Abstract:
BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyrimethamine and quinine in severe acute malnourished children. Overall, efficacy of these treatments appeared to be reduced, attributed to lower immunity and for some antimalarials altered pharmacokinetic profiles and lower drug concentrations. However, similar research on the efficacy and pharmacokinetic profiles of artemisinin-combination therapies (ACTs) and especially artemether-lumefantrine in malnourished children is currently lacking. The main objective of this study is to assess whether artemether-lumefantrine is less efficacious in children suffering from severe acute malnutrition (SAM) compared to non-SAM children, and if so, to what extent this can be attributed to a sub-optimal pharmacokinetic profile. METHODS/DESIGN:In two sites, Ouelessebougou, Mali and Maradi, Niger, children with uncomplicated microscopically-confirmed P. falciparum malaria aged between 6 and 59 months will be enrolled. Two non-SAM children will be enrolled after the enrolment of each SAM case. Children with severe manifestations of malaria or complications of acute malnutrition needing intensive treatment will be excluded. Treatment intakes will be supervised and children will be followed-up for 42 days, according to WHO guidance for surveillance of antimalarial drug efficacy. Polymerase Chain Reaction genotyping will be used to distinguish recrudescence from re-infection. SAM children will also benefit from the national nutritional rehabilitation program. Outcomes will be compared between the SAM and non-SAM populations. The primary outcome will be adequate clinical and parasitological response at day 28 after PCR correction, estimated by Kaplan-Meier analysis. To assess the pharmacokinetic profile of lumefantrine, a sparse sampling approach will be used with randomized allocation of sampling times (5 per child). A total of 180 SAM children and 360 non-SAM children will be recruited during the 2013 and 2014 malaria seasons. DISCUSSION:This study will provide important information that is currently lacking on the effect of SAM on therapeutic efficacy and pharmacokinetic profile of artemether-lumefantrine. If it shows lower therapeutic efficacy and decreased lumefantrine concentrations, it would inform dose optimization studies in SAM children. TRIAL REGISTRATION:ClinicalTrials.gov: NCT01958905.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Denoeud-Ndam L,Dicko A,Baudin E,Guindo O,Grandesso F,Sagara I,Lasry E,Palma PP,Parra AM,Stepniewska K,Djimde AA,Barnes KI,Doumbo OK,Etard JFdoi
10.1186/s12879-015-0963-3subject
Has Abstractpub_date
2015-06-12 00:00:00pages
228issn
1471-2334pii
10.1186/s12879-015-0963-3journal_volume
15pub_type
临床试验,杂志文章,多中心研究abstract:BACKGROUND:In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS:The case definition was that a child with onychomadesis or transverse ridging (Beau's line) in fingernails and toenails without ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4560-8
更新日期:2019-11-26 00:00:00
abstract:BACKGROUND:In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs. METHODS:We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and mon...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-1-20
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Vibrio spp. are aquatic bacteria that are ubiquitous in warm estuarine and marine environments, of which 12 species are currently known to cause infections in humans. So far, only five human infections with V. harveyi have been reported. CASE PRESENTATION:A 26-year old patient was transferred to our center ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-020-4789-2
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected are unaware of their disease limiting prevention and early treatment options. The purpose of this co...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0854-7
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:BCG immunogenicity in infants differs between populations and these differences have been attributed to various factors. In this study, the influence of geographical location, season of birth, timing of vaccination, micronutrient status (zinc) and inflammatory status (C-reactive protein, CRP) were assessed. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-184
更新日期:2014-04-05 00:00:00
abstract:BACKGROUND:Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS). METHODS:This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-021-05771-y
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:HIV-related stigma always is major obstacles to an effective HIV response worldwide. The effect of HIV-related stigma on HIV prevention and treatment is particularly serious in China. This study was to examine stigma attitude towards people living with HIV/AIDS (PLWHA) among general individuals in Heilongjia...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2216-0
更新日期:2017-02-17 00:00:00
abstract:BACKGROUND:Globally, prison inmates are a high-risk population for tuberculosis (TB), but the specific drivers of disease and impact of mass screening interventions are poorly understood. METHODS:We performed a prospective cohort study to characterize the incidence and risk factors for tuberculosis infection and disea...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1868-5
更新日期:2016-10-03 00:00:00
abstract:BACKGROUND:Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medic...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-017-2445-2
更新日期:2017-05-18 00:00:00
abstract:BACKGROUND:Recent studies suggest HIV-1 inter-subtype differences in co-receptor usage. We examined the correlation between HIV-1 subtype and co-receptor usage among treatment-naïve HIV-1 subjects in Singapore. Additionally, we investigated whether the subtype co-receptor association was influenced by stage of infectio...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-90
更新日期:2013-02-19 00:00:00
abstract:BACKGROUND:Male partner HIV testing and counseling (HTC) is associated with enhanced uptake of prevention of mother-to-child HIV transmission (PMTCT), yet male HTC during pregnancy remains low. Identifying settings preferred by pregnant women and their male partners may improve male involvement in PMTCT. METHODS:Parti...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-015-1053-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS:We studied patients with...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/s12879-016-1896-1
更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because N. gonorrhoeae infections are not reportable in Germany, only limited data on disease epidemiolo...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-2944-9
更新日期:2018-01-17 00:00:00
abstract:BACKGROUND:Pertussis is a reported vaccine-preventable respiratory disease in China. Because the routine laboratory methods for diagnosis are not in use, the reported cases are mainly in infants with classical paroxysmal cough and the true incidence related to pertussis is most likely under estimated. In China, however...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-138
更新日期:2012-06-20 00:00:00
abstract:BACKGROUND:Necrotizing fasciitis (NF) is a rapidly progressive and life-threatening infection. This study aimed to investigate the clinical characteristics and mortality- associated factors in diabetic patients. METHODS:Detailed clinical information of 165 NF cases was retrospectively collected and analyzed in Nationa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1144-0
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:The optimal therapeutic strategies for patients presenting with advanced disease at HIV-1 diagnosis are as yet incompletely defined. METHODS:All patients presenting at two outpatient clinics in 2000-2009 with an AIDS-defining clinical condition or a CD4+ T cell count < 200/μL at HIV-1 diagnosis were analyze...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-341
更新日期:2011-12-14 00:00:00
abstract:BACKGROUND:Healthy condition and chronic diseases may be associated with microbiota composition and its properties. The prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofilm formation in patients with sarcoidosis was assayed. METHODS:Nasopharynx and sputum specimens wer...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1793-7
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its relia...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-180
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:Pertussis diagnosis may go unrecognized when other pathogens, such as respiratory syncytial virus (RSV) circulate. METHODS:A prospective cross-sectional study was conducted in Lima, Peru from January 2009 to September 2010. A total of 596 children under 5 years old admitted with clinical diagnoses of acute ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1287-z
更新日期:2015-12-02 00:00:00
abstract:BACKGROUND:Several highly pathogenic avian influenza (AI) outbreaks have been reported over the past decade. South Korea recently faced AI outbreaks whose economic impact was estimated to be 6.3 billion dollars, equivalent to nearly 50% of the profit generated by the poultry-related industries in 2008. In addition, AI ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-236
更新日期:2010-08-10 00:00:00
abstract:BACKGROUND:Chronic kidney disease, including end-stage renal disease, has been identified as a possible risk factor for primary septicemia and wound infection by Vibrio vulnificus. However, cases of severe septicemia, necrotizing fasciitis, and peritonitis caused by V. vulnificus in patients undergoing continuous ambul...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1163-x
更新日期:2015-10-14 00:00:00
abstract:BACKGROUND:A global pandemic mortality study found prominent regional mortality variations in 2009 for Influenza A(H1N1)pdm09. Our study attempts to identify factors that explain why the pandemic mortality burden was high in some countries and low in others. METHODS:As a starting point, we identified possible risk fac...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2730-0
更新日期:2017-09-25 00:00:00
abstract:BACKGROUND:Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, ga...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-018-3232-4
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:The live attenuated tetravalent dengue vaccine (CYD-TDV) is licensed using a 0-, 6- and 12-month schedule in dengue-endemic areas. An effective shorter schedule may provide more rapid, optimal protection of targeted populations during vaccine campaigns in dengue-endemic countries. We compared immune response...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-018-3389-x
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. Since clinical judgment is sometimes uncertain biomarkers could provide additional information likely to guide critical illness management. We evaluated the p...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1893-4
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:Healthcare-associated infections have become a public health problem, creating a new burden on medical care in hospitals. The emergence of multidrug-resistant bacteria poses a difficult task for physicians, who have limited therapeutic options. The dissemination of pathogens depends on "reservoirs", the diff...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3648-x
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:A decline in hemoglobin (Hb) concentration during antiviral therapy in chronic hepatitis C (CHC) is a serious side effect. It may compel to dose reduction or even termination of antiviral treatment. The activation of erythropoietin (EPO) synthesis as a physiological response to anemia and its relation to a g...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-503
更新日期:2014-09-17 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of complicated skin and skin structure infections (cSSSI). Patients with MRSA require different empiric treatment than those with non-MRSA infections, yet no accurate tools exist to aid in stratifying the risk for a MRSA cSSSI. We sought ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2334-12-154
更新日期:2012-07-11 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sample size. Hence this study aimed to estimate HBV seroprevalence using a large inpatient population ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4091-3
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Although there is a large increase in investment for tuberculosis control in Myanmar, there are few operational analyses to inform policies. Only 34% of nationally reported cases are from women. In this study, we investigate sex differences in tuberculosis diagnoses in Myanmar in order to identify potential ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1429-y
更新日期:2016-03-03 00:00:00