Abstract:
BACKGROUND:Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance. The aim of this study was to identify the other pathogens that can cause febrile jaundice, for better management of patients. METHODS:Between 2008 and 2010, 198 sera negative for yellow fever IgM were randomly selected from 2177 samples collected during yellow fever surveillance. Laboratory analyses targeted four groups of pathogens: hepatitis B, C, delta and E viruses; dengue, chikungunya, Zika, Crimean-Congo haemorrhagic fever, West Nile and Rift Valley arboviruses; malaria parasites; and bacteria (leptospirosis). RESULTS:Overall, 30.9% sera were positive for hepatitis B, 20.2% for hepatitis E, 12.3% for hepatitis C and 8.2% for malaria. The majority of positive sera (40.4%) were from people aged 16-30 years. Co-infection with at least two of these pathogens was also found. CONCLUSION:These findings suggest that a systematic investigation should be undertaken of infectious agents that cause febrile jaundice in the CAR.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Gadia CLB,Manirakiza A,Tekpa G,Konamna X,Vickos U,Nakoune Edoi
10.1186/s12879-017-2840-8subject
Has Abstractpub_date
2017-11-29 00:00:00pages
735issue
1issn
1471-2334pii
10.1186/s12879-017-2840-8journal_volume
17pub_type
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