Blood borne transit of CJD from brain to gut at early stages of infection.


BACKGROUND:In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs. METHODS:We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and monitored the progressive appearance of abnormal PrP in peripheral tissues over time. RESULTS:Abnormal PrP was detected in lymphoreticular tissues of the gastrointestinal tract as early as 28 to 32 days after infection by both routes. This change persisted until the terminal stages of disease. In contrast, abnormal PrP was not detected in brain or spinal cord until 80 to 120 days after ic inoculation, or until 170 days after ip inoculation. CONCLUSIONS:Brain lacks significant lymphatic drainage, and has little infectivity before 40 days, even after ic inoculation. Thus the infectious inoculum must spread to the gut by a vascular route, a direction opposite to that generally assumed. This interpretation is consistent with previous studies demonstrating white blood cell infectivity as well as perivascular PrP accumulations in CJD. Notably, enteric infection at early as well as later stages of disease, and regardless of the route of agent entry, implicates potential environmental spread by fecal matter.


BMC Infect Dis


BMC infectious diseases


Radebold K,Chernyak M,Martin D,Manuelidis L





Has Abstract


2001-01-01 00:00:00








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    pub_type: 杂志文章


    authors: Tukasan C,Furlan NB,Estofolete CF,Nogueira ML,da Silva NS

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    abstract:BACKGROUND:Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbo...

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    authors: Gadia CLB,Manirakiza A,Tekpa G,Konamna X,Vickos U,Nakoune E

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  • Effectiveness of the polysaccharide pneumococcal vaccine among HIV-infected persons in Brazil: a case control study.

    abstract:BACKGROUND:Polysaccharide pneumococcal vaccine is recommended for use in HIV-infected adults in Brazil but there is uncertainty about its effectiveness in this patient population. The main objective of this study was to assess the effectiveness of the 23-valent polysaccharide pneumococcal vaccine against invasive pneum...

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    authors: Veras MA,Enanoria WT,Castilho EA,Reingold AL

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    pub_type: 杂志文章


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    authors: McLendon MM,Shinnick TM

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    authors: Lala S,Dheda K,Chang JS,Huggett JF,Kim LU,Johnson MA,Rook GA,Keshav S,Zumla A

    更新日期:2007-08-16 00:00:00

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    更新日期:2018-08-22 00:00:00

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    authors: Apelt N,Hartberger C,Campe H,Löscher T

    更新日期:2010-05-25 00:00:00

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    abstract:BACKGROUND:To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to e...

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    authors: Premaratna R,Blanton LS,Samaraweera DN,de Silva GN,Chandrasena NT,Walker DH,de Silva HJ

    更新日期:2017-01-13 00:00:00

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    authors: Morales-García C,Rodrigo T,García-Clemente MM,Muñoz A,Bermúdez P,Casas F,Somoza M,Milá C,Penas A,Hidalgo C,Casals M,Caylá JA,Working Group on Under-reporting of Tuberculosis in Spain.

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    authors: Huyen MN,Kremer K,Lan NT,Buu TN,Cobelens FG,Tiemersma EW,de Haas P,van Soolingen D

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,随机对照试验


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    更新日期:2012-11-06 00:00:00

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    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Bai L,Zhang Z,Zhang H,Li X,Yu Q,Lin H,Yang W

    更新日期:2008-06-06 00:00:00

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    pub_type: 杂志文章


    authors: Stakenborg T,Vicca J,Butaye P,Maes D,De Baere T,Verhelst R,Peeters J,de Kruif A,Haesebrouck F,Vaneechoutte M

    更新日期:2005-06-14 00:00:00