Abstract:
BACKGROUND:This study aims to investigate the clinical features of invasive community-acquired Staphylococcus aureus (CA-SA) infection in Chinese children and analyze its molecular features. METHODS:Clinical data and invasive CA-SA isolates were prospectively collected. Pediatric risk of mortality (PRISM) score was used for disease severity measurement. Molecular typing was then performed, followed by expression analysis for virulence genes. RESULTS:Among 163 invasive CA-SA infection cases, 71 (43.6%) were methicillin-resistant SA (MRSA) infections and 92 (56.4%) were methicillin-susceptible SA (MSSA). A total of 105 (64.4%) children were younger than 1 year old, and 79.7% (129/163) were under 3 years age. Thirteen kinds of diseases were observed, in which bacteremia and pneumonia accounted for 65.6% (107/163) and 52.8% (86/163), respectively. A total of 112 (68.1%) patients had two or more infective sites simultaneously, and four cases (2.5%) died. CA-MSSA more frequently caused multi-sites infections, bacteremia, and musculoskeletal infection than MRSA. A total of 25 sequence types (STs) were detected. MRSA mainly comprised ST59 (49/71, 69%), whereas the most frequent clonotypes were ST88 (15/92, 16.3%), ST25 (13/92, 14.1%), ST7 (13/92, 14.1%), ST2155 (12/92, 13%), and ST188 (9/92, 9.8%) for MSSA. Seven STs were common to both MSSA and MRSA groups. No differences in clinical presentation or PRISM score were found between the two groups or among different ST. The expression levels of the four known virulence genes varied among the six main ST clones. CONCLUSIONS:Invasive CA-SA infections were characterized by high incidence and multi-site infections in young children in China. The clinical manifestations of CA-MSSA were more frequently associated with multi-site infections, bacteremia and musculoskeletal infection than those of CA-MRSA. Isolated genotypes may be relevant to the expressions of virulence genes, but not to clinical manifestations.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Qiao Y,Ning X,Chen Q,Zhao R,Song W,Zheng Y,Dong F,Li S,Li J,Wang L,Zeng T,Dong Y,Yao K,Yu S,Yang Y,Shen Xdoi
10.1186/s12879-014-0582-4subject
Has Abstractpub_date
2014-11-07 00:00:00pages
582issn
1471-2334pii
s12879-014-0582-4journal_volume
14pub_type
杂志文章abstract:BACKGROUND:A reliable prediction of the causative agent of community-acquired pneumonia (CAP) is not possible based on clinical features. Our aim was to test, whether the measurement of the expression of complement receptors or Fcgamma receptors on neutrophils and monocytes would be a useful preliminary test to differe...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-11
更新日期:2006-01-24 00:00:00
abstract:BACKGROUND:The study of the endotoxin tolerance phenomenon in light of the recently defined roles of mast cells and toll-like receptors as essential components of the innate immune response and as orchestrators of acquired immunity may reveal potentially useful mechanisms of immunomodulation of infectious and allergic ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-240
更新日期:2010-08-14 00:00:00
abstract:BACKGROUND:Influenza vaccination is recognized as a primary public health intervention which prevents the illness of patients and relieves the societal burdens of influenza for medical community as well as the economy. To date, no effectiveness study of influenza vaccination has been conducted including a large populat...
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pub_type: 杂志文章
doi:10.1186/s12879-019-4186-x
更新日期:2019-07-05 00:00:00
abstract:BACKGROUND:Our aim was to determine the efficacy of a trivalent inactivated split virus influenza vaccine (TIV) against culture-confirmed influenza A and/or B in adults 18 to 64 years of age during the 2005/2006 season in the Czech Republic. METHODS:6203 subjects were randomized to receive TIV (N = 4137) or placebo (N...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-9-2
更新日期:2009-01-17 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sample size. Hence this study aimed to estimate HBV seroprevalence using a large inpatient population ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4091-3
更新日期:2019-05-20 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1186/s12879-019-4217-7
更新日期:2019-07-19 00:00:00
abstract:BACKGROUND:Influenza viruses are a major cause of morbidity and mortality worldwide. Vaccination remains a powerful tool for preventing or mitigating influenza outbreaks. Yet, vaccine supplies and daily administration capacities are limited, even in developed countries. Understanding how such constraints can alter the ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-207
更新日期:2011-08-01 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-136
更新日期:2014-03-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2334-13-432
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pub_type: 杂志文章
doi:10.1186/1471-2334-11-91
更新日期:2011-04-13 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-11 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12879-017-2819-5
更新日期:2017-11-28 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2334-13-25
更新日期:2013-01-22 00:00:00
abstract:BACKGROUND:Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, ga...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
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更新日期:2018-07-11 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2334-6-115
更新日期:2006-07-17 00:00:00
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更新日期:2014-07-13 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-10 00:00:00
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pub_type: 已发布勘误
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更新日期:2019-05-27 00:00:00
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更新日期:2020-08-20 00:00:00
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pub_type: 杂志文章
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更新日期:2011-04-14 00:00:00
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更新日期:2020-09-17 00:00:00
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pub_type: 杂志文章
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更新日期:2008-02-07 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-25 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-10-15 00:00:00