Pegylated interferon may be considered in chronic viral hepatitis E resistant to ribavirin in kidney transplant recipients.

Abstract:

BACKGROUND:Hepatitis E virus (HEV) may be resistant to immunosuppression reduction and ribavirin treatment in kidney transplant recipients because of mutant strains and severe side effects of ribavirin which conduct to dose reduction. Sofosbuvir efficacy is controversial. Peg-interferon 2 alpha (PEG-IFN) is currently contraindicated due to a high risk of acute humoral and cellular rejection. The present study assessed, for the first time, the effect of PEG-IFN in a kidney transplant recipient infected with HEV. CASE PRESENTATION:The patient had chronic active HEV that was resistant to immunosuppression reduction and optimal ribavirin treatment. He developed significant liver fibrosis. PEG-IFN was administered for 10 months, and it was well tolerated and did not induce rejection. A sustained virological response was obtained. CONCLUSIONS:We conclude that prolonged treatment with PEG-IFN in kidney transplant recipients infected with HEV could be considered as a salvage option.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Ollivier-Hourmand I,Lebedel L,Lecouf A,Allaire M,Nguyen TTN,Lier C,Dao T

doi

10.1186/s12879-020-05212-2

subject

Has Abstract

pub_date

2020-07-16 00:00:00

pages

522

issue

1

issn

1471-2334

pii

10.1186/s12879-020-05212-2

journal_volume

20

pub_type

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