly.

    abstract:BACKGROUND:The sustained health-related quality-of-life of patients surviving community-acquired pneumonia has not been accurately quantified. The aim of the current study was to quantify differences in health-related quality-of-life of community-dwelling elderly with and without community-acquired pneumonia during a 1...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Mangen MJ,Huijts SM,Bonten MJ,de Wit GA

    更新日期:2017-03-14 00:00:00

  • A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report.

    abstract:BACKGROUND:A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. CASE PRESENTATION:The patient presented with 1 week of weakness, dyspnea, and ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Kofman AD,Sizemore EK,Detelich JF,Albrecht B,Piantadosi AL

    更新日期:2020-09-29 00:00:00

  • Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA.

    abstract:BACKGROUND:Antibiotic resistant strains of Acinetobacter baumannii have been responsible for an increasing number of nosocomial infections including bacteremia and ventilator-associated pneumonia. In this study, we analyzed 38 isolates of A. baumannii obtained from two hospital outbreaks in Los Angeles County for the m...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Warner WA,Kuang SN,Hernandez R,Chong MC,Ewing PJ,Fleischer J,Meng J,Chu S,Terashita D,English L,Chen W,Xu HH

    更新日期:2016-05-04 00:00:00

  • Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities.

    abstract:BACKGROUND:Antimicrobial resistance (AMR) is a major challenge for global health care. Pharmacists play a key role in the health care setting to help support the quality use of medicines. The education, training, and experiences of pharmacy students have the potential to impact on patterns of antibiotic use in communit...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Sakeena MHF,Bennett AA,Jamshed S,Mohamed F,Herath DR,Gawarammana I,McLachlan AJ

    更新日期:2018-05-08 00:00:00

  • The role of resuscitation promoting factors in pathogenesis and reactivation of Mycobacterium tuberculosis during intra-peritoneal infection in mice.

    abstract:BACKGROUND:Mycobacterium tuberculosis can enter into a dormant state which has resulted in one third of the world's population being infected with latent tuberculosis making the study of latency and reactivation of utmost importance. M. tuberculosis encodes five resuscitation promoting factors (Rpfs) that bear strong s...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Biketov S,Potapov V,Ganina E,Downing K,Kana BD,Kaprelyants A

    更新日期:2007-12-17 00:00:00

  • Lemierre's syndrome and genetic polymorphisms: a case report.

    abstract:BACKGROUND:Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host detection of pathogen or the resultant systemic reaction. CASE PRESENTATION:A 17-year old female, with no previous medical hist...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Constantin JM,Mira JP,Guerin R,Cayot-Constantin S,Lesens O,Gourdon F,Romaszko JP,Linval P,Laurichesse H,Bazin JE

    更新日期:2006-07-17 00:00:00

  • A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study.

    abstract:BACKGROUND:The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. METHODS:The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Doulou S,Leventogiannis K,Tsilika M,Rodencal M,Katrini K,Antonakos N,Kyprianou M,Karofylakis E,Karageorgos A,Koufargyris P,Christopoulos G,Kassianidis G,Stamatelopoulos K,Newberry R,Giamarellos-Bourboulis EJ

    更新日期:2020-11-19 00:00:00

  • Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China.

    abstract:BACKGROUND:No comparison data have been reported on viral and epidemiological profiles of hospitalized children with severe acute respiratory infection (SARI) in Beijing or Shanghai, China. METHODS:We collected 700 nasopharyngeal aspirates (NPA) from hospitalized children with SARI in Beijing (northern China) and Shan...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Zhao Y,Lu R,Shen J,Xie Z,Liu G,Tan W

    更新日期:2019-08-20 00:00:00

  • Treatment challenges for urogenital and anorectal Chlamydia trachomatis.

    abstract::While true antimicrobial resistance to Chlamydia trachomatis is a rare occurrence, repeat chlamydia infections continue to be reported following treatment with a single 1 g dose of azithromycin or week long doxycycline - with considerable more concern about azithromycin treatment failure. While most repeat positive ca...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审


    authors: Kong FY,Hocking JS

    更新日期:2015-07-29 00:00:00

  • Bacterial vaginosis, vaginal flora patterns and vaginal hygiene practices in patients presenting with vaginal discharge syndrome in The Gambia, West Africa.

    abstract:BACKGROUND:Bacterial vaginosis (BV) - a syndrome characterised by a shift in vaginal flora - appears to be particularly common in sub-Saharan Africa, but little is known of the pattern of vaginal flora associated with BV in Africa. We conducted a study aimed at determining the prevalence of BV and patterns of BV-associ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Demba E,Morison L,van der Loeff MS,Awasana AA,Gooding E,Bailey R,Mayaud P,West B

    更新日期:2005-03-09 00:00:00

  • Evaluation of alternative respiratory syndromes for specific syndromic surveillance of influenza and respiratory syncytial virus: a time series analysis.

    abstract:BACKGROUND:Syndromic surveillance is increasingly being evaluated for its potential for early warning of increased disease activity in the population. However, interpretation is hampered by the difficulty of attributing a causative pathogen. We described the temporal relationship between laboratory counts of influenza ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Schindeler SK,Muscatello DJ,Ferson MJ,Rogers KD,Grant P,Churches T

    更新日期:2009-11-29 00:00:00

  • Distribution of serotypes and patterns of antimicrobial resistance among commensal Streptococcus pneumoniae in nine European countries.

    abstract:BACKGROUND:Streptococcus pneumoniae is a commensal of the human upper respiratory tract and a major cause of morbidity and mortality worldwide. This paper presents the distribution of serotypes and antimicrobial resistance in commensal S. pneumoniae strains cultured from healthy carriers older than four years of age in...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Yahiaoui RY,Bootsma HJ,den Heijer CDJ,Pluister GN,John Paget W,Spreeuwenberg P,Trzcinski K,Stobberingh EE

    更新日期:2018-08-29 00:00:00

  • Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage.

    abstract:BACKGROUND:To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS:From September 2014 to November 201...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Hsu YY,Wu D,Hung CC,Huang SS,Yuan FH,Lee MH,Huang CT,Shie SS,Huang PY,Yang CC,Cheng CW,Leu HS,Wu TS,Huang YC

    更新日期:2020-03-30 00:00:00

  • Peritonitis secondary to hemorrhagic fever with renal syndrome: a case report in GuangZhou China.

    abstract:BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Huang N,Liu N,Lu J

    更新日期:2020-01-13 00:00:00

  • Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

    abstract:BACKGROUND:Large scale administration of the anthelminthic drug praziquantel (PZQ) to at-risk populations is the cornerstone of schistosomiasis control, although persisting high prevalence of infections in some areas and growing concerns of PZQ resistance have revealed the limitations of this strategy. Most studies ass...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,随机对照试验


    authors: Hoekstra PT,Casacuberta Partal M,Amoah AS,van Lieshout L,Corstjens PLAM,Tsonaka S,Assaré RK,Silué KD,Meité A,N'Goran EK,N'Gbesso YK,Roestenberg M,Knopp S,Utzinger J,Coulibaly JT,van Dam GJ

    更新日期:2018-12-14 00:00:00