Abstract:
BACKGROUND:Recent studies suggest HIV-1 inter-subtype differences in co-receptor usage. We examined the correlation between HIV-1 subtype and co-receptor usage among treatment-naïve HIV-1 subjects in Singapore. Additionally, we investigated whether the subtype co-receptor association was influenced by stage of infection. METHODS:V3 sequences of HIV-1 envelope protein gp120 were obtained from 110 HIV treatment-naïve patients and genotypic co-receptor tropism determination was performed using Geno2pheno. Two false-positive rate (FPR) cut-offs, 10% and 5.75% were selected for tropism testing. RESULTS:Subtype assignment of viral strains from 110 HIV-infected individuals based on partial sequencing of HIV-1 pol, gp120 and gp41 were as follows: 27 subtype B, 64 CRF01_AE, 10 CRF51_01B, and 9 other subtypes. At FPR=10%, 10 (100%) CRF51_01B-infected subjects and 26 (40.6%) CRF01_AE-infected subjects had CXCR4-using virus, compared to 7 (25.9%) subtype B subjects and 1 (11.1%) CRF33_01B-infected subject (P < 0.001). At FPR=5.75%, 10 (100%) CRF51_01B-infected subjects and 20 (31.3%) CRF01_AE-infected subjects had CXCR4-using virus, compared to 4 (14.8%) subtype B and 1 (11.1%) CRF33_01B-infected subjects (P < 0.001). Among those with evidence of seroconversion within 2 years prior to study enrolment, 100% of CRF51_01B-infected subjects had CXCR4-using virus, independent of Geno2pheno FPR. CONCLUSION:CRF51_01B and CRF01_AE-infected individuals have higher prevalence of CXCR4-usage compared to subtype B infected individuals. Further studies examining these differences could help optimise the use of CCR5-antagonist in populations with these subtypes, and increase our understanding of HIV-1 biology.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Ng KY,Chew KK,Kaur P,Kwan JY,Khong WX,Lin L,Chua A,Tan MT,Quinn TC,Laeyendecker O,Leo YS,Ng OTdoi
10.1186/1471-2334-13-90subject
Has Abstractpub_date
2013-02-19 00:00:00pages
90issn
1471-2334pii
1471-2334-13-90journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Respiratory viral diagnosis of upper respiratory tract infections has largely developed through multiplex molecular techniques. Although the sensitivity of different types of upper respiratory tract samples seems to be correlated to the number of sampled cells, this link remains largely unexplored. METHODS:...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1730-9
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Estimates of Human Papillomavirus (HPV) prevalence in a population prior to and after HPV vaccine introduction are essential to evaluate the short-term impact of vaccination. METHODS:Between 2010 and 2012 we conducted a population-based cross-sectional study in Germany to determine HPV prevalence, genotype ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-87
更新日期:2014-02-19 00:00:00
abstract:BACKGROUND:To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey. METHODS:A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2334-11-337
更新日期:2011-12-12 00:00:00
abstract:BACKGROUND:Identification of the causative agents of invasive fungal infections (IFI) is critical for guiding antifungal therapy. Cultures remain negative in a substantial number of IFI cases. Accordingly, species identification from formalin fixed, paraffin embedded (FFPE) tissue specimens by molecular methods such as...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-202
更新日期:2011-07-26 00:00:00
abstract:BACKGROUND:There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1446-x
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:The current low access to virological testing to confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex, costly and require sophisticated laboratory infrastructure. Diagnostic manufacturers need guidance ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2770-5
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The parasite Entamoeba histolytica is the causal agent of amoebiasis, a worldwide emerging disease. Amebic brain abscess is a form of invasive amebiasis that is both rare and frequently lethal. This condition always begins with the infection of the colon by E. histolytica trophozoites, which subsequently tra...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05391-y
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Cellulitis, a frequent cause of admission of adult patients to medical wards, occasionally evolves to sepsis. In this study we analyze the factors related to sepsis development. METHODS:Prospective and observational study of 606 adult patients with cellulitis admitted to several Spanish hospitals. Comorbidi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4915-1
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyr...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12879-015-0963-3
更新日期:2015-06-12 00:00:00
abstract:BACKGROUND:Infection with carbapenem-resistant Acinetobacter baumannii has been associated with high morbidity and mortality in solid organ transplant recipients. The main objective of this study was to assess the influence of carbapenem resistance and other potential risk factors on the outcome of A. baumannii infecti...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-351
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Despite the widespread offer of free HIV testing in France, the proportion of people who have never been tested remains high. The objective of this study was to identify, in men and women separately, the various factors independently associated with no lifetime HIV testing. METHODS:We used multilevel logist...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1006-9
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS:Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identif...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2153-3
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Asplenic individuals are susceptible for overwhelming infection with Streptococcus pneumoniae, carrying a high mortality. Although Toll-like receptor (TLR)-2 is considered the major receptor for Gram-positive bacteria in innate immunity, it does not play a major role in host defense against pneumococcal pneu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-139
更新日期:2012-06-21 00:00:00
abstract:BACKGROUND:To determine the prevalence of carriage of respiratory bacterial pathogens, and the risk factors for and serotype distribution of pneumococcal carriage in an Australian Aboriginal population. METHODS:Surveys of nasopharyngeal carriage of Streptococcus pneumoniae, non-typeable Haemophilus influenzae, and Mor...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-304
更新日期:2010-10-23 00:00:00
abstract:BACKGROUND:At the end of the 1970s, in Italy more than 2% of the general population was HBsAg carrier. In the late '70s and late '80s, two remarkable events might have impacted on HBV strains transmitted in North-East Italy: (a) the increased HBV incidence due to parenteral drugs between 1978 and 1982; (b) the preventi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4713-9
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control strategy, particularly in schools where viral transm...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-71
更新日期:2013-02-05 00:00:00
abstract:BACKGROUND:Anisakid nematodes (Anisakis spp. or Pseudoterranova spp.) usually infect gastric or intestinal walls, while they rarely infect in extra-gastrointestinal sites of human body. Generally, Anisakis spp. larvae are highly infected in fish intermediate hosts, whereas Pseudoterranova spp. larvae are very rarely in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3540-8
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Leprosy still remains an important public health problem for many parts of the world. An association of gangrene with leprosy is a rare one & can have a number of causative mechanisms. We present a case with Leprosy & gangrene with positive anti phopholipid antibody titers. CASE PRESENTATION:A 50-year-old n...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-74
更新日期:2005-09-21 00:00:00
abstract:BACKGROUND:Lassa fever has been a public health concern in the West African sub-region where it is endemic and a latent threat to the world at large. We investigated the trend in Lassa fever research using bibliometric approach. METHODS:We used the SCOPUS database employing "Lassa fever" as search descriptor. The most...
journal_title:BMC infectious diseases
pub_type: 历史文章,杂志文章
doi:10.1186/s12879-018-3526-6
更新日期:2018-12-10 00:00:00
abstract:BACKGROUND:The objective of this study was to explore effects of khat (Catha edulis) on outcome of rodent malaria infection and its anti-plasmodial activities on Plasmodium berghei ANKA (PbA). METHODS:Female Swiss albino mice were orally treated with crude khat (Catha edulis) extracts (100, 200 and 300 mg/kg) on a dai...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0911-2
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquitoes to increasing ITN coverage could allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this k...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-161
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Non-touch fittings have been reported to be susceptible for Pseudomonas aeruginosa accumulation. A number of factors may contribute to this, including the frequency of usage, duration of water stagnation, or presence of plastic materials. Programmable non-touch fittings are appearing which allow regular auto...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-402
更新日期:2013-08-30 00:00:00
abstract:BACKGROUND:Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. METHODS:A five-year cross-sectional study was conducted in a tertiary children's hospital in Zheji...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05030-6
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:Nosocomial infection diagnosis in the intensive care unit (ICU) remains a challenge. We compared routine measurements of procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC) and temperature in the detection of ICU-acquired infections. METHOD:Prospective observational cohort study in a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-159
更新日期:2013-04-02 00:00:00
abstract:BACKGROUND:Recently we developed and validated generic quality indicators that define 'appropriate antibiotic use' in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that with appropriate antibiotic use a reduction of 13% of length of hospital stay can be achieved. Our mai...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-015-0867-2
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:Malaria remains a major tropical vector-borne disease of immense public health concern owing to its debilitating effects in sub-Saharan Africa. Over the past 30 years, the high altitude areas in Eastern Africa have been reported to experience increased cases of malaria. Governments including that of the Repu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05158-5
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-015-0843-x
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Procalcitonin (PCT) has become a commonly used serum inflammatory marker. Our aim was to describe the kinetics and usefulness of serial post-operative PCT measurements to detect bacterial infection in a cohort of children immediately after pediatric liver transplantation (pLT). METHODS:We performed a retros...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2234-y
更新日期:2017-02-15 00:00:00
abstract:BACKGROUND:The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwide vaccine demands and manufacturing restrictions urge for more detailed dose sparing studies. The e...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-14-391
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Streptococcus pneumoniae (Pnc), nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are the most important bacterial pathogens associated with otitis media (OM). Previous studies have suggested that early upper respiratory tract (URT) bacterial carriage may increase risk of subsequent ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-366
更新日期:2012-12-21 00:00:00