Abstract:
BACKGROUND:In the pre-vaccine era, invasive disease with Haemophilus influenzae, type b (Hib) commonly presented with osteoarticular involvement. Haemophilus influenzae, type a (Hia) sepsis is a rare but emerging problem in recent years. Here, we report a case of sepsis with concomitant osteoarthritis due to Hia that was the presenting infectious disease manifestation of isolated asplenia in a young child. This unique observation adds to our understanding of sepsis and asplenia in children. CASE PRESENTATION:A five-year-old girl developed acute Hia bacteremia and sepsis. The patient developed arthritis shortly after onset of septic shock. Arthrocentesis was culture-negative, but given the difficulty differentiating between septic and reactive arthritis, prolonged antibiotic administration was provided for presumed osteoarticular infection, and the patient had an uneventful recovery. The finding of Howell-Jolly bodies on blood smear at the time of presentation prompted an evaluation that revealed isolated congenital asplenia. Evaluation for known genetic causes of asplenia was unrevealing. Investigation by the Minnesota Department of Health revealed an emergence of Hia infections over the past 5 years, particularly in children with an American Indian background. CONCLUSIONS:Hia is an important pathogen in the differential diagnosis of invasive bacterial infections in children and shares overlap in clinical presentation and pathogenesis with Hib. Invasive Hia disease can be a presenting manifestation of asplenia in children. Hia is an emerging pathogen in American Indian children.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Albrecht T,Poss K,Issaranggoon Na Ayuthaya S,Triden L,Schleiss KL,Schleiss MRdoi
10.1186/s12879-019-4572-4subject
Has Abstractpub_date
2019-11-08 00:00:00pages
947issue
1issn
1471-2334pii
10.1186/s12879-019-4572-4journal_volume
19pub_type
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05596-1
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:The spatial spread of H5N1 avian influenza, significant ongoing mutations, and long-term persistence of the virus in some geographic regions has had an enormous impact on the poultry industry and presents a serious threat to human health. METHODS:We applied phylogenetic analysis, geospatial techniques, and ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0770-x
更新日期:2015-02-13 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-07 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-364
更新日期:2014-07-03 00:00:00
abstract:BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...
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pub_type: 杂志文章
doi:10.1186/s12879-020-4775-8
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Data on sexually transmitted infections (STIs) in Saudi Arabia (SA) and other Islamic countries are limited. This study describes the results of a five-year surveillance for STIs in SA. METHODS:This is a case series descriptive study of all confirmed STIs diagnosed in SA from January, 1995 through December,...
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pub_type: 杂志文章
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更新日期:2006-01-10 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the correlation between the tuberculin skin test (TST) and in vitro interferon-gamma released assays (IGRAs) with risk factors for the spread of infection in smear positive pulmonary tuberculosis (TB) contacts. METHODS:We recruited prospective contacts with smear positive ...
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pub_type: 杂志文章
doi:10.1186/1471-2334-14-258
更新日期:2014-05-13 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-10 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/s12879-016-1793-7
更新日期:2016-08-26 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-016-2023-z
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In Ethiopia, measles case-based surveillance was introduced in 2004 as one strategy for measles control by laboratory confirmation of suspected cases. In this article, epidemiological distribution of laboratory-confirmed measles cases were reported from the Southern Nation Nationalities and Peoples Region (S...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2183-5
更新日期:2017-01-19 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1747-0
更新日期:2016-08-11 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-24
更新日期:2014-01-13 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-019-4633-8
更新日期:2019-11-27 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-018-3560-4
更新日期:2018-12-06 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-014-0636-7
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pub_type: 杂志文章
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更新日期:2011-09-16 00:00:00
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更新日期:2019-02-14 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-07 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2334-12-366
更新日期:2012-12-21 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1186/1471-2334-12-223
更新日期:2012-09-21 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-17 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2334-10-236
更新日期:2010-08-10 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2017-03-09 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-10-15 00:00:00