Unusual presentation of fatal disseminated varicella zoster virus infection in a patient with lupus nephritis: a case report.

Abstract:

BACKGROUND:The risk of life-threatening complications, such as visceral disseminated varicella zoster virus (VZV) infection, is greater in immunosuppressed individuals, such as systemic lupus erythematosus (SLE) patients. CASE PRESENTATION:Here, a case is reported of a Caucasian woman diagnosed with lupus nephritis and anti-phospholipid syndrome, who was subjected to mycophenolate mofetil and high-dose steroid remission-induction therapy. Two months later she developed abdominal pain followed by a fatal rapid multi-organ failure. As no typical skin rashes were evident, death was initially attributed to catastrophic anti-phospholipid syndrome. However, autopsy and virological examinations on archival material revealed a disseminated VZV infection. CONCLUSIONS:Overall, this case highlights the importance of having a high clinical suspicion of fatal VZV infections in heavily immunosuppressed SLE patients even when typical signs and symptoms are lacking.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Vassia V,Croce A,Ravanini P,Leutner M,Saglietti C,Fangazio S,Quaglia M,Smirne C

doi

10.1186/s12879-020-05254-6

subject

Has Abstract

pub_date

2020-07-23 00:00:00

pages

538

issue

1

issn

1471-2334

pii

10.1186/s12879-020-05254-6

journal_volume

20

pub_type

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