Abstract:
BACKGROUND:Eight genotypes of Hepatitis B virus designated A-H, have been known but in Pakistan, no such data is available on the prevalent HBV genotypes. Therefore, the subject study was conducted to determine HBV genotypes in the indigenous Pakistani population. METHODS:A total of 690 individuals were enrolled for HBV screening with EIA and nested PCR. Positive samples were further analyzed to determine HBV genotypes (A-F) by multiplex-PCR using type specific primers. RESULTS:110 (15.94%) individuals were positive for HBV, including 64% males and 36% females. Out of these, 66 samples (65.34%) were classified into genotype D, 27 (26.73%) were of genotype B while 5(4.95%) had genotype A. In 3 (2.98%) samples, multiple genotypes were detected (genotype A+B; 2(1.99%) and genotypes B+D; 1(0.99%). Nine (8.18%) samples remained untyable. CONCLUSION:In Asia, genotypes B and C are the most prevalent but our study reveals that genotype D is predominant and HBV infection constitutes a significant health problem in Pakistan.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Alam MM,Zaidi SZ,Malik SA,Shaukat S,Naeem A,Sharif S,Angez M,Butt JAdoi
10.1186/1471-2334-7-115subject
Has Abstractpub_date
2007-10-08 00:00:00pages
115issn
1471-2334pii
1471-2334-7-115journal_volume
7pub_type
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-04-11 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2018-04-13 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2011-06-16 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章
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更新日期:2016-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-22 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2012-06-12 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-10-07 00:00:00
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pub_type: 杂志文章,meta分析,评审
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