Abstract：
BACKGROUND:Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical impedance analysis (BIA), and mean change in body mass index (BMI) during and after tuberculosis treatment. METHODS:In a prospective cohort study of 717 adult patients, BMI and height-normalized indices of lean tissue (LMI) and fat mass (FMI) as measured by BIA were assessed at baseline, 3, 12, and 24 months. RESULTS:Men with wasting at baseline regained LMI at a greater rate than FMI (4.55 kg/m2 (95% confidence interval (CI): 1.26, 7.83 versus 3.16 (95% CI: 0.80, 5.52)) per month, respectively during initial tuberculosis therapy. In contrast, women with wasting regained FMI at greater rate than LMI (3.55 kg/m2 (95% CI: 0.40, 6.70) versus 2.07 (95% CI: -0.74, 4.88)), respectively. Men with wasting regained BMI at a rate of 6.45 kg/m2 (95% CI: 3.02, 9.87) in the first three months whereas women, had a rate of 3.30 kg/m2 (95% CI: -0.11, 6.72). There were minimal changes in body composition after month 3 and during months 12 to 24. CONCLUSION:Wasted tuberculosis patients regain weight with treatment but the type of gain differs by gender and patients may remain underweight after the initial phase of treatment.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Mupere E,Malone L,Zalwango S,Okwera A,Nsereko M,Tisch DJ,Parraga IM,Stein CM,Mugerwa R,Boom WH,Mayanja HK,Whalen CC,Tuberculosis Research Unit at Case Western Reserve University.doi
10.1186/1471-2334-14-24subject
Has Abstractpub_date
2014-01-13 00:00:00pages
24issn
1471-2334pii
1471-2334-14-24journal_volume
14pub_type
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