Abstract:
BACKGROUND:The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). METHODS:Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admission and weekly screenings were performed by using selective media for methicillin resistant Staphylococcus aureus, extended-spectrum beta-lactamase-producing Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa. For the two latters, resistance to ceftazidime defined MDRO. Backward logistic regression models were designed to assess factors independently associated with MDRO carriage on admission and MDRO acquisition within ICUs. RESULTS:686 patients were included, and the MDRO prevalence rate on admission was 30.5 % (32.7 % for ESBL-positive Enterobacteriaceae, 3.2 % for MRSA). Antibiotic treatment prior to ICU admission was independently associated with carriage on admission (OR: 1.4) in multivariate analysis. A total of 104 patients acquired ≥1 MDRO in ICU (overall attack rate: 23.7 %; 14.9 % for ESBL-positive Enterobacteriaceae, and 5.1 % for MRSA). The MDRO attack rate increased from 13.2 % in the first week to 82.1 % for ICU stay > 3 weeks. Duration of antibiotic exposure (OR: 1.16; 1.1-1.2) and prior antibiotic treatment before ICU (OR: 2.1; 1.1-3.3) were associated with MDRO acquisition in multivariate analysis. The MDRO prevalence rate on ICU discharge was 51.2 % and the global prevalence density rate 71 per 1000 hospital-days. CONCLUSION:More than one out of two patients was MDRO carrier on ICU discharge in Chinese hospitals. This is the result of the combination of a high MDRO prevalence rate on ICU admission and a high MDRO acquisition rate within ICU.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Ma X,Wu Y,Li L,Xu Q,Hu B,Ni Y,Wu A,Sun S,Jarlier V,Robert Jdoi
10.1186/s12879-015-1105-7subject
Has Abstractpub_date
2015-08-21 00:00:00pages
358issn
1471-2334pii
10.1186/s12879-015-1105-7journal_volume
15pub_type
杂志文章,多中心研究abstract:BACKGROUND:Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has broad-spectrum in vitro activity against bacteria commonly encountered in complicated intra-abdominal infections (cIAIs), including aerobic and facultative Gram-positive and Gram-negative bacteria and anaerobic bacteria. In the curren...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2334-10-217
更新日期:2010-07-21 00:00:00
abstract:BACKGROUND:Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical are...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1704-y
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:The outbreak of the novel coronavirus (COVID-19) that was firstly reported in Wuhan, China, with cases now confirmed in more than 100 countries. However, COVID-19 pneumonia with spontaneous pneumothorax is unknown. CASE PRESENTATION:We reported a case of 66-year-old man infected with COVID-19, presenting wi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05384-x
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abstract:BACKGROUND:The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda. METHODS:HIV-negative, high-risk women were seen q...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
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更新日期:2015-07-30 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-3-27
更新日期:2003-11-14 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-015-0782-6
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:Annual influenza vaccination of healthcare workers (HCWs) is recommended in Australia, but uptake in healthcare facilities has historically been low (approximately 50%). The objective of this study was to develop and implement a dedicated campaign to improve uptake of staff influenza annual vaccination at a ...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-015-0765-7
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journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
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更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:Over the last decade, increases in the number of outbreaks of hand, foot and mouth disease (HFMD) have shifted the disease into the public health spotlight in China. Children under the age of five years are particularly susceptible, with fatalities recorded. However, estimating the burden of HFMD has been di...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-437
更新日期:2014-08-12 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0590-4
更新日期:2014-11-14 00:00:00
abstract:BACKGROUND:Due to the populations' susceptibility, DENV-4 introduction in 2010 led to the occurrence of explosive epidemics in the following years in Brazil. In 2011, DENV-4 was identified in Rio de Janeiro (RJ) and it was prevalent in 2012 and 2013. Here, we aimed to characterize clinical, epidemiological and laborato...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2488-4
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abstract:BACKGROUND:Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine. METHODS:To investigate the contribution of the miRNA-29 family to HIV-1 infection in vivo, we compared miRNA-29 expression in PBM...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0768-4
更新日期:2015-02-12 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-126
更新日期:2010-05-21 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-1-10
更新日期:2001-01-01 00:00:00
abstract::Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can be achieved at the point-of-care within just 30 minutes using the Determine TB-LAM, which is a commercially ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-407
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...
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pub_type: 杂志文章
doi:10.1186/s12879-020-4775-8
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pub_type: 杂志文章
doi:10.1186/1471-2334-6-65
更新日期:2006-03-30 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2018-02-27 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1186/s12879-016-1825-3
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND:Antimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority. METHODS:We examined recent time trends in the utilization of narrow- and broad-spectrum antibio...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3964-9
更新日期:2019-04-24 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-017-2920-9
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Little is known about the prevalence of HIV or HCV in injecting drug users (IDUs) in Serbia and Montenegro. We measured prevalence of antibodies to HIV (anti-HIV) and hepatitis C virus (anti-HCV), and risk factors for anti-HCV, in community-recruited IDUs in Belgrade and Podgorica, and determined the perform...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-14
更新日期:2009-02-09 00:00:00
abstract:BACKGROUND:Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan. MET...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-262
更新日期:2012-10-18 00:00:00
abstract:BACKGROUND:Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mutations in the Quinolone Resistance Determining Region (QRDR) of gyrA and gyrB genes of Mycobacterium...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05112-5
更新日期:2020-06-01 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05254-6
更新日期:2020-07-23 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2020-01-28 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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