Abstract:
BACKGROUND:HIV self-testing (HIVST) can be performed using directly assisted and unassisted approaches in facilities or communities to reach different populations. The aim of this study was to compare the practicability and effectiveness of the two delivery approaches for HIVST, unassisted HIVST (UH) and directly assisted HIVST (DAH), in the field setting of Kisangani, the Democratic Republic of the Congo (DRC). METHODS:A randomized (1:1), non-blinded, non-inferiority trial using a blood-based and facility-based HIVST method was carried out in four facilities in Kisangani, the DRC, targeting populations at high risk for HIV infection. The primary outcome was the difference in the practicability of the HIV self-test between the two arms. Practicability was defined as successfully performing the test and correctly interpreting the result. Requests for assistance, positivity rate, linkage to care, and willingness to buy an HIV self-test kit constituted the secondary outcomes for HIVST effectiveness. The adjusted risk ratios (aRRs) were calculated using Poisson regression. RESULTS:The rate of successfully performing the test was same (93.2%) in the UH and DAH arms. The rate of correctly interpreting the results was 86.9% in the UH arm versus 93.2% in the DAH arm, for a difference of - 6.3%. After the follow-up 72 h later, participants in the UH arm had a significantly lower chance of correctly interpreting the test results than those in the DAH arm (aRR: 0.60; P = 0.019). Although the positivity rate was 3.4% among the participants in the DAH arm and 1.7% among those in the UH arm, no significant differences were found between the two arms in the positivity rate, requests for assistance, and linkage to care. Willingness to buy an HIV self-test was higher in the UH arm than in the DAH arm (92.3% versus 74.1%; aRR: 4.20; P < 0.001). CONCLUSION:The results of this study indicate that UH is as practicable and effective as DAH among individuals at high risk for HIV infection in Kisangani, the DRC. However, additional support tools need to be assessed to improve the interpretation of the self-test results when using the UH approach. TRIAL REGISTRATION:PACTR201904546865585. Registered 03 April 2019 - Retrospectively registered, https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=6032.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Tonen-Wolyec S,Kayembe Tshilumba C,Batina-Agasa S,Marini Djang'eing'a R,Hayette MP,Belec Ldoi
10.1186/s12879-020-05554-xsubject
Has Abstractpub_date
2020-11-11 00:00:00pages
830issue
1issn
1471-2334pii
10.1186/s12879-020-05554-xjournal_volume
20pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has been increased not only in the hospital but also in the community worldwide. This study was aimed to characterize ESBL- producing E. coli isolates and to investigate the molecular epidemiology of community isolates in compa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-149
更新日期:2012-06-29 00:00:00
abstract:BACKGROUND:Following delivery by caesarean section, surgical site infection is the most common infectious complication. Despite a large number of caesarean sections performed at Debre Markos Referral Hospital, there was no study documenting the incidence of surgical site infection after caesarean section. Therefore, th...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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abstract::Following publication. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12879-019-3739-3
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus (S.) pneumoniae. CCAAT/enhancer binding protein δ is a transcription factor that has recently been hypothesized to play a detrimental role in outcome of meningitis caused by S. pneumoniae. Here, we studie...
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pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND:Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, attitude and practice of the community in endemic areas are scanty. The study aimed to assess the knowledge, attitude towards cutaneous leishmaniasis and treatment seeking prac...
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abstract:BACKGROUND:Several highly pathogenic avian influenza (AI) outbreaks have been reported over the past decade. South Korea recently faced AI outbreaks whose economic impact was estimated to be 6.3 billion dollars, equivalent to nearly 50% of the profit generated by the poultry-related industries in 2008. In addition, AI ...
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pub_type: 杂志文章
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更新日期:2010-08-10 00:00:00
abstract:BACKGROUND:Data regarding HIV-seronegative pediatric patients with cryptococcal meningitis (CM) have been very limited. METHODS:We retrospectively reviewed non-HIV-infected in patients with CM from January 2002 through December 2013 in Beijing Children's Hospital. Records of the all patients were obtained and compared...
journal_title:BMC infectious diseases
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doi:10.1186/s12879-016-1964-6
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更新日期:2008-04-10 00:00:00
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更新日期:2010-06-15 00:00:00
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doi:10.1186/1471-2334-13-306
更新日期:2013-07-03 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:Statin use is associated with a modest increase in the incidence of type 2 diabetes mellitus (DM) among the general population. However, HIV-infected patients have a higher risk of developing DM, and it is unclear whether statins have a diabetogenic effect in these patients. Therefore, we investigated the as...
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更新日期:2017-01-07 00:00:00
abstract:BACKGROUND:Oxidative stress plays a vital role in the pathogenesis of both Sickle Cell Disease (SCD) and Plasmodium falciparum malaria. However, there are limited studies on the effect of P. falciparum malaria infection on oxidative stress in SCD patients. METHODS:A cross-sectional study was undertaken to compare leve...
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abstract:BACKGROUND:Due to limited therapeutic options, the spread of extended-spectrum beta-lactamases (ESBLs) have become a major public health concern. We conducted a prospective, randomized, open-label comparison of the therapeutic efficacy of piperacillin-tazobactam (PTZ), cefepime, and ertapenem in febrile nosocomial urin...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:In chronic hepatitis C, the fibrosis progression rates are extremely variable and can be influenced by factors associated with the host, virus and environment. Among the associated metabolic factors, hepatic steatosis is characterized by an accumulation of triglycerides in hepatocytes. In the host, genetic d...
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doi:10.1186/s12879-017-2340-x
更新日期:2017-03-29 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2011-12-28 00:00:00
abstract:BACKGROUND:Dengue, a viral disease transmitted by Aedes mosquitoes, is an important public health concern throughout Thailand. Climate variables are potential predictors of dengue transmission. Associations between climate variables and dengue have usually been performed on large-scale first-level national administrati...
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