Abstract:
BACKGROUND:Hepatitis E virus (HEV) may be resistant to immunosuppression reduction and ribavirin treatment in kidney transplant recipients because of mutant strains and severe side effects of ribavirin which conduct to dose reduction. Sofosbuvir efficacy is controversial. Peg-interferon 2 alpha (PEG-IFN) is currently contraindicated due to a high risk of acute humoral and cellular rejection. The present study assessed, for the first time, the effect of PEG-IFN in a kidney transplant recipient infected with HEV. CASE PRESENTATION:The patient had chronic active HEV that was resistant to immunosuppression reduction and optimal ribavirin treatment. He developed significant liver fibrosis. PEG-IFN was administered for 10 months, and it was well tolerated and did not induce rejection. A sustained virological response was obtained. CONCLUSIONS:We conclude that prolonged treatment with PEG-IFN in kidney transplant recipients infected with HEV could be considered as a salvage option.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Ollivier-Hourmand I,Lebedel L,Lecouf A,Allaire M,Nguyen TTN,Lier C,Dao Tdoi
10.1186/s12879-020-05212-2subject
Has Abstractpub_date
2020-07-16 00:00:00pages
522issue
1issn
1471-2334pii
10.1186/s12879-020-05212-2journal_volume
20pub_type
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pub_type: 已发布勘误
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