Abstract:
BACKGROUND:To determine the prevalence of enteric infections in Aboriginal children aged 0-2 years using conventional and molecular diagnostic techniques and to explore associations between the presence of pathogens and child growth. METHODS:Cross-sectional analysis of Aboriginal children (n = 62) residing in a remote community in Northern Australia, conducted from July 24th - October 30th 2017. Stool samples were analysed for organisms by microscopy (directly in the field and following fixation and storage in sodium-acetate formalin), and by qualitative PCR for viruses, bacteria and parasites and serology for Strongyloides-specific IgG. Child growth (height and weight) was measured and z scores calculated according to WHO growth standards. RESULTS:Nearly 60% of children had evidence for at least one enteric pathogen in their stool (37/62). The highest burden of infection was with adenovirus/sapovirus (22.9%), followed by astrovirus (9.8%) and Cryptosporidium hominis/parvum (8.2%). Non-pathogenic organisms were detected in 22.5% of children. Ten percent of children had diarrhea at the time of stool collection. Infection with two or more pathogens was negatively associated with height for age z scores (- 1.34, 95% CI - 2.61 to - 0.07), as was carriage of the non-pathogen Blastocystis hominis (- 2.05, 95% CI - 3.55 to - 0.54). CONCLUSIONS:Infants and toddlers living in this remote Northern Australian Aboriginal community had a high burden of enteric pathogens and non-pathogens. The association between carriage of pathogens/non-pathogens with impaired child growth in the critical first 1000 days of life has implications for healthy child growth and development and warrants further investigation. These findings have relevance for many other First Nations Communities that face many of the same challenges with regard to poverty, infections, and malnutrition.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hanieh S,Mahanty S,Gurruwiwi G,Kearns T,Dhurrkay R,Gondarra V,Shield J,Ryan N,Azzato F,Ballard SA,Orlando N,Nicholson S,Gibney K,Brimblecombe J,Page W,Harrison LC,Biggs BA,Child Health and Nutrition Study team.doi
10.1186/s12879-020-05685-1subject
Has Abstractpub_date
2021-01-06 00:00:00pages
9issue
1issn
1471-2334pii
10.1186/s12879-020-05685-1journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Shiga toxin-producing Escherichia coli (STEC) O157:H7 and related non-O157 STEC strains are enteric pathogens of public health concern worldwide, causing life-threatening diseases. Cattle are considered the principal hosts and have been shown to be a source of infection for both foodborne and environmental o...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-450
更新日期:2013-09-30 00:00:00
abstract:BACKGROUND:Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected are unaware of their disease limiting prevention and early treatment options. The purpose of this co...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0854-7
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:High blood levels of soluble urokinase Plasminogen Activator Receptor (suPAR) are associated with poor outcomes in human immunodeficiency-1 (HIV-1) infected individuals. Research on the clinical value of suPAR in HIV-1 infection led to the development of the suPARnostic(R) assay for commercial use in 2006. T...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-134
更新日期:2007-11-16 00:00:00
abstract:BACKGROUND:Erythema induratum of Bazin (EIB) - nodular vasculitis associated with Mycobacterium tuberculosis (TB) - and Tuberculosis-Associated Ocular Inflammation (TB-AOI) represent uncommon manifestations of TB. There is limited data and a lack of diagnostic and treatment standards for these conditions. METHODS:Elev...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3737-5
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Even though remarkable progress for diagnostics of pulmonary TB has been made, it is still a challenge to establish a definitive diagnosis for extrapulmonary TB (EPTB) in clinical practice. Among all the presentations of EPTB, cold abscesses are unusual and deceptive, which are often reported in the chest wa...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-020-05137-w
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target post-tuberculosis screening and care. METHODS:We enrolled 500 patients with smear-positive pulmonar...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05515-4
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the increase of LD in Belgium, we focused on hospital admissions of patients diagnosed with LD between 2000 ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2841-7
更新日期:2017-12-05 00:00:00
abstract::While true antimicrobial resistance to Chlamydia trachomatis is a rare occurrence, repeat chlamydia infections continue to be reported following treatment with a single 1 g dose of azithromycin or week long doxycycline - with considerable more concern about azithromycin treatment failure. While most repeat positive ca...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
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更新日期:2015-07-29 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3905-7
更新日期:2019-03-18 00:00:00
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journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/s12879-016-1896-1
更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens. The aim of this study was to investigate the prevalence and molecular characterization of PZA resistance among MDR-TB isolates collected in Chongqing municipality. M...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2761-6
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:There is little information on nasopharyngeal (NP) flora or bacteremia in HIV-infected children. Our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective study comparing daily and three times weekly trimethoprim-sulfamethoxazole (TMP-SMX) and isoniazid...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-40
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Group A Streptococcal (GAS) infections cause the autoimmune disease acute rheumatic fever (ARF), which can progress to chronic rheumatic heart disease (RHD). Treating pharyngitis caused by GAS with antibiotics is important in preventing ARF. However, it is difficult to distinguish these infections from GAS c...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4126-9
更新日期:2019-07-17 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-37
更新日期:2014-01-21 00:00:00
abstract:BACKGROUND:Toxoplasmosis is a worldwide zoonosis caused by the intracellular parasite Toxoplasma gondii. However, no effective vaccine is yet available. Poly(lactide-co-glycolide) polymers can reduce protein degradation and sustain the release of antigens over a long period, which could generate a long-lasting immune r...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1496-0
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterial pathogen which can invade different mammalian cells and reach to the central nervous system (CNS), leading to meningoencephalitis and brain abscesses. In the diagnosis of L. monocytogenes meningoencephalitis (LMM), the traditi...
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更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3127-4
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLR) 7 and 8 are important in single-stranded viral RNA recognition and may play a role in HIV infection and disease progression. We analyzed TLR7/8 expression and signaling in monocytes from HIV-infected and uninfected subjects to investigate a pathway with new potential for the suppres...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-5
更新日期:2012-01-14 00:00:00
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更新日期:2013-02-04 00:00:00
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abstract:BACKGROUND:Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB is being threatened by the increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series of seven MDR-TB cases in migrant patients with identical Mycobacterium tuberculosis strains we aim to illu...
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更新日期:2020-09-17 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-04 00:00:00
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更新日期:2017-01-13 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-05 00:00:00
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更新日期:2013-06-04 00:00:00
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更新日期:2017-07-26 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Specific land cover types and activities have been correlated with Trypanosoma brucei rhodesiense distributions, indicating the importance of landscape for epidemiological risk. However, methods proposed to identify specific areas with elevated epidemiological risk (i.e. where transmission is more likely to ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Diarrhea is the second most common cause of death among children less than 5 years of age worldwide. The etiological agents of diarrhea in the southeast coastal area of China were studied from July 2009 to December 2014. METHODS:A total of the 2318 patients were enrolled in this study and examined for the p...
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pub_type: 杂志文章
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更新日期:2016-08-20 00:00:00