Abstract:
BACKGROUND:The staphylococci are implicated in a variety of human infections; however, many clinical microbiology laboratories in Nigeria do not identify staphylococci (in particular coagulase negative staphylococci - CNS) to the species level. Moreover, data from multi-centre assessment on antibiotic resistance and epidemiology of the staphylococci are not available in Nigeria. This study investigated 91 non-duplicate staphylococcal isolates obtained from the microbiology laboratories of eight hospitals in Nigeria during the period January to April 2010. METHODS:Identification and antibiotic susceptibility testing was performed using the VITEK 2 system, detection of resistance genes by PCR, and molecular characterization was determined by SCCmec typing, spa and multilocus sequence typing (MLST). RESULTS:All the isolates were susceptible to mupirocin, tigecycline, vancomycin and linezolid, but 72.5% of CNS and 82.3% of Staphylococcus aureus were resistant to cotrimoxazole, while multiresistance was observed in 37 of the 40 CNS isolates. Untypeable SCCmec types (ccrC/Class A mec and ccr-negative/Class C2 mec gene complex) in two methicillin-resistant S. aureus (MRSA) were identified. Additionally, ccr-negative/Class A mec and ccr type 4/Class C2 mec gene complex was detected in one isolate each of S. sciuri and S. haemolyticus, respectively. The S. aureus isolates were classified into 21 spa types including two new types (t8987, t9008) among the methicillin-susceptible S. aureus (MSSA) isolates. Two (CC8-SCCmecnon-typeable and CC88-SCCmec IV) and four (CC8-SCCmec III/IV/V; CC30-SCCmec II/III; CC88-SCCmec IV; and ST152-SCCmecnon-typeable) MRSA clones were identified in Maiduguri (North-East Nigeria) and South-West Nigeria, respectively. The proportion of Panton-Valentine leukocidin (PVL)-positive MSSA was high (44.4%) and 56.3% of these strains were associated with sequence type (ST) 152. CONCLUSIONS:The identification of multiresistant mecA positive S. haemolyticus and S. sciuri from clinical samples indicates that characterization of CNS is important in providing information on their diversity and importance in Nigeria. There is the need to develop new SCCmec classification methods for non-typeable methicillin-resistant staphylococci, and to curtail the spread and establishment of the S. aureus ST152 clone in Nigeria. The study presents the first report of a PVL-positive ST152-SCCmecnontypeable MRSA and SCCmec typing of methicillin-resistant CNS in Nigeria.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Shittu A,Oyedara O,Abegunrin F,Okon K,Raji A,Taiwo S,Ogunsola F,Onyedibe K,Elisha Gdoi
10.1186/1471-2334-12-286subject
Has Abstractpub_date
2012-11-02 00:00:00pages
286issn
1471-2334pii
1471-2334-12-286journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Refugees in sub-Saharan Africa face both the risk of HIV infection and barriers to HIV testing. We conducted a pilot study to determine the feasibility and acceptability of home-based HIV testing in Nakivale Refugee Settlement in Uganda and to compare home-based and clinic-based testing participants in Nakiv...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3238-y
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of death from infectious diseases worldwide. Sputum smear microscopy remains the most widely available pulmonary TB diagnostic tool particularly in resource limited settings. A highly sensitive diagnostic with minimal infrast...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2140-8
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:This randomized controlled trial aimed to evaluate whether the serum procalcitonin (PCT) level can be utilized to guide the use of antibiotics in the treatment of acute exacerbations of asthma. METHODS:A total of 293 consecutive patients with suspected asthma attacks from February 2005 to July 2010 particip...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-13-596
更新日期:2013-12-17 00:00:00
abstract:BACKGROUND:Rituximab, a monoclonal antibody directed against CD20, is approved for the treatment of CD20-positive B-cell Non-Hodgkin's lymphoma and rheumatologic disorders. Due to its potent activity in depleting CD20-positive lymphocytes, the influence on opportunistic infections is still under discussion. Thus, we an...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-364
更新日期:2014-07-03 00:00:00
abstract:BACKGROUND:Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-resistant tuberculosis (TB). METHODS:We evaluated retrospectively the treatmen...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-6
更新日期:2008-01-23 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) markedly reduces HIV transmission, and testing and treatment programs have been advocated as a method for decreasing transmission at the population level. Little is known, however, about the extent to which sexually transmitted infections (STIs), which increase the HIV infectious...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-015-0961-5
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:Specific land cover types and activities have been correlated with Trypanosoma brucei rhodesiense distributions, indicating the importance of landscape for epidemiological risk. However, methods proposed to identify specific areas with elevated epidemiological risk (i.e. where transmission is more likely to ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-316
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Identifying immunogens that induce HIV-1-specific immune responses is a lengthy process that can benefit from computational methods, which predict T-cell epitopes for various HLA types. METHODS:We tested the performance of the NetMHCpan4.0 computational neural network in re-identifying 93 T-cell epitopes th...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4876-4
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children in Ethiopia. METHODS:We model the mosquito abundance and time to malaria data jointly in a Bayesian framework. RE...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2496-4
更新日期:2017-06-12 00:00:00
abstract:BACKGROUND:This study is to elucidate the disinfection effect of ozone producing low-pressure Hg vapor lamps against human pathogens. Ozone producing low-pressure Hg vapor lamps emit mainly 254 nm ultraviolet light C (UVC) with about 10% power of Vacuum-ultraviolet (VUV) light at 185 nm. The combination of UVC and VUV ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4847-9
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Guidelines from the Infectious Diseases Society of America/The American Thoracic Society (IDSA/ATS) provide recommendations for diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the mere presence of guidelines is rarely sufficient to promote widespread adoption and uptake. Using the ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1665-1
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce. METHODS:21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to imm...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2651-y
更新日期:2017-08-08 00:00:00
abstract:BACKGROUND:While cultivation of pathogens represents a foundational diagnostic approach in the study of infectious diseases, its value for the confirmation of clinical diagnosis of Buruli ulcer is limited by the fact that colonies of Mycobacterium ulcerans appear only after about eight weeks of incubation at 30°C. Howe...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0636-7
更新日期:2014-11-30 00:00:00
abstract:BACKGROUND:Blastocystis sp. are among the most commonly observed intestinal parasites in routine clinical parasitology. Blastocystis in humans consists of at least 9 genetic subtypes. Different subtypes of Blastocystis may be associated with differences in pathogenicity and symptomatology. METHODS:Advanced microscopy ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-389
更新日期:2013-08-23 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis is a common sexually transmitted infection in Australia. This report aims to measure the burden of chlamydia infection by systematically reviewing reports on prevalence in Australian populations. METHODS:Electronic databases and conference websites were searched from 1997-2011 using th...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2334-12-113
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:There currently is a severe Zika Virus (ZIKV) epidemic in Brazil and other South American countries. Due to international travel, this poses severe public health risk of ZIKV importation to other countries. We estimate the prevalence of ZIKV in an import region by the time a microcephaly case is detected, si...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2076-z
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND:Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptide-based therapeutic vaccine candidate corresponding to C5/gp41732-744 as well as the effects on pre-...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-017-2316-x
更新日期:2017-03-24 00:00:00
abstract:BACKGROUND:The inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates the need for acquirement of reliable and standard diagnostic reagents. Recently, epitope-based antigens have emerged as an alternative diagnostic marker for the achievemen...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2920-9
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. METHODS:The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain react...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0841-z
更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Antimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority. METHODS:We examined recent time trends in the utilization of narrow- and broad-spectrum antibio...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3964-9
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases including cancer. METHODS:The study investigated the prognostic role of soluble MICB (sMICB) protein...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0754-x
更新日期:2015-01-23 00:00:00
abstract:BACKGROUND:Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-bauma...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1678-9
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there is unacceptably high treatment gap of 62.1% between cases estimated and cases detected. Therefore calls fo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3036-6
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda. METHODS:HIV-negative, high-risk women were seen q...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-333
更新日期:2011-12-02 00:00:00
abstract:BACKGROUND:Collecting adequate information on key epidemiological indicators is a prerequisite to informing a public health response to reduce the impact of hepatitis C virus (HCV) infection in Malaysia. Our goal was to overcome the acute data shortage typical of low/middle income countries using statistical modelling ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0564-6
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:Brucellosis is endemic in many areas in China. The current diagnosis of Brucellosis predominantly relies on the traditional bacterial culture and serum agglutination test. In this study, we aimed to explore the value of ELISA in the diagnosis of Brucellosis in Chinese population. METHODS:We recruited 235 pa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4729-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Efficient control and management in the ongoing COVID-19 pandemic needs to carefully balance economical and realizable interventions. Simulation models can play a cardinal role in forecasting possible scenarios to sustain decision support. METHODS:We present a sophisticated extension of a classical SEIR mod...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05566-7
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished to explore temporal trends of OAI caused by Group A Streptococci (GAS), Group B Streptococci (GBS...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1874-7
更新日期:2016-10-04 00:00:00
abstract:BACKGROUND/AIM:Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2793-y
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND:Scabies is an infectious disease that affects the skin caused by the mite Sarcoptes scabiei and it transmitted through close personal contact. Even though it is easily treatable disease, its prevalence is high and continuous as neglected tropical disease of resource-poor settings, and particularly affects yo...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-020-05106-3
更新日期:2020-05-27 00:00:00