Abstract:
BACKGROUND:The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda. METHODS:HIV-negative, high-risk women were seen quarterly for one year, and once in Year 2. HIV serostatus, clinical, and behavioral information were assessed at each visit, HPV types at Month 6 and Year 2, and other sexually transmitted infections (STI) at selected visits. HPV prevalence was also assessed in HIV-positive, high-risk women. RESULTS:Prevalence of any HPV was 47.0% in HIV-negative women (median age 25 years) compared to 72.2% in HIV-positive women (median age 27 years; OR 2.9, 95% CI 1.9-4.6). Among HIV-negative women, cumulative incidence of high-risk (HR)-HPV was 28.0% and persistence 32.0% after a mean period of 16.6 and 16.9 months, respectively. Prior Chlamydia trachomatis and Neisseria gonorrhoeae infection, concurrent low-risk (LR)-HPV infection and incident HSV-2 were associated with HR-HPV prevalence among HIV-negative women; prior C. trachomatis infection and co-infection with LR-HPV and HPV16-related HPV types with HR-HPV acquisition. HPV16-related types were the most prevalent and persistent. CONCLUSIONS:High HPV prevalence, incidence and persistence were found among high-risk women in Kigali. HPV52 had the highest incidence; and, together with HPV33 and HPV58, were strongly associated with acquisition of other HR-HPV types in HIV-negative women.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Veldhuijzen NJ,Braunstein SL,Vyankandondera J,Ingabire C,Ntirushwa J,Kestelyn E,Tuijn C,Wit FW,Umutoni A,Uwineza M,Crucitti T,van de Wijgert JHdoi
10.1186/1471-2334-11-333subject
Has Abstractpub_date
2011-12-02 00:00:00pages
333issn
1471-2334pii
1471-2334-11-333journal_volume
11pub_type
杂志文章abstract:BACKGROUND:The herpes zoster burden of disease in Sweden is not well investigated. There is no Swedish immunization program to prevent varicella zoster virus infections. A vaccine against herpes zoster and its complications is now available. The aim of this study was to estimate the herpes zoster burden of disease and ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 已发布勘误
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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