Procalcitonin for infections in the first week after pediatric liver transplantation.

Abstract:

BACKGROUND:Procalcitonin (PCT) has become a commonly used serum inflammatory marker. Our aim was to describe the kinetics and usefulness of serial post-operative PCT measurements to detect bacterial infection in a cohort of children immediately after pediatric liver transplantation (pLT). METHODS:We performed a retrospective chart review of a cohort of pLT recipients with serial serum PCT measurements in the first week following pLT. The presence of infection was determined on clinical and biological parameters. Normal PCT was defined as < 0.5 (ng/ml). RESULTS:Thirty-nine patients underwent 41 pLT. PCT was measured daily during the first week post pLT. Values first increased following surgery and then decreased, nearing 0.5 ng/ml at day seven. Peak PCT reached a median of 5.61 ng/ml (IQR 3.83-10.8). Seventeen patients were considered to have an infection. There was no significant difference in daily PCT or peak PCT between infected and non infected patients during the first post-operative week. AUC of ROC curve for PCT during first week was never higher than 0.6. CONCLUSIONS:We conclude that serial PCT measurements during the first week after pLT is not useful to identify patients with bacterial infections. Rather, we propose that serum PCT may be useful after the first week post pLT.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Cousin VL,Lambert K,Trabelsi S,Galetto-Lacour A,Posfay-Barbe KM,Wildhaber BE,McLin VA

doi

10.1186/s12879-017-2234-y

subject

Has Abstract

pub_date

2017-02-15 00:00:00

pages

149

issue

1

issn

1471-2334

pii

10.1186/s12879-017-2234-y

journal_volume

17

pub_type

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