Abstract:
BACKGROUND:Sepsis is a life-threatening situation, and it can be rendered more severe by coagulopathy. We here examine a novel plasma biomarker for sepsis-induced coagulopathy. METHODS:A total of 116 patients diagnosed with sepsis were recruited and divided into two groups by whether they also had coagulopathy. Plasma samples were collected on arrival at the intensive care unit. Fifteen sepsis-alone and 15 sepsis-induced coagulopathy plasma samples were mixed and sent for microRNA sequencing. Differently expressed microRNAs were then validated by quantitative reverse transcriptase polymerase chain reaction in 52 sepsis-alone and 34 sepsis-induced coagulopathy patients; plasma lipocalin-2 was measured as well. RESULTS:Four microRNAs were selected from microRNA sequencing. Only hsa-mir-92a-3p was differently expressed in the validation set. Its level of expression was significantly lower in sepsis-induced coagulopathy group. Hsa-mir-92a-3p had an area under a receiver operating characteristic curve of 0.660 (95% confidence interval, 0.537, 0.782). The plasma Hsa-mir-92a-3p level was related to activated partial thromboplastin time, prothrombin activity, and plasma lipocalin-2 level. A binary logistic model showed an association between hsa-mir-92a-3p and fibrinogen with SIC. CONCLUSIONS:The utility of hsa-mir-92a-3p as a biomarker for sepsis-induced coagulopathy needs more verification, and the regulatory mechanism of hsa-mir-92a-3p in coagulation disorder and its potency as a therapeutic target must be confirmed.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Wang Y,Wang H,Zhang C,Zhang C,Yang H,Gao R,Tong Zdoi
10.1186/s12879-020-4853-ysubject
Has Abstractpub_date
2020-02-19 00:00:00pages
155issue
1issn
1471-2334pii
10.1186/s12879-020-4853-yjournal_volume
20pub_type
杂志文章abstract:BACKGROUND:Staphylococcus aureus strains are now regarded as zoonotic agents. In pastoral settings where human-animal interaction is intimate, multi-drug resistant microorganisms have become an emerging zoonotic issue of public health concern. The study of S. aureus prevalence, antimicrobial resistance and clonal linea...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2524-4
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0882-3
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:In Finland, the annual number of MRSA notifications to the National Infectious Disease Register (NIDR) has constantly increased since 1995, and molecular typing has revealed numerous outbreak isolates of MRSA. We analyzed the data on MRSA notifications of the NIDR, and MRSA isolates were identified mainly by...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-94
更新日期:2007-08-14 00:00:00
abstract:BACKGROUND:Antimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority. METHODS:We examined recent time trends in the utilization of narrow- and broad-spectrum antibio...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3964-9
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) represent an important global threat. The aim of this study is to describe the clinical course and outcomes of patients with CRE infections treated with ceftazidime-avibactam (CAZ-AVI) compared to patients treated with other agents. METHODS:A retrospective cohor...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4409-1
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality. Treatment of malaria in a timely manner could avert deaths. Treatment ultimately relies on the rapid and accurate diagnosis. Fluorescence in situ hybridization (FISH), a cytogenetic technique based on detection of specific nucleic acid, has the potential t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2875-x
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical o...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-264
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:Patients asking for a free anonymous HIV test may have contracted other sexually transmitted infections (STIs) such as Chlamydia trachomatis, yet Chlamydia prevalence in that population is unknown. This study aimed to assess the prevalence and factors associated with Chlamydia infection in patients seeking H...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1915-2
更新日期:2016-10-26 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) infections have become increasingly prevalent in certain European countries, including Hungary. Although most human infections do not cause severe symptoms, in approximately 1% of cases WNV infections can lead to severe WNV neuroinvasive disease (WNND) and death. The goal of our study w...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05760-7
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the dev...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3690-3
更新日期:2019-01-16 00:00:00
abstract:BACKGROUND:Prisoners represent a vulnerable population for blood-borne and sexually transmitted infections which can potentially lead to liver fibrosis and ultimately cirrhosis. However, little is known about the prevalence of liver fibrosis and associated risk factors among inmates in sub-Saharan Africa. METHODS:Scre...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1601-4
更新日期:2016-06-06 00:00:00
abstract:BACKGROUND:Although various studies have demonstrated efficacy of DNA-recombinant anti-hepatitis B vaccines, their effectiveness in health care settings has not been researched adequately. This gap is particularly visible for blood donors, a group of significant importance in the reduction of transfusion-transmitted he...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2334-7-124
更新日期:2007-11-06 00:00:00
abstract:BACKGROUND:A birth cohort dedicated to studying infections in early childhood may be assisted by parental recording of symptoms on a daily basis and a collection of biomaterials. We aimed at testing the feasibility of this approach for use in a long-term study focusing on infections in children in Germany. METHODS:Par...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1189-0
更新日期:2015-10-22 00:00:00
abstract:BACKGROUND:In Germany, 17% of the general human population have antibodies to hepatitis E virus (HEV) (recomLine HEV-IgG/IgM immunoassay [Mikrogen GmbH]). Wild boars represent an animal reservoir for HEV genotype 3, which is the common genotype in Germany. We estimated the seroprevalence among hunters with contact to w...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1199-y
更新日期:2015-10-22 00:00:00
abstract:BACKGROUND:Candida parapsilosis was the most common species causing candidemia in the 2010 China Hospital Invasive Fungal Surveillance Net (CHIF-NET) database. Compared to Candida albicans, the description of azole resistance and mechanisms in C. parapsilosis is very limited. We report a patient with C. parapsilosis ca...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1086-6
更新日期:2015-08-18 00:00:00
abstract:BACKGROUND:Oxidative stress plays a vital role in the pathogenesis of both Sickle Cell Disease (SCD) and Plasmodium falciparum malaria. However, there are limited studies on the effect of P. falciparum malaria infection on oxidative stress in SCD patients. METHODS:A cross-sectional study was undertaken to compare leve...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4221-y
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-32
更新日期:2008-03-06 00:00:00
abstract:BACKGROUND:The outbreak of the novel coronavirus (COVID-19) that was firstly reported in Wuhan, China, with cases now confirmed in more than 100 countries. However, COVID-19 pneumonia with spontaneous pneumothorax is unknown. CASE PRESENTATION:We reported a case of 66-year-old man infected with COVID-19, presenting wi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05384-x
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Severe infection is a main cause of mortality. We aim to describe risk factors for long-term mortality among inpatients with severe infection. METHODS:Prospective cohort study in a 600-bed university hospital in Portugal including all patients with severe infection admitted into intensive care, medical, sur...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3054-4
更新日期:2018-04-05 00:00:00
abstract:BACKGROUND:HIV self-testing (HIVST) can be performed using directly assisted and unassisted approaches in facilities or communities to reach different populations. The aim of this study was to compare the practicability and effectiveness of the two delivery approaches for HIVST, unassisted HIVST (UH) and directly assis...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-020-05554-x
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Anisakid nematodes (Anisakis spp. or Pseudoterranova spp.) usually infect gastric or intestinal walls, while they rarely infect in extra-gastrointestinal sites of human body. Generally, Anisakis spp. larvae are highly infected in fish intermediate hosts, whereas Pseudoterranova spp. larvae are very rarely in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3540-8
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:High seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-375
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished to explore temporal trends of OAI caused by Group A Streptococci (GAS), Group B Streptococci (GBS...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1874-7
更新日期:2016-10-04 00:00:00
abstract:BACKGROUND:Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2567-6
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:The Belgian HIV epidemic is largely concentrated among men who have sex with men and Sub-Saharan Africans. We studied the continuum of HIV care of those diagnosed with HIV living in Belgium and its associated factors. METHODS:Data on new HIV diagnoses 2007-2010 and HIV-infected patients in care in 2010-2011...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1230-3
更新日期:2015-11-03 00:00:00
abstract:BACKGROUND:There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access and vaccine uptake. Vaccinations are a central preventative child health tool, therefore demonstratin...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-017-2890-y
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:The low uptake of facility-based HIV counseling and testing (HCT) in South Africa, particularly amongst men and youth has hindered attempts to increase access to effective treatment and prevention strategies. Many barriers to HIV testing have been described including long waiting times, transport to reach fa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-73
更新日期:2012-03-29 00:00:00
abstract:BACKGROUND:In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-47
更新日期:2009-04-22 00:00:00
abstract:BACKGROUND:Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso. METHODS:Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urb...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-164
更新日期:2013-04-04 00:00:00
abstract:BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyr...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12879-015-0963-3
更新日期:2015-06-12 00:00:00