Abstract:
BACKGROUND:Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. METHODS:A five-year cross-sectional study was conducted in a tertiary children's hospital in Zhejiang. Consecutive stool specimens from outpatient children with acute gastroenteritis were cultured for C. difficile, and isolates then were analyzed for toxin genes, multi-locus sequence type and antimicrobial resistance. Diarrhea-related viruses were detected, and demographic data were collected. RESULTS:A total of 115 CDI cases (14.3%), and 69 co-infected cases with both viruses and toxigenic C. difficile, were found in the 804 stool samples. The 186 C. difficile isolates included 6 of toxin A-positive/toxin B-positive/binary toxin-positive (A+B+CDT+), 139 of A+B+CDT-, 3 of A-B+CDT+, 36 of A-B+CDT- and 2 of A-B-CDT-. Sequence types 26 (17.7%), 35 (11.3%), 39 (12.4%), 54 (16.7%), and 152 (11.3%) were major genotypes with significant differences among different antimicrobial resistances (Fisher's exact test, P < 0.001). The A-B+ isolates had significantly higher resistance, compared to erythromycin, rifampin, moxifloxacin, and gatifloxacin, than that of the A+B+ (χ2 = 7.78 to 29.26, P < 0.01). The positive CDI rate in infants (16.2%) was significantly higher than that of children over 1 year old (10.8%) (χ2 = 4.39, P = 0.036). CONCLUSIONS:CDI has been revealed as a major cause of acute gastroenteritis in children with various genotypes. The role of toxigenic C. difficile and risk factors of CDI should be emphatically considered in subsequent diarrhea surveillance in children from China.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Shuai H,Bian Q,Luo Y,Zhou X,Song X,Ye J,Huang Q,Peng Z,Wu J,Jiang J,Jin Ddoi
10.1186/s12879-020-05030-6subject
Has Abstractpub_date
2020-05-13 00:00:00pages
343issue
1issn
1471-2334pii
10.1186/s12879-020-05030-6journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Antimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority. METHODS:We examined recent time trends in the utilization of narrow- and broad-spectrum antibio...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3964-9
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
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journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-110
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1640-x
更新日期:2016-06-16 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2225-z
更新日期:2017-02-13 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/s12879-020-05092-6
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3986-3
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pub_type: 杂志文章
doi:10.1186/1471-2334-10-288
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pub_type: 杂志文章
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更新日期:2010-04-12 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:The public health response to Zika outbreak has mostly focused on epidemiological surveillance, vector control, and individual level preventative measures. This qualitative study employs a social-ecological framework to examine how macro (historical, legislative, political, socio-economic factors), meso (sou...
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pub_type: 杂志文章
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更新日期:2020-04-03 00:00:00
abstract:BACKGROUND:Estimation of pre-immunisation prevalence of HPV and distribution of HPV types is fundamental to understanding the subsequent impact of HPV vaccination. We describe the type specific prevalence of HPV in females aged 20-21 in Scotland who attended or defaulted from cervical screening using three specimen typ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2013-11-05 00:00:00
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pub_type: 杂志文章
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更新日期:2011-09-28 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2013-09-14 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-16 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2002-10-04 00:00:00