Abstract:
BACKGROUND:Immunization policymakers at global and local levels need to establish priorities among new vaccines competing for limited resources. However, comparison of the potential impact of single vaccination programs is challenging, primarily due to the limited number of vaccine analyses as well as their differing analytic approaches and reporting formats. The purpose of this study is to provide early insight into how the comparative impact of different new vaccines could be assessed in resource-poor settings with respect to affordability, cost-effectiveness, and distributional equity. METHODS:We compared the health, economic, and financial consequences of introducing the two vaccines in 72 GAVI-eligible countries using a number of different outcome measures to evaluate affordability, cost-effectiveness, and distributional equity. We use simple static models to standardize the analytic framework and improve comparability between the two new vaccines. These simple models were validated by leveraging previously developed, more complex models for rotavirus and human papillomavirus (HPV). RESULTS:With 70% coverage of a single-age cohort of infants and pre-adolescent girls, the lives saved with rotavirus (~274,000) and HPV vaccines (~286,000) are similar, although the timing of averted mortality differs; rotavirus-attributable deaths occur in close proximity to infection, while HPV-related cancer deaths occur largely after age 30. Deaths averted per 1000 vaccinated are 5.2 (rotavirus) and 12.6 (HPV). Disability-adjusted life years (DALYs) averted were ~7.15 million (rotavirus) and ~1.30 million (HPV), reflecting the greater influence of discounting on the latter, given the lagtime between vaccination and averted cancer. In most countries (68 for rotavirus and 66 for HPV, at the cost of I$25 per vaccinated individual) the incremental cost per DALY averted was lower than each country's GDP per capita. Financial resources required for vaccination with rotavirus are higher than with HPV since both genders are vaccinated. CONCLUSIONS:While lifesaving benefits of rotavirus and HPV vaccines will be realized at different times, the number of lives saved over each target populations' lifetimes will be similar. Model-based analyses that use a standardized analytic approach and generate comparable outputs can enrich the priority-setting dialogue. Although new vaccines may be deemed cost-effective, other factors including affordability and distributional equity need to be considered in different settings. We caution that for priority setting in an individual country, more rigorous comparisons should be performed, using more comprehensive models and considering all relevant vaccines and delivery strategies.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Kim SY,Sweet S,Chang J,Goldie SJdoi
10.1186/1471-2334-11-174subject
Has Abstractpub_date
2011-06-16 00:00:00pages
174issn
1471-2334pii
1471-2334-11-174journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Gambia is the second GAVI support-eligible country to introduce the 7-valent pneumococcal conjugate vaccine (PCV7), but a country-specific cost-effectiveness analysis of the vaccine is not available. Our objective was to assess the potential impact of PCVs of different valences in The Gambia. METHODS:We syn...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-260
更新日期:2010-09-03 00:00:00
abstract:BACKGROUND:To explore the kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19. METHODS:This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 designated hospitals of Zhoushan, Zhejia...
journal_title:BMC infectious diseases
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更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Microascus cirrosus, the teleomorph of Scopulariopsis spp., is a saprobic species with a worldwide distribution and rarely causes human infection. In the present paper, we present the first case of primary cutaneous M. cirrosus infection in a Chinese female. CASE PRESENTATION:A 17-year-old female presented ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3535-5
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2387-8
更新日期:2017-04-21 00:00:00
abstract:BACKGROUND:The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). METHODS:Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admis...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
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更新日期:2015-08-21 00:00:00
abstract:BACKGROUND:Device-associated health care-associated infections (DA-HAIs) in intensive care unit (ICU) patients constitute a major therapeutic issue complicating the regular hospitalisation process and having influence on patients' condition, length of hospitalisation, mortality and therapy cost. METHODS:The study invo...
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doi:10.1186/s12879-020-05482-w
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:Varicella is a common childhood disease. Only 5% of first varicella-zoster-virus infections occur asymptomatically. Most data on the burden of varicella stem from health service databases. This study aims to provide insight in the burden of varicella from a parent's perspective including cases outside the he...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-320
更新日期:2011-11-17 00:00:00
abstract:BACKGROUND:Herpes simplex virus type-2 (HSV-2) is one of the most common sexually transmitted infections that facilitate human immunodeficiency virus (HIV) acquisition by over two fold or more. The development of HSV-2 control methods as a measure to control HIV epidemic in high HSV-2/HIV areas has become a priority. T...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-325
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:We describe a case of severe Guillain-Barre syndrome (GBS) associated with chronic active hepatitis C and mixed cryoglobulinemia (MC). To our knowledge, this association between GBS and hepatitis C virus (HCV) infection has been rarely reported. CASE PRESENTATION:A 56-year-old man developed symmetrical musc...
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doi:10.1186/s12879-019-4278-7
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:In order to investigate the epidemiology, molecular characteristics, and distribution of extended-spectrum β-lactamase (ESBL)- and AmpC-producing Escherichia coli from community-onset infections in Chinese county hospitals. METHODS:E. coli isolates were collected from patients with community-onset infection...
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doi:10.1186/s12879-014-0659-0
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children. METHODS:A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plas...
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-09-21 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) continues to be a public health challenge in Saudi Arabia, particularly for the elderly. This study was conducted to estimate mortality per 1000 person-year among TB and resistant TB cases and to identifying factors associated with mortality. METHODS:This is a retrospective cohort study of...
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doi:10.1186/s12879-019-4063-7
更新日期:2019-05-16 00:00:00
abstract:BACKGROUND:Retaining patients on antiretroviral treatment in care is critical to sustaining the 90:90:90 vision. Nigeria has made some progress in placing HIV-positive patients on treatment. In an effort to increase access to treatment, ART decentralization has been implemented in the country. This is aimed at strength...
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更新日期:2019-07-22 00:00:00
abstract:BACKGROUND:The potential impact of an influenza pandemic can be assessed by calculating a set of transmissibility parameters, the most important being the reproduction number (R), which is defined as the average number of secondary cases generated per typical infectious case. METHODS:We conducted a systematic review t...
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pub_type: 杂志文章,评审
doi:10.1186/1471-2334-14-480
更新日期:2014-09-04 00:00:00
abstract:BACKGROUND:PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of cerebro-spinal fluid (CSF). The assay's potential for accurate, fast and inexpensive discrimination of bacteria-free CSF makes it an ideal adjunct for confident exclusio...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05160-x
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Under-reporting of tuberculosis (TB) cases complicates disease control, hinders contact tracing and alters the accuracy of epidemiological data, including disease burden. The objective of the present study is to evaluate the proportion of unreported TB cases in Spanish healthcare facilities and to identify t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1047-0
更新日期:2015-07-29 00:00:00
abstract:BACKGROUND:Bloodstream infections due to Candida species cause significant morbidity and mortality, and the epidemiology of Candida infection is changing. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance. METHODS:The medical and electronic records of all patie...
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pub_type: 杂志文章
doi:10.1186/1471-2334-13-337
更新日期:2013-07-22 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB is being threatened by the increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series of seven MDR-TB cases in migrant patients with identical Mycobacterium tuberculosis strains we aim to illu...
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pub_type: 杂志文章
doi:10.1186/s12879-020-05381-0
更新日期:2020-09-17 00:00:00
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pub_type: 杂志文章
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更新日期:2008-05-17 00:00:00
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更新日期:2016-11-21 00:00:00
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更新日期:2019-09-04 00:00:00
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更新日期:2018-11-03 00:00:00
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更新日期:2013-02-02 00:00:00
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更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes of patients with hematologic malignancy and IA who were treated with voriconazole using the diagnost...
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更新日期:2018-12-13 00:00:00
abstract:BACKGROUND:Non-brucellar and non-tuberculous infectious sacroiliitis (ISI) is a rare disease, with misleading clinical signs that delay diagnosis. Most observations are based on isolated case reports or small case series. Our aim was to describe the clinical, bacteriological, and radiological characteristics of ISI, as...
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pub_type: 杂志文章,多中心研究
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更新日期:2012-11-15 00:00:00
abstract:BACKGROUND:Mycolicibacterium fortuitum is a species of the rapidly growing mycobacteria that can cause pulmonary infection. It is susceptible to multiple antibiotics both in vitro and in clinical practice, so that any combination of susceptible drugs is effective. However, we encountered a case of infection due to fluo...
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pub_type: 杂志文章
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更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Yeasts, mostly Candida, are important causes of bloodstream infections (BSI), responsible for significant mortality and morbidity among hospitalized patients. The epidemiology and species distribution vary from different regions. The goals of this study were to report the current epidemiology of Candida BSI ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-241
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Refugees in sub-Saharan Africa face both the risk of HIV infection and barriers to HIV testing. We conducted a pilot study to determine the feasibility and acceptability of home-based HIV testing in Nakivale Refugee Settlement in Uganda and to compare home-based and clinic-based testing participants in Nakiv...
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pub_type: 杂志文章
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更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Inappropriate antibiotic use is linked to the spread of antimicrobial resistance worldwide, but there are limited systemic data on antibiotic utilization in low- and middle-income countries. The purpose of this study was to evaluate the prevalence and patterns of antibiotic prescription in an ambulatory care...
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pub_type: 杂志文章
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更新日期:2021-01-21 00:00:00