Abstract:
BACKGROUND:The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwide vaccine demands and manufacturing restrictions urge for more detailed dose sparing studies. The establishment of complementary biomarkers in addition to PRNT and Viremia could support a secure decision-making regarding the use of 17DD YF vaccine subdoses. The present work aimed at comparing the serum chemokine and cytokine kinetics triggered by five subdoses of 17DD YF Vaccine. METHODS:Neutralizing antibody titers, viremia, cytokines and chemokines were tested on blood samples obtained from eligible primary vaccinees. RESULTS AND DISCUSSION:The results demonstrated that a fifty-fold lower dose of 17DD-YF vaccine (587 IU) is able to trigger similar immunogenicity, as evidenced by significant titers of anti-YF PRNT. However, only subdoses as low as 3,013 IU elicit viremia kinetics with an early peak at five days after primary vaccination equivalent to the current dose (27,476 IU), while other subdoses show a distinct, lower in magnitude and later peak at day 6 post-vaccination. Although the subdose of 587 IU is able to trigger equivalent kinetics of IL-8/CXCL-8 and MCP-1/CCL-2, only the subdose of 3,013 IU is able to trigger similar kinetics of MIG/CXCL-9, pro-inflammatory (TNF, IFN-γ and IL-2) and modulatory cytokines (IL-5 and IL-10). CONCLUSIONS:The analysis of serum biomarkers IFN-γ and IL-10, in association to PRNT and viremia, support the recommendation of use of a ten-fold lower subdose (3,013 IU) of 17DD-YF vaccine.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Campi-Azevedo AC,de Almeida Estevam P,Coelho-Dos-Reis JG,Peruhype-Magalhães V,Villela-Rezende G,Quaresma PF,Maia Mde L,Farias RH,Camacho LA,Freire Mda S,Galler R,Yamamura AM,Almeida LF,Lima SM,Nogueira RM,Silva Sá GR,Hokadoi
10.1186/1471-2334-14-391subject
Has Abstractpub_date
2014-07-15 00:00:00pages
391issn
1471-2334pii
1471-2334-14-391journal_volume
14pub_type
杂志文章,随机对照试验abstract:BACKGROUND:To determine the prevalence of carriage of respiratory bacterial pathogens, and the risk factors for and serotype distribution of pneumococcal carriage in an Australian Aboriginal population. METHODS:Surveys of nasopharyngeal carriage of Streptococcus pneumoniae, non-typeable Haemophilus influenzae, and Mor...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-304
更新日期:2010-10-23 00:00:00
abstract:BACKGROUND:Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-2-22
更新日期:2002-10-04 00:00:00
abstract:BACKGROUND:Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The purpose of this study was to assess the association between MC and genital HPV infection in men in a l...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-18
更新日期:2013-01-17 00:00:00
abstract:BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1285-1
更新日期:2015-12-03 00:00:00
abstract:BACKGROUND:Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan. MET...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-262
更新日期:2012-10-18 00:00:00
abstract::Hepatitis C virus infection (HCV) is one of the most pressing health emergencies in the world with a global prevalence of about 170 million people chronically infected worldwide. In Europe, Italy has the highest HCV prevalence (3 - 4.4%) with peaks of 12.6 - 26% in Southern regions and the major islands. In Italy HCV ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/1471-2334-12-S2-S5
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Salmonella enterica, serovar Typhi (S. Typhi), a causative agent of enteric fever (typhoid fever), predominately affects populations in developing regions with poor access to clean food and water. In addition, travelers to these regions are at risk of exposure. METHODS:We report the epidemiological characte...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1159-6
更新日期:2015-10-14 00:00:00
abstract:INTRODUCTION:The World Health Organization recommends that countries conduct two phase evaluations of HIV rapid tests (RTs) in order to come up with the best algorithms. In this report, we present the first ever such evaluation in Uganda, involving both blood and oral based RTs. The role of weak positive (WP) bands on ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3001-4
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Globally, diarrhea is the leading cause of morbidity and mortality among less than 5 years old children and it contributes to the deaths of approximately one million children every year. In Ethiopia, diarrhea is the second cause of under-five mortality and morbidity. However, in the study area, studies were ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4445-x
更新日期:2019-09-13 00:00:00
abstract:BACKGROUND:In Finland, the annual number of MRSA notifications to the National Infectious Disease Register (NIDR) has constantly increased since 1995, and molecular typing has revealed numerous outbreak isolates of MRSA. We analyzed the data on MRSA notifications of the NIDR, and MRSA isolates were identified mainly by...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-94
更新日期:2007-08-14 00:00:00
abstract:BACKGROUND:Ureaplasma urealyticum is a fastidious bacteria which lacks a cell wall. Extragenital infections are rare in immunocompetent adults. There are few literature reports of perinephric abscess. We present a case of non-resolving multifocal "culture-negative" abscesses in a hypogammaglobulinemic adult female due ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4771-z
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:In accordance with international guidance for tuberculosis (TB) prevention, the Tanzanian Ministry of Health recommends isoniazid preventive therapy (IPT) for children aged 12 months and older who are living with HIV. Concerns about tolerability, adherence, and potential mistreatment of undiagnosed TB with m...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05471-z
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Despite the availability of antiretroviral therapy (ART), suboptimal treatment outcomes have been observed among HIV-seropositive illicit drug users. As there is an urgent need to improve responses to antiretroviral therapy among this population, we undertook this study to evaluate the role of physician expe...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-22
更新日期:2012-01-25 00:00:00
abstract:BACKGROUND:Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS:Latency of TB infection among Vietnamese healthcare workers was es...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1911-6
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were offered LTBI treatment, after active TB was excluded. In 2010, BCH...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-360
更新日期:2012-12-19 00:00:00
abstract:BACKGROUND:Drug resistant organisms pose an increasing threat to the successful treatment of common infections. Understanding colonization patterns of these bacteria is important for effective antibiotic treatment and infection control guidelines. METHODS:A prospective observational study was performed to determine th...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-298
更新日期:2014-06-02 00:00:00
abstract:BACKGROUND:HIV-associated neurocognitive disorder (HAND) remains prevalent in the era of combination antiretroviral therapy (cART). The prevalence of HAND in Hong Kong is not known. METHODS:Between 2013 and 2015, 98 treatment-naïve HIV-1-infected individuals were referred to and screened by the AIDS Clinical Service, ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3784-y
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen causing female genital tract infection throughout the world. Reinfection with the same serovar, as well as multiple infections with different serovars, occurs in humans. Using a murine model of female C. trachomatis genital trac...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-105
更新日期:2005-11-17 00:00:00
abstract:BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4775-8
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Bedaquiline was recently introduced into World Health Organization (WHO)-recommended regimens for treatment of drug resistant tuberculosis. There is limited data on the long-term safety of bedaquiline. Because bedaquiline prolongs the QT interval, there are concerns regarding cardiovascular safety. The Weste...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4197-7
更新日期:2019-06-20 00:00:00
abstract:BACKGROUND:Mutations in the basic core promoter (BCP) and its adjacent precore (preC) region in HBV genome are common in chronic hepatitis B patients. However, the patterns of mutation combinations in these two regions during chronic infection are less understood. This study focused on single base mutations in BCP and ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-271
更新日期:2010-09-16 00:00:00
abstract:BACKGROUND:In intensive care unit (ICU), infection and colonization by resistant Gram-negative bacteria increase costs, length of stay and mortality. Extended-spectrum beta-lactamase--producing Enterobacteriaceae (ESBL-E) is a group of pathogens increasingly encountered in ICU setting. Conditions that promote ESBL-E ac...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1489-z
更新日期:2016-04-13 00:00:00
abstract:UNLABELLED:world has not faced a severe pandemic for decades, except the rather mild H1N1 one in 2009, pandemic influenza models are inherently hypothetical and validation is, thus, difficult. We aim at reconstructing a recent seasonal influenza epidemic that occurred in Switzerland and deem this to be a promising vali...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-115
更新日期:2011-05-09 00:00:00
abstract:BACKGROUND:A novel Ehrlichia, closely related to Ehrlichia ruminantium, was recently discovered from Panola Mountain State Park, GA, USA. We conducted a study to determine if this agent was recently introduced into the United States. METHODS:We developed a sensitive PCR assay based on the conserved gltA (citrate synth...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-54
更新日期:2008-04-23 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) has endorsed the next-generation Xpert MTB/RIF Ultra (Ultra) cartridge, and Uganda is currently transitioning from the older generation Xpert MTB/RIF (Xpert) cartridge to Ultra as the initial diagnostic test for pulmonary tuberculosis (TB). We assessed the diagnostic accur...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05727-8
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China. METHODS:Severe EV-A71 or CV-A16 caused HFMD children admitted to the Xinh...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3878-6
更新日期:2019-03-27 00:00:00
abstract:BACKGROUND:Hepatocellular Carcinoma (HCC) is one of the commonest cancers in Central Africa, a region with the unusual peculiarity to be hyperendemic for infections with Hepatitis B, C and D viruses. However, data estimating the respective proportions of HCC cases attributable to these viruses are still limited in this...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1992-2
更新日期:2016-11-07 00:00:00
abstract:BACKGROUND:The presence of diabetes mellitus increases the risk of several severe infections, but data on its effect on treatment outcomes in patients with nosocomial pneumonia (NP) caused by methicillin-resistant Staphylococcus aureus (MRSA) are limited. METHODS:We retrospectively analyzed data from a double-blind, r...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-016-1779-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:To better understand potential transmission risks from contact with the body fluids of children, we monitored the presence and amount of CMV shedding over time in healthy CMV-seropositive children. METHODS:Through screening we identified 36 children from the Atlanta, Georgia area who were CMV-seropositive, ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0569-1
更新日期:2014-11-13 00:00:00
abstract:BACKGROUND:While several studies have assessed the associations between biological factors and tuberculosis (TB) transmission, our understanding of the associations between TB transmission and social and economic factors remains incomplete. We aimed to explore associations between community TB transmission and socio-ec...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-4828-z
更新日期:2020-02-10 00:00:00