Abstract:
BACKGROUND:The presence of diabetes mellitus increases the risk of several severe infections, but data on its effect on treatment outcomes in patients with nosocomial pneumonia (NP) caused by methicillin-resistant Staphylococcus aureus (MRSA) are limited. METHODS:We retrospectively analyzed data from a double-blind, randomized, multi-center, international clinical trial of culture-confirmed MRSA NP that compared treatment with linezolid to vancomycin. Specifically, we evaluated the clinical and microbiologic outcomes of patients with and without diabetes in the modified intent to treat population at end-of-treatment (EOT) and end-of-study (EOS, 7-30 days post-EOT). RESULTS:Among 448 enrolled patients 183 (40.8 %) had diabetes mellitus, 87 (47.5 %) of whom received linezolid and 96 (52.5 %) vancomycin. Baseline demographic and clinical characteristics were similar for the two treatment groups. Clinical success rates at EOS were 57.6 % with linezolid and 39.3 % with vancomycin, while microbiological success rates were 58.9 % with linezolid and 41.1 % with vancomycin. Among diabetic patients, rates of mortality and study drug-related adverse effects were similar between the treatment groups. Overall day 28 mortality rates were higher among diabetic patients compared to non-diabetic patients (23.5 vs 14.7 %, respectively: RD = 8.8 %, 95 % CI [1.4, 16.3]). CONCLUSIONS:Among diabetic patients with MRSA NP, treatment with linezolid, compared to vancomycin, was associated with higher clinical and microbiologic success rates, and comparable adverse event rates. TRIAL REGISTRATION:NCT00084266 .
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Equils O,da Costa C,Wible M,Lipsky BAdoi
10.1186/s12879-016-1779-5subject
Has Abstractpub_date
2016-09-06 00:00:00pages
476issn
1471-2334pii
10.1186/s12879-016-1779-5journal_volume
16pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:How HIV-1 enter into the eyes remains obscure. We postulated that HIV-1 Tat protein can alter the expression of specific tight-junction proteins and disturb the blood retinal barrier, and contributes to HIV trafficking into the eyes. This study is to determine the effects of HIV-1 Tat proteins on the barrier...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-77
更新日期:2008-06-06 00:00:00
abstract:BACKGROUND:The World Health Organization recommends TB infection control (TBIC) in health care facilities. In 2008, the Ministry of Health Uganda initiated efforts to implement TBIC by training of health care workers (HCWs). This study was carried out to assess knowledge and attitudes towards TBIC among HCWs. METHODS:...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1740-7
更新日期:2016-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-08 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1186/s12879-018-3334-z
更新日期:2018-08-22 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2019-06-26 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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更新日期:2008-05-16 00:00:00
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