Abstract:
BACKGROUND:Staphylococcus aureus is associated with human skin and soft tissue infections (SSTIs); however, the involvement of virulence factors in different clinical presentations is unclear. METHODS:We analyzed methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains from Taiwan to determine correlations among the clinical characteristics of SSTIs, antimicrobial susceptibility and virulence factors of S. aureus with specific genetic backgrounds. RESULTS:We identified 177 MRSA isolates and 130 MSSA isolates among the 307 SSTI-associated S. aureus isolates. Hospital-acquired (HA)- and community-acquired (CA)-MRSA isolates accounted for 61.6 % and 38.4 % of the isolates, respectively. Clinical presentations in SSTI patients differed significantly for the disease groups. Deep-seated MRSA infections presented with higher amputation rate than MSSA infections. MRSA isolates were all susceptible to linezolid, teicoplanin, and vancomycin, and >94 % of isolates were erythromycin- and clindamycin-resistant. Staphylococcal cassette chromosome (SCCmec) types IV, V, and VII were the most frequent in the CA-MRSA group (n = 68); types III, IV and V were the most frequent in the HA-MRSA group (n = 109). Panton-Valentine leukocidin (PVL) genes were significantly more frequent in CA-MRSA strains (75.0 %) than in HA-MRSA (33.0 %) and MSSA (24.6 %) and were found in 66.7 % (74/111) strains isolated from the abscess group. Exfoliatin A genes were more common in catheter-related exit-site MSSA infections (37.5 %) compared with other MSSA disease groups (P < 0.05). Exfoliatin B and superantigen exotoxin genes were uncommon in all SSTI disease types. Pulsotypes A (ST239), C, and D (ST59) were the predominant MRSA genotypes in deep-seated infections. CONCLUSIONS:If not treated appropriately, deep-seated MRSA-associated infections present with higher amputation rates than deep-seated MSSA-associated infections. PVL-positive MRSA strains caused more frequently pus-forming lesions and less bacteremia and invasive diseases. Methods for discriminating CA-MRSA from HA-MRSA strains are now unreliable due to circulation of both ST 239 and ST 59 strains in the community and nosocomial settings. Initial antibiotic treatments should consider MRSA for patients with SSTIs in areas where MRSA is prevalent.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Changchien CH,Chen SW,Chen YY,Chu Cdoi
10.1186/s12879-016-1630-zsubject
Has Abstractpub_date
2016-06-10 00:00:00pages
276issn
1471-2334pii
10.1186/s12879-016-1630-zjournal_volume
16pub_type
杂志文章abstract:BACKGROUND:Drug resistant tuberculosis is a major public health problem in Morocco and worldwide. Treatment outcome of drug resistant tuberculosis is poor and requires a long period of treatment with many toxic and expensive antituberculosis drugs. The aim of this study is to evaluate treatment outcomes of drug resista...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3931-5
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:In some populations, complete shifts in the genotype of the strain of measles circulating in the population have been observed, with given genotypes being replaced by new genotypes. Studies have postulated that such shifts may be attributable to differences between the fitness of the new and the old genotype...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-44
更新日期:2008-04-11 00:00:00
abstract:BACKGROUND:Melioidosis has become an emerging infection in Sri Lanka; a country which is considered non endemic for it. Paraplegia due to Burkholderia pseudomallei is a very rare entity encountered even in countries where the disease is endemic. There are no reported cases of transverse myelitis due to melioidosis in S...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-232
更新日期:2012-09-28 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05610-6
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis is an inflammatory disorder in which the role of bacteria remains uncertain. While sinus outflow obstruction is often an initiating event, mucosal inflammation and dysbiosis may persist or develop in sinuses with widely patent surgical openings. Understanding of the relationship betwee...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3272-9
更新日期:2018-08-30 00:00:00
abstract:BACKGROUND:Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub-Saharan Africa. The Efé pygmies living in Democratic Republic of the Congo are known to be ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1607-y
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:The emerging resistance to the extended-spectrum cephalosporins (ESCs) in Neisseria gonorrhoeae together with increasing incidence of gonorrhoea cases in many countries have been global public health concerns. However, in recent years the levels of ESC resistance have decreased in several regions worldwide. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1013-x
更新日期:2015-08-11 00:00:00
abstract:BACKGROUND:The role of the surface capsular polysaccharides (CPs) of Mycobacterium tuberculosis (Mtb) in the pathogenesis of infection and disease, as well their potential for use as diagnostic reagents and vaccine antigens, are unknown. METHODS:Serum antibody to two CPs of Mtb, arabinomannan (AM) and glucan (Glu), we...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-276
更新日期:2013-06-19 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-78
更新日期:2014-02-12 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-46
更新日期:2005-06-14 00:00:00
abstract:BACKGROUND:Data for predicting which patients with pandemic influenza A (H1N1) infection are likely to run a complicated course are sparse. We retrospectively studied whether the admission serum C-reactive protein (CRP) levels can serve as a predictor of illness severity. METHODS:Included were all consecutive adult pa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-288
更新日期:2010-10-04 00:00:00
abstract:BACKGROUND:Despite a resurgence in control efforts, malaria remains a serious public-health problem, causing millions of deaths each year. One factor that complicates malaria-control efforts is clinical immunity, the acquired immune response that protects individuals from symptoms despite the presence of parasites. Cli...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-428
更新日期:2013-09-11 00:00:00
abstract:BACKGROUND:Recent analysis of trends of non-invasive infections with methicillin resistant Staphylococcus aureus (MRSA), of trends of MRSA infections in outpatient settings and of co-resistance profiles of MRSA isolates are scarce or lacking in Germany. METHODS:We analysed data from the Antimicrobial Resistance Survei...
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pub_type: 杂志文章
doi:10.1186/s12879-017-2271-6
更新日期:2017-02-23 00:00:00
abstract:BACKGROUND:Delayed diagnosis and treatment of tuberculosis (TB) results in severe disease and a higher mortality. It also leads to an increased period of infectivity in the community. The objective of this study was to determine the length of delays, and analyze the factors affecting the delay from onset of symptoms of...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-112
更新日期:2005-12-12 00:00:00
abstract:BACKGROUND:The outbreak of the novel coronavirus (COVID-19) that was firstly reported in Wuhan, China, with cases now confirmed in more than 100 countries. However, COVID-19 pneumonia with spontaneous pneumothorax is unknown. CASE PRESENTATION:We reported a case of 66-year-old man infected with COVID-19, presenting wi...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05384-x
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso. METHODS:Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urb...
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pub_type: 杂志文章
doi:10.1186/1471-2334-13-164
更新日期:2013-04-04 00:00:00
abstract:BACKGROUND:Diarrhea is the second most common cause of death among children less than 5 years of age worldwide. The etiological agents of diarrhea in the southeast coastal area of China were studied from July 2009 to December 2014. METHODS:A total of the 2318 patients were enrolled in this study and examined for the p...
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pub_type: 杂志文章
doi:10.1186/s12879-016-1760-3
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:The rate of vertical HIV transmission has decreased in Brazil, but regional inequalities suggest problems in implementing control measures during pregnancy and delivery. The aims of this study were to ascertain the coverage of HIV testing during prenatal care and estimate the prevalence of HIV infection duri...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0837-8
更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Globally, diarrhea is the leading cause of morbidity and mortality among less than 5 years old children and it contributes to the deaths of approximately one million children every year. In Ethiopia, diarrhea is the second cause of under-five mortality and morbidity. However, in the study area, studies were ...
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pub_type: 杂志文章
doi:10.1186/s12879-019-4445-x
更新日期:2019-09-13 00:00:00
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doi:10.1186/s12879-020-05640-0
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doi:10.1186/s12879-018-3423-z
更新日期:2018-10-16 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3134-5
更新日期:2018-06-05 00:00:00
abstract:BACKGROUND:A birth cohort dedicated to studying infections in early childhood may be assisted by parental recording of symptoms on a daily basis and a collection of biomaterials. We aimed at testing the feasibility of this approach for use in a long-term study focusing on infections in children in Germany. METHODS:Par...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1189-0
更新日期:2015-10-22 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3741-9
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND:The differential expression of virulence genes is often used by microbial pathogens in adapting to the environment of their host. The differential expression of such sets of genes can be regulated by RNA polymerase sigma factors. Some sigma factors are differentially expressed, which can provide a means to i...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-3-15
更新日期:2003-07-11 00:00:00
abstract:BACKGROUND:Complete clearance of intracellular viruses depends on effector cells of innate and adaptive immune systems. This study aimed to identify the relationships among antiviral cytokines produced by natural killer (NK) and T cells and clinical-virological characteristics in untreated chronic hepatitis B (CHB) pat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05233-x
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Non-adherence to tuberculosis (TB) treatment is the most important cause of poor TB outcomes, and improving support for TB patients is a primary priority for governments, but there has been little research on the effects of family, social and national policy support factors on TB treatment adherence. The cur...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05354-3
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-2-22
更新日期:2002-10-04 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) has significantly decreased HIV/AIDS-related morbidity and mortality. However, globally, many people living with HIV die from non-AIDS related illnesses including liver diseases which occur partly due to co-infection with HBV and or HCV. The aim of this study was to determine the...
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pub_type: 杂志文章
doi:10.1186/s12879-019-4027-y
更新日期:2019-05-03 00:00:00