Abstract:
BACKGROUND:Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons and to assess if the screening method is a suitable tool to monitor influenza VE in this particular target-group in Germany. METHODS:We identified laboratory-confirmed influenza cases aged 60+ years through the national communicable disease reporting system for seasons 2010/11, 2011/12 and 2012/13. Vaccination coverage (VC) data were retrieved from a database of health insurance claims representing ~85% of the total German population. We applied the screening method to calculate influenza subtype-specific VE and compared our results with VE estimates from other observational studies in Europe. RESULTS:In total, 7,156 laboratory-confirmed influenza cases were included. VE against all influenza types ranged between 49% (95% confidence interval [CI]: 39-56) in 2011/12 and 80% (95% CI: 76-83%) in 2010/11. In 2010/11 subtype-specific VE against influenza A(H1N1)pdm and B was 76% and 84%, respectively. In the following seasons, VE against influenza A(H1N1)pdm, A(H3N2) and B was 87%, -9% , 74% (2011/12), and 74%, 39%, 73% (2012/13). VE was higher among hospitalized compared to non-hospitalized influenza A cases. Seventeen observational studies from Europe reporting subtype-specific VE among the elderly were identified for the respective seasons (all applying the test-negative design) and showed comparable subtype-specific VE estimates. CONCLUSIONS:According to our study, influenza vaccination provided moderate protection against laboratory-confirmed influenza A(H1N1)pdm and B in individuals aged 60+ but no or only little protection against A(H3N2). Higher VE among hospitalized cases might indicate higher protection against severe influenza disease. Based on the available data, the screening method allowed us to assess subtype-specific VE in hospitalized and non-hospitalized elderly persons. Since controlling for several important confounders was not possible, the applied method only provided crude VE estimates. However, given the precise VC-data and the large number of cases, the screening method provided results being in line with VE estimates from other observational studies in Europe that applied a different study design.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Remschmidt C,Rieck T,Bödeker B,Wichmann Odoi
10.1186/s12879-015-0882-3subject
Has Abstractpub_date
2015-03-20 00:00:00pages
137issn
1471-2334pii
10.1186/s12879-015-0882-3journal_volume
15pub_type
杂志文章abstract:BACKGROUND:The low uptake of facility-based HIV counseling and testing (HCT) in South Africa, particularly amongst men and youth has hindered attempts to increase access to effective treatment and prevention strategies. Many barriers to HIV testing have been described including long waiting times, transport to reach fa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-73
更新日期:2012-03-29 00:00:00
abstract:BACKGROUND:To verify whether a daily service of Infectious Diseases consultation (ID-cons) is more effective than a weekly service in reducing antibiotic (ATB) consumption without worsening of clinical outcomes. METHODS:Two-year observational analysis of the ID-cons provided in a hospital setting in Milan, Italy. ID-c...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05550-1
更新日期:2020-11-07 00:00:00
abstract:BACKGROUND:Estimation of pre-immunisation prevalence of HPV and distribution of HPV types is fundamental to understanding the subsequent impact of HPV vaccination. We describe the type specific prevalence of HPV in females aged 20-21 in Scotland who attended or defaulted from cervical screening using three specimen typ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-519
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:Relapse of tuberculosis (TB) may develop as the result of reactivation of the endogenous primary infection, or as a result of a exogenous reinfection. This survey evaluated the rate of reactivation versus recent transmission among Iranian and Afghan relapse cases. METHODS:The sputum specimens were digested,...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-109
更新日期:2008-08-06 00:00:00
abstract:BACKGROUND:At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred. METHODS:Immunogenicity and safety were assessed in 871 healthy subjects aged 19-40 years who were randomised into ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-12-279
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Kynurenine/Tryptophan ratio (KTR) is increased in HIV infection, and linked to immune activation. We hypothesized that early cART initiation results in lower KTR compared to late initiation. Furthermore, we hypothesized that KTR prior to cART is a predictor of the magnitude of subsequent reduction in immune ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2456-z
更新日期:2017-05-16 00:00:00
abstract:BACKGROUND:Antimicrobial resistance (AMR) is a major challenge for global health care. Pharmacists play a key role in the health care setting to help support the quality use of medicines. The education, training, and experiences of pharmacy students have the potential to impact on patterns of antibiotic use in communit...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3107-8
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Plasma proteins are known to interfere the drug metabolism during therapy. As limited information is available regarding the role of plasma proteins in HIV drug resistance during ART in HIV/AIDS patients, the present study aimed to identify and characterize the differentially expressed plasma proteins in the...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05610-6
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:Information about improvements in the health status of population at-risk of helminth infection after anthelminthic treatment helps to evaluate the effectiveness of the large scale deworming program. The objectives of this study were to assess the impact of anthelminthic treatment on the prevalence and inten...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1956-6
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:Measles is a highly infectious viral disease. In August 2017, Lyantonde District, Uganda reported a measles outbreak to Uganda Ministry of Health. We investigated the outbreak to assess the scope, factors facilitating transmission, and recommend control measures. METHODS:We defined a probable case as sudden...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05120-5
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-015-0843-x
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:HIV-associated neurocognitive disorder (HAND) remains prevalent in the era of combination antiretroviral therapy (cART). The prevalence of HAND in Hong Kong is not known. METHODS:Between 2013 and 2015, 98 treatment-naïve HIV-1-infected individuals were referred to and screened by the AIDS Clinical Service, ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3784-y
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2674-4
更新日期:2017-08-18 00:00:00
abstract:BACKGROUND:Under-reporting of tuberculosis (TB) cases complicates disease control, hinders contact tracing and alters the accuracy of epidemiological data, including disease burden. The objective of the present study is to evaluate the proportion of unreported TB cases in Spanish healthcare facilities and to identify t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1047-0
更新日期:2015-07-29 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) DNA levels are crucial for managing chronic hepatitis B (CHB). It was unclear whether Daan real-time polymerase chain reaction test (Daan test) or COBAS TaqMan HBV DNA Test (Cobas TaqMan) was superior in measuring different HBV DNA levels in clinical specimens. METHODS:We enrolled 67...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-14-85
更新日期:2014-02-14 00:00:00
abstract:BACKGROUND:The swine influenza H1N1 first identified in Mexico, spread rapidly across the globe and is considered the fastest moving pandemic in history. The early phase of an outbreak, in which data is relatively scarce, presents scientific challenges on key issues such as: scale, severity and immunity which are funda...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-92
更新日期:2011-04-14 00:00:00
abstract:BACKGROUND:Chronic Q fever usually presents as endocarditis or endovascular infection. We investigated whether 18F-FDG PET/CT and echocardiography were able to detect the localization of infection. Also, the utility of the modified Duke criteria was assessed. METHODS:Fifty-two patients, who had an IgG titre of ≥ 1024...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-413
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical are...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1704-y
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile. METHODS:52 adult patients were enrolled in the study. B...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-137
更新日期:2007-11-22 00:00:00
abstract:BACKGROUND:Rotavirus (RV) vaccine was added to Yemen's childhood vaccination schedule in late 2012. We evaluated the effect of vaccination on the epidemiology of acute gastroenteritis (AGE) and the characteristics of circulating RV strains. METHODS:Surveillance data was obtained at two sentinel hospitals from 5,691 ch...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-015-1165-8
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:Studies report serious adherence problems among youth (individuals age 15-24 years of age) in Uganda. Recent growth in mobile phone ownership has highlighted the potential of using text-based interventions to improve antiretroviral treatment (ART) adherence among Ugandan youth. We piloted a randomized contro...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-020-4896-0
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:To ensure sustainable routine surveillance of mosquito vectors, simple, effective and ethically acceptable tools are required. As a part of that, we evaluated the efficiency of resting boxes baited with fresh and aging cattle urine for indoor and outdoor sampling of An. arabiensis in the lower Moshi rice irr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-172
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-2-22
更新日期:2002-10-04 00:00:00
abstract:BACKGROUND:Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine challenge. METHODS:We recruited healthy PM+ and PM- infants at birth. At...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-6
更新日期:2012-01-14 00:00:00
abstract::The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/1471-2334-14-S5-S1
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:In accordance with international guidance for tuberculosis (TB) prevention, the Tanzanian Ministry of Health recommends isoniazid preventive therapy (IPT) for children aged 12 months and older who are living with HIV. Concerns about tolerability, adherence, and potential mistreatment of undiagnosed TB with m...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05471-z
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic resistance in Africa is high with unclear information regarding the real magnitude. This systematic review and meta-analysis was conducted to investigate the mag...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-018-3099-4
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its relia...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-180
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:Specific land cover types and activities have been correlated with Trypanosoma brucei rhodesiense distributions, indicating the importance of landscape for epidemiological risk. However, methods proposed to identify specific areas with elevated epidemiological risk (i.e. where transmission is more likely to ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-316
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Neonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated with a focus of infection. This distinction is not well characterized. METHODS:All patients with neo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2574-7
更新日期:2017-07-03 00:00:00