Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China.

Abstract:

BACKGROUND:Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China. METHODS:Severe EV-A71 or CV-A16 caused HFMD children admitted to the Xinhua Hospital from January 2014 and December 2016, were recruited retrospectively to the study. Symptoms and findings at the time of hospitalization, laboratory tests, treatments, length of stay and residual findings at discharge were systematically recorded and analyzed. RESULTS:Of 19,995 children visited clinic service with probable HFMD, 574 children (2.87%) were admitted, 234 children (40.76%) were confirmed with EV-A71 (90/574) or CV-A16 (144/574) disease. Most (91.02%) of the patients were under 5 years. Initial clinical symptoms of EV-A71 and CV-A16 cases were: fever > 39 °C in 81 (90%) and 119 (82.63%), vomiting in 31 (34.44%) and 28 (19.44%), myoclonic twitching in 19 (21.11%) and 11(7.64%), startle in 21 (23.33%) and 20 (13.69%), respectively. Serum levels of interleukin-1β (IL-1β), IL-2, IL-6, IL-8, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) were significantly upregulated in severe HFMD subjects. Forty-seven children (20.08%) treated with intravenous gamma globulin (IVIG) showed decreased duration of illness episodes. All children were discharged without complications. CONCLUSIONS:EV-A71 and CV-A16 accounted 40.76% of admitted HFMD during 2014 to 2016 in Xinhua Hospital. IVIG appeared to be beneficial in shortening the duration of illness episodes of severe HFMD.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Cai K,Wang Y,Guo Z,Yu H,Li H,Zhang L,Xu S,Zhang Q

doi

10.1186/s12879-019-3878-6

subject

Has Abstract

pub_date

2019-03-27 00:00:00

pages

285

issue

1

issn

1471-2334

pii

10.1186/s12879-019-3878-6

journal_volume

19

pub_type

杂志文章
  • Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients.

    abstract:BACKGROUND:High seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-375

    authors: Toan NL,Sy BT,Song le H,Luong HV,Binh NT,Binh VQ,Kandolf R,Velavan TP,Kremsner PG,Bock CT

    更新日期:2013-08-15 00:00:00

  • Mitigating effects of vaccination on influenza outbreaks given constraints in stockpile size and daily administration capacity.

    abstract:BACKGROUND:Influenza viruses are a major cause of morbidity and mortality worldwide. Vaccination remains a powerful tool for preventing or mitigating influenza outbreaks. Yet, vaccine supplies and daily administration capacities are limited, even in developed countries. Understanding how such constraints can alter the ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-207

    authors: Cruz-Aponte M,McKiernan EC,Herrera-Valdez MA

    更新日期:2011-08-01 00:00:00

  • Prevalence of multidrug-resistant organisms in refugee patients, medical tourists and domestic patients admitted to a German university hospital.

    abstract:BACKGROUND:Patients with contact to healthcare-system in high-prevalence countries (HPC) and refugee patients in hospital settings (REF) have previously been identified to be at risk of carrying multidrug-resistant organisms (MDRO). Comparative studies addressing the epidemiology of MDRO in patients transferred from ho...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2105-y

    authors: Reinheimer C,Kempf VA,Jozsa K,Wichelhaus TA,Hogardt M,O'Rourke F,Brandt C

    更新日期:2017-01-05 00:00:00

  • Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies.

    abstract:BACKGROUND:Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes of patients with hematologic malignancy and IA who were treated with voriconazole using the diagnost...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3584-9

    authors: Dib RW,Hachem RY,Chaftari AM,Ghaly F,Jiang Y,Raad I

    更新日期:2018-12-13 00:00:00

  • Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study.

    abstract:BACKGROUND:Rilpivirine is safe and effective in HIV-naïve patients with low baseline HIV-RNA or in switch strategy. It offers the advantages of few drug-drug interactions and a favourable toxicity profile. We aimed to determine the reasons for prescribing the rilpivirine (RPV)/tenofovir disoproxil (TDF)/emtricitabine (...

    journal_title:BMC infectious diseases

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/s12879-017-2579-2

    authors: Sculier D,Gayet-Ageron A,Battegay M,Cavassini M,Fehr J,Hirzel C,Schmid P,Bernasconi E,Calmy A,Swiss HIV Cohort Study.

    更新日期:2017-07-06 00:00:00

  • Safety of poly-L-lactic acid (New-Fill®) in the treatment of facial lipoatrophy: a large observational study among HIV-positive patients.

    abstract:BACKGROUND:Facial lipoatrophy is a frequently reported condition associated with use of antiretroviral (ARV) drugs. Poly-L-lactic acid (PLLA) acid has been used to correct facial lipoatrophy in people with HIV since 2004 both in Europe and the United States. The objective of this study was to establish, in real life co...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-14-474

    authors: Duracinsky M,Leclercq P,Herrmann S,Christen MO,Dolivo M,Goujard C,Chassany O

    更新日期:2014-09-01 00:00:00

  • Is aging raw cattle urine efficient for sampling Anopheles arabiensis Patton?

    abstract:BACKGROUND:To ensure sustainable routine surveillance of mosquito vectors, simple, effective and ethically acceptable tools are required. As a part of that, we evaluated the efficiency of resting boxes baited with fresh and aging cattle urine for indoor and outdoor sampling of An. arabiensis in the lower Moshi rice irr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-172

    authors: Mahande AM,Mwang'onde BJ,Msangi S,Kimaro E,Mnyone LL,Mazigo HD,Mahande MJ,Kweka EJ

    更新日期:2010-06-15 00:00:00

  • Correction to: A systematic review of necrotising fasciitis in children from its first description in 1930 to 2018.

    abstract::After publication of the original article [1], we were notified that two of the author names were incorrectly displayed in the pdf version of the paper, while one other name was incorrectly tagged in the XML version. ...

    journal_title:BMC infectious diseases

    pub_type: 已发布勘误

    doi:10.1186/s12879-019-4003-6

    authors: Schröder A,Gerin A,Firth GB,Hoffmann KS,Grieve A,Oetzmann von Sochaczewski C

    更新日期:2019-05-27 00:00:00

  • Infection characteristics and treatment of Staphylococcus aureus bacteraemia at a tertiary children's hospital.

    abstract:BACKGROUND:Staphylococcus aureus bacteraemia (SAB) causes considerable morbidity and mortality in children. Despite this, its epidemiology and risk factors are poorly understood, with minimal paediatric clinical trial data available to guide clinicians in management. We conducted a pilot study to characterise SAB and v...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3312-5

    authors: Munro APS,Blyth CC,Campbell AJ,Bowen AC

    更新日期:2018-08-10 00:00:00

  • Study on age-dependent pre-existing 2009 pandemic influenza virus T and B cell responses from Chinese population.

    abstract:BACKGROUND:The outbreak of the 2009 H1N1 influenza pandemic (H1N1pdm) affected thousands of people in Mexico and the United States, and spread rapidly throughout the world from April 2009 to July 2010. To explore the age-specific prevalence of seroprotection against H1N1pdm infection, we estimated pre-existing humoral ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2215-1

    authors: Lv J,Ren ZY,Zhang YY,Liu YE,Gao J,Yao K,Feng D,Li ZY,Feng X,Liu YX,Jia N

    更新日期:2017-02-10 00:00:00

  • Role of MIRU-VNTR and spoligotyping in assessing the genetic diversity of Mycobacterium tuberculosis in Henan Province, China.

    abstract:BACKGROUND:Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycobacterium tuberculosis (MTB) has been investigated in many regions, there have been only a few stu...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3351-y

    authors: Shi J,Zheng D,Zhu Y,Ma X,Wang S,Li H,Xing J

    更新日期:2018-09-03 00:00:00

  • Predictors of loss to follow up among adult clients attending antiretroviral treatment at Karamara general hospital, Jigjiga town, Eastern Ethiopia, 2015: a retrospective cohort study.

    abstract:BACKGROUND:Retention in care and adherence to the treatment is very important for the success of the program while access for treatment is being scaled up. Without more precise data about the rate of loss to follow up as well the characteristics of those who disengage from the treatment appropriate interventions to inc...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3188-4

    authors: Seifu W,Ali W,Meresa B

    更新日期:2018-06-18 00:00:00

  • Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women.

    abstract:BACKGROUND:The presence of hydrogen peroxide (H(2)O(2)) producing Lactobacillus in the vagina may play a role in controlling genital HIV-1 shedding. Sensitive molecular methods improve our ability to characterize the vaginal microbiota; however, they cannot characterize phenotype. We assessed the concordance of H(2)O(2...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-188

    authors: Balkus JE,Mitchell C,Agnew K,Liu C,Fiedler T,Cohn SE,Luque A,Coombs R,Fredricks DN,Hitti J

    更新日期:2012-08-13 00:00:00

  • Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA.

    abstract:BACKGROUND:Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2667-3

    authors: Yilmaz H,Karakullukcu A,Turan N,Cizmecigil UY,Yilmaz A,Ozkul AA,Aydin O,Gunduz A,Mete M,Zeyrek FY,Kirazoglu TT,Richt JA,Kocazeybek B

    更新日期:2017-08-11 00:00:00

  • Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada.

    abstract:BACKGROUND:Human Parainfluenza Virus (hPIV) causes severe respiratory illness in infants and adults. Our study describes the association of hPIV1-4 with bronchiolitis, croup, and pneumonia using retrospective laboratory, administrative and public health data. Due to issues including the historic lack of hPIV4 in some c...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1748-z

    authors: Fathima S,Simmonds K,Invik J,Scott AN,Drews S

    更新日期:2016-08-11 00:00:00

  • Primary cutaneous infection due to Microascus cirrosus: a case report.

    abstract:BACKGROUND:Microascus cirrosus, the teleomorph of Scopulariopsis spp., is a saprobic species with a worldwide distribution and rarely causes human infection. In the present paper, we present the first case of primary cutaneous M. cirrosus infection in a Chinese female. CASE PRESENTATION:A 17-year-old female presented ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3535-5

    authors: Gao L,Chen J,Gao D,Li M

    更新日期:2018-12-03 00:00:00

  • Severe falciparum malaria complicated by prolonged haemolysis and rhinomaxillary mucormycosis after parasite clearance: a case report.

    abstract:BACKGROUND:Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mu...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1285-1

    authors: Plewes K,Maude RJ,Ghose A,Dondorp AM

    更新日期:2015-12-03 00:00:00

  • Multifocal tuberculosis-associated immune reconstitution inflammatory syndrome - a case report of a complicated scenario.

    abstract:BACKGROUND:Tuberculosis (TB)-associated Immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response in TB patients with advanced human immunodeficiency virus coinfection, after antiretroviral therapy commencement. CASE PRESENTATION:We present a rare case of a 51-year-old woman living wit...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4182-1

    authors: Narendran G,Oliveira-de-Souza D,Vinhaes CL,Akrami K,Fukutani KF,Banu K,Chandrasekaran P,Ravichandran N,Sereti I,Swaminathan S,Andrade BB

    更新日期:2019-06-17 00:00:00

  • Tick-borne encephalitis (TBE) cases are not random: explaining trend, low- and high-frequency oscillations based on the Austrian TBE time series.

    abstract:BACKGROUND:Why human tick-borne encephalitis (TBE) cases differ from year to year, in some years more 100%, has not been clarified, yet. The cause of the increasing or decreasing trends is also controversial. Austria is the only country in Europe where a 40-year TBE time series and an official vaccine coverage time ser...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05156-7

    authors: Rubel F,Walter M,Vogelgesang JR,Brugger K

    更新日期:2020-06-26 00:00:00

  • Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study.

    abstract:BACKGROUND:Erysipelas is a common skin infection that is prone to recur. Recurrent erysipelas has a severe effect on the quality of life of patients. The present study aimed to investigate the risk factors of recurrent erysipelas in adult Chinese patients. METHODS:A total of 428 Chinese patients with erysipelas who me...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05710-3

    authors: Li A,Wang N,Ge L,Xin H,Li W

    更新日期:2021-01-07 00:00:00

  • Antibiotic susceptibility and genomic variations in Staphylococcus aureus associated with Skin and Soft Tissue Infection (SSTI) disease groups.

    abstract:BACKGROUND:Staphylococcus aureus is associated with human skin and soft tissue infections (SSTIs); however, the involvement of virulence factors in different clinical presentations is unclear. METHODS:We analyzed methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains from Taiwan to d...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1630-z

    authors: Changchien CH,Chen SW,Chen YY,Chu C

    更新日期:2016-06-10 00:00:00

  • Microdistribution of the resistance of malaria vectors to deltamethrin in the region of Plateau (southeastern Benin) in preparation for an assessment of the impact of resistance on the effectiveness of Long Lasting Insecticidal Nets (LLINs).

    abstract:BACKGROUND:This study aims to research two areas, one with a resistant and the other with a susceptible profile of An. gambiae to deltamethrin in the region of Plateau (southern Benin). In each area, eight localities were sought. Both areas were needed for the assessment of the impact of malaria vector resistance to py...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-103

    authors: Sovi A,Djègbè I,Soumanou L,Tokponnon F,Gnanguenon V,Azondékon R,Oké-Agbo F,Okè M,Adéchoubou A,Massougbodji A,Corbel V,Akogbéto M

    更新日期:2014-02-25 00:00:00

  • Pneumonia caused by extensive drug-resistant Acinetobacter baumannii among hospitalized patients: genetic relationships, risk factors and mortality.

    abstract:BACKGROUND:The clonal spread of multiple drug-resistant Acinetobacter baumannii is an emerging problem in China. We analysed the molecular epidemiology of Acinetobacter baumanni isolates at three teaching hospitals and investigated the risk factors, clinical features, and outcomes of hospital-acquired pneumonia caused ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2471-0

    authors: Li YJ,Pan CZ,Fang CQ,Zhao ZX,Chen HL,Guo PH,Zhao ZW

    更新日期:2017-05-30 00:00:00

  • Dynamic comparison between Daan real-time PCR and Cobas TaqMan for quantification of HBV DNA levels in patients with CHB.

    abstract:BACKGROUND:Hepatitis B virus (HBV) DNA levels are crucial for managing chronic hepatitis B (CHB). It was unclear whether Daan real-time polymerase chain reaction test (Daan test) or COBAS TaqMan HBV DNA Test (Cobas TaqMan) was superior in measuring different HBV DNA levels in clinical specimens. METHODS:We enrolled 67...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-14-85

    authors: Cai SH,Lv FF,Zhang YH,Jiang YG,Peng J

    更新日期:2014-02-14 00:00:00

  • Molecular epidemiology of Hepatitis B virus genotypes in Pakistan.

    abstract:BACKGROUND:Eight genotypes of Hepatitis B virus designated A-H, have been known but in Pakistan, no such data is available on the prevalent HBV genotypes. Therefore, the subject study was conducted to determine HBV genotypes in the indigenous Pakistani population. METHODS:A total of 690 individuals were enrolled for H...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-115

    authors: Alam MM,Zaidi SZ,Malik SA,Shaukat S,Naeem A,Sharif S,Angez M,Butt JA

    更新日期:2007-10-08 00:00:00

  • Wasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort study.

    abstract:BACKGROUND:Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical impedance analysis (BIA), and mean change in body mass index (BMI) during and after tuberculo...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-24

    authors: Mupere E,Malone L,Zalwango S,Okwera A,Nsereko M,Tisch DJ,Parraga IM,Stein CM,Mugerwa R,Boom WH,Mayanja HK,Whalen CC,Tuberculosis Research Unit at Case Western Reserve University.

    更新日期:2014-01-13 00:00:00

  • Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report.

    abstract:BACKGROUND:Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-330

    authors: Schoffelen T,den Broeder AA,Nabuurs-Franssen M,van Deuren M,Sprong T

    更新日期:2014-06-15 00:00:00

  • How should social mixing be measured: comparing web-based survey and sensor-based methods.

    abstract:BACKGROUND:Contact surveys and diaries have conventionally been used to measure contact networks in different settings for elucidating infectious disease transmission dynamics of respiratory infections. More recently, technological advances have permitted the use of wireless sensor devices, which can be worn by individ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-136

    authors: Smieszek T,Barclay VC,Seeni I,Rainey JJ,Gao H,Uzicanin A,Salathé M

    更新日期:2014-03-10 00:00:00

  • Spatial, temporal and genetic dynamics of highly pathogenic avian influenza A (H5N1) virus in China.

    abstract:BACKGROUND:The spatial spread of H5N1 avian influenza, significant ongoing mutations, and long-term persistence of the virus in some geographic regions has had an enormous impact on the poultry industry and presents a serious threat to human health. METHODS:We applied phylogenetic analysis, geospatial techniques, and ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0770-x

    authors: Tian H,Cui Y,Dong L,Zhou S,Li X,Huang S,Yang R,Xu B

    更新日期:2015-02-13 00:00:00

  • Whole-genome enrichment and sequencing of Chlamydia trachomatis directly from clinical samples.

    abstract:BACKGROUND:Chlamydia trachomatis is a pathogen of worldwide importance, causing more than 100 million cases of sexually transmitted infections annually. Whole-genome sequencing is a powerful high resolution tool that can be used to generate accurate data on bacterial population structure, phylogeography and mutations a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-014-0591-3

    authors: Christiansen MT,Brown AC,Kundu S,Tutill HJ,Williams R,Brown JR,Holdstock J,Holland MJ,Stevenson S,Dave J,Tong CY,Einer-Jensen K,Depledge DP,Breuer J

    更新日期:2014-11-12 00:00:00