Abstract：
BACKGROUND:Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The purpose of this study was to assess the association between MC and genital HPV infection in men in a large multinational study. METHODS:A total of 4072 healthy men ages 18-70 years were enrolled in a study conducted in Brazil, Mexico, and the United States. Enrollment samples combining exfoliated cells from the coronal sulcus, glans penis, shaft, and scrotum were analyzed for the presence and genotyping of HPV DNA by PCR and linear array methods. Prevalence ratios (PR) were used to estimate associations between MC and HPV detection adjusting for potential confounders. RESULTS:MC was not associated with overall prevalence of any HPV, oncogenic HPV types or unclassified HPV types. However, MC was negatively associated with non-oncogenic HPV infections (PR 0.85, 95% confident interval: 0.76-0.95), in particular for HPV types 11, 40, 61, 71, and 81. HPV 16, 51, 62, and 84 were the most frequently identified genotypes regardless of MC status. CONCLUSIONS:This study shows no overall association between MC and genital HPV infections in men, except for certain non-oncogenic HPV types for which a weak association was found. However, the lack of association with MC might be due to the lack of anatomic site specific HPV data, for example the glans penis, the area expected to be most likely protected by MC.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Albero G,Villa LL,Lazcano-Ponce E,Fulp W,Papenfuss MR,Nyitray AG,Lu B,Castellsagué X,Abrahamsen M,Smith D,Bosch FX,Salmerón J,Quiterio M,Giuliano ARdoi
10.1186/1471-2334-13-18subject
Has Abstractpub_date
2013-01-17 00:00:00pages
18issn
1471-2334pii
1471-2334-13-18journal_volume
13pub_type
杂志文章abstract：BACKGROUND:HIV affects the central nervous system resulting in HIV associated neurocognitive impairment (NCI) in approximately 50% of people living with HIV. It typically affects memory, learning, working memory, fine motor skills, speed of information processing, verbal fluency and executive functioning cognitive doma...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05090-8
更新日期：2020-05-29 00:00:00
abstract：BACKGROUND:The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two consecutive VL ≥1000 copies/mL (at...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12879-018-2979-y
更新日期：2018-02-12 00:00:00
abstract：BACKGROUND:Almost half the world's population is infected with Helicobacter pylori (H. pylori) with the highest reported prevalence from Africa. This infection is associated with several morbid gastrointestinal conditions. Understanding the trends in seroprevalence and the factors associated with H. pylori seropositivi...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-3677-0
更新日期：2019-01-08 00:00:00
abstract：BACKGROUND:Many people have multiple infections at the same time, but the combined contribution of those infections to disease-related mortality is unknown. Registered causes of death offer a unique opportunity to study associations between multiple infections. METHODS:We analysed over 900,000 death certificates that ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1118-2
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown to be the major causes for INH resistance, while the dynamic change of mutations conferring INH resistance among MTB strains during the pa...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4333-4
更新日期：2019-08-05 00:00:00
abstract：BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/s12879-015-0843-x
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:High blood levels of soluble urokinase Plasminogen Activator Receptor (suPAR) are associated with poor outcomes in human immunodeficiency-1 (HIV-1) infected individuals. Research on the clinical value of suPAR in HIV-1 infection led to the development of the suPARnostic(R) assay for commercial use in 2006. T...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-7-134
更新日期：2007-11-16 00:00:00
abstract：BACKGROUND:Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3455-4
更新日期：2018-11-06 00:00:00
abstract：BACKGROUND:In intensive care unit (ICU), infection and colonization by resistant Gram-negative bacteria increase costs, length of stay and mortality. Extended-spectrum beta-lactamase--producing Enterobacteriaceae (ESBL-E) is a group of pathogens increasingly encountered in ICU setting. Conditions that promote ESBL-E ac...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1489-z
更新日期：2016-04-13 00:00:00
abstract：BACKGROUND:Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT) in critically ill immunocompromised patients. METHODS:This prospective, observational study included patients with suspected sepsis. Patients were...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-11-224
更新日期：2011-08-24 00:00:00
abstract：BACKGROUND:Rilpivirine is safe and effective in HIV-naïve patients with low baseline HIV-RNA or in switch strategy. It offers the advantages of few drug-drug interactions and a favourable toxicity profile. We aimed to determine the reasons for prescribing the rilpivirine (RPV)/tenofovir disoproxil (TDF)/emtricitabine (...
journal_title：BMC infectious diseases
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1186/s12879-017-2579-2
更新日期：2017-07-06 00:00:00
abstract：BACKGROUND:Myocarditis can develop as a complication of various infections and is most commonly linked to enterovirus infections. Myocarditis is rarely associated with bacterial infections; salmonellosis and shigellosis have been the most frequently reported bacterial cause. We report a case of myocarditis related to C...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-3-16
更新日期：2003-07-17 00:00:00
abstract：BACKGROUND:Acute respiratory tract infections (ARTI) are an important public health problem. Improved identification of risk factors might enable targeted intervention. Therefore we carried out a case-control study with the aim of identifying environmental risk factors for ARTI consultations in the Dutch general popula...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-7-35
更新日期：2007-04-27 00:00:00
abstract：BACKGROUND:The different laboratory methods used in the diagnosis of congenital toxoplasmosis have variable sensitivity and specificity. There is no evidence to prove that maternal treatment reduces the risk of fetal infection. The purpose of this study was to assess methods for the confirmation of congenital toxoplasm...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-349
更新日期：2014-06-24 00:00:00
abstract：BACKGROUND:Adjustment of immunosuppression is the main therapy for BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) after kidney transplantation (KT). Studies of BKPyV-specific T cell immune response are scarce. Here, we investigated BKPyV-specific T cell immunity in KT recipients diagnosed with BKPyVAN. METHO...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4615-x
更新日期：2019-11-19 00:00:00
abstract：BACKGROUND:Plasmodium falciparum malaria, is a major health problem in forested tribal belt of central India. Rapid and accurate methods are needed for the diagnosis of P. falciparum. We performed a blinded evaluation of the recently introduced Determine trade mark malaria pf test (Abbott, Laboratories, Japan) compared...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-1-10
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Contact surveys and diaries have conventionally been used to measure contact networks in different settings for elucidating infectious disease transmission dynamics of respiratory infections. More recently, technological advances have permitted the use of wireless sensor devices, which can be worn by individ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-136
更新日期：2014-03-10 00:00:00
abstract：BACKGROUND:Molecular diagnostics have emerged as an efficient and feasible alternative for broad detection of pathogens in faeces. However, collection of stool samples is often impractical in both clinical work and in epidemiology studies. The aim of this study was to investigate the diagnostic performance of rectal sw...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-447
更新日期：2013-09-27 00:00:00
abstract：BACKGROUND:Viral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-014-0630-0
更新日期：2014-11-26 00:00:00
abstract：BACKGROUND:Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) clones are a global concern due to their resistance and increased virulence and their ability to cause infections both hospitalized patients and healthy people in the community. Here, we characterize 32 isolates of a new CG-MRSA clone. ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2193-3
更新日期：2017-01-31 00:00:00
abstract：BACKGROUND:Recent evidence indicates that Gram-negative bacterial pathogens, the most common of which are Pseudomonas spp., Enterobacteriaceae, and Acinetobacter baumannii, are frequent causes of hospital-acquired infections. This study aims to evaluate the in vitro activity of doripenem and comparator carbapenem antib...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-12-42
更新日期：2012-02-16 00:00:00
abstract：BACKGROUND:American trypanosomiasis is a major disease and public health issue, caused by the protozoan parasite Trypanosoma cruzi. The prevalence of T. cruzi has not been fully documented, and there are few reports of this issue in Nuevo Leon. The aim of this study was to update the seroprevalence rate of T. cruzi inf...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-117
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determining regions of M. genitalium in Johannesburg, South Africa, and ascertained their association wit...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-3797-6
更新日期：2019-02-13 00:00:00
abstract：BACKGROUND:The effects of helminth co-infection on malaria in humans remain uncertain. This study aimed to evaluate the nature of association of intestinal helminths with prevalence and clinical outcomes of Plasmodium infection. METHODS:A cross-sectional study involving 1,065 malaria suspected febrile patients was con...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-12-291
更新日期：2012-11-09 00:00:00
abstract：BACKGROUND:A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. CASE PRESENTATION:The patient presented with 1 week of weakness, dyspnea, and ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05439-z
更新日期：2020-09-29 00:00:00
abstract：BACKGROUND:Neonatal sepsis is one of the major causes of death during the first month of life and early empirical treatment with injectable antibiotics is a life-saving intervention. Adherence to World Health Organisation guidelines on first line antibiotics is crucial to mitigate the risks of increased antimicrobial r...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05361-4
更新日期：2020-09-10 00:00:00
abstract：BACKGROUND:Rotavirus (RV) vaccine was added to Yemen's childhood vaccination schedule in late 2012. We evaluated the effect of vaccination on the epidemiology of acute gastroenteritis (AGE) and the characteristics of circulating RV strains. METHODS:Surveillance data was obtained at two sentinel hospitals from 5,691 ch...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/s12879-015-1165-8
更新日期：2015-10-13 00:00:00
abstract：BACKGROUND:People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target post-tuberculosis screening and care. METHODS:We enrolled 500 patients with smear-positive pulmonar...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05515-4
更新日期：2020-10-23 00:00:00
abstract：BACKGROUND:Data on sexually transmitted infections (STIs) in Saudi Arabia (SA) and other Islamic countries are limited. This study describes the results of a five-year surveillance for STIs in SA. METHODS:This is a case series descriptive study of all confirmed STIs diagnosed in SA from January, 1995 through December,...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-6-3
更新日期：2006-01-10 00:00:00
abstract：BACKGROUND:Tuberculosis (TB) continues to be a public health challenge in Saudi Arabia, particularly for the elderly. This study was conducted to estimate mortality per 1000 person-year among TB and resistant TB cases and to identifying factors associated with mortality. METHODS:This is a retrospective cohort study of...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4063-7
更新日期：2019-05-16 00:00:00
