Update on different aspects of HCV variability: focus on NS5B polymerase.

Abstract:

:The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The HCV NS5B gene encodes a polymerase, which is responsible for virus replication and is a potential target for the development of antiviral agents. Many studies for classification of HCV use a particular segment of the NS5B gene, in addition to other specific regions, and phylogenetic analysis. Actually, some nucleoside/nucleotide analogues and non-nucleoside inhibitors target NS5B protein. This review focuses on HCV variability, phylogenetic analysis and the role of NS5B in the virus-host interactions.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Marascio N,Torti C,Liberto M,Focà A

doi

10.1186/1471-2334-14-S5-S1

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

S1

issn

1471-2334

pii

1471-2334-14-S5-S1

journal_volume

14 Suppl 5

pub_type

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