Phylogeny and phylodinamic of Hepatitis C in Italy.

Abstract:

:Hepatitis C virus infection (HCV) is one of the most pressing health emergencies in the world with a global prevalence of about 170 million people chronically infected worldwide. In Europe, Italy has the highest HCV prevalence (3 - 4.4%) with peaks of 12.6 - 26% in Southern regions and the major islands. In Italy HCV genotype 1b prevails, and genotype 4 is mainly found in the south of the country where the prevalence is particularly high in regions such as Calabria.Phylogenetics analysis is a molecular tool widely used to study rapidly-evolving RNA viruses that establish chronic infections such as HCV. Searching the scientific literature, it was found that thirty-nine genetic studies on HCV genotypes have been carried out in Italy between 1997 to 2012 years. However, phylogenetic analysis was performed only in fourteen out of thirty-nine HCV studies (36%) considered. Monitoring the genetic evolution of HCV is an essential step to control the local as well as global HCV epidemic and to develop efficient preventive and therapeutic strategies.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Ciccozzi M,Lo Presti A,Ciccaglione AR,Zehender G,Ciotti M

doi

10.1186/1471-2334-12-S2-S5

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

S5

issn

1471-2334

pii

1471-2334-12-S2-S5

journal_volume

12 Suppl 2

pub_type

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