Immunological and virological characterization of HIV-1 viremia controllers in the North Region of Brazil.

Abstract:

BACKGROUND:A rare phenotype of clinical non-progressors to AIDS is not well understood and the new protocol for universal treatment, may block the understanding of viral control thus it is crucial to define this controversial group. METHODS:A cohort of 30 persons followed a criteria for viremia control groups 1 (VC1; n = 2) and 2 (VC2; n = 7) and non-viral controllers (NC; n = 21) including number of years of diagnosis, LTCD4+, LTCD8+ counts, plasma viral load and the absence of ART; 241 uninfected control persons were matched to age and sex. Infected persons were regularly examined and submitted to two or three annual laboratory measurements. Polymorphisms and allele frequencies of CCR5Δ32 and SDF1-3'A were detected in the genomic DNA. Plasma levels of cytokines (IL-2, IL-4, IL-5, IL-9, IL-10, IL-13, IL-17 and IFN-y) were measured. RESULTS:The group investigated is originated from a miscigenetic population and demographic and social characteristics were not significantly relevant. LTCD4+ median values were higher among VC than NC, but significantly lower than uninfected controls. Evolution of LTCD4+ and LTCD8+ counts, showed a slight increase of LTCD4+ among VC, but a significant decrease in the NC. The percentage of annual change in LTCD4+ was also significantly different between the groups. LTCD4+/LTCD8+ ratio was inverted but not significant among the VC, thus the ratio may be a useful biomarker for the VC. A clear signature indicated a change from Th1 to Th2 cytokine profiles from VC to NC, respectively. CONCLUSIONS:The knowledge of viral controllers characteristics in different population groups is important to define a strict universal definition for the sake of learning about the pathogenesis of HIV-1. Data on LTCD4+ seems to be stable and repetitive from published data, but the LTCD8+ response and the significance of LTCD4+/LTCD8+ ratio values are in need to further exploration as biomarkers. The change from Th1 to Th2 cytokine profile may help to design and adjust specific treatment protocols for the group.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Gomes STM,Gomes ÉR,Dos Santos MB,Lima SS,Queiroz MAF,Machado LFA,Cayres-Vallinoto IMV,Vallinoto ACR,de O Guimarães Ishak M,Ishak R

doi

10.1186/s12879-017-2491-9

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

381

issue

1

issn

1471-2334

pii

10.1186/s12879-017-2491-9

journal_volume

17

pub_type

杂志文章
  • Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women.

    abstract:BACKGROUND:Persistent high-risk (HR) human papillomavirus (HPV) infection and increased HR-HPV viral load are associated with the development of cancer. This study investigated the effect of human immunodeficiency virus (HIV) co-infection, HIV viral load and CD4 count on the HR-HPV viral load; and also investigated the...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-51

    authors: Mbulawa ZZ,Johnson LF,Marais DJ,Gustavsson I,Moodley JR,Coetzee D,Gyllensten U,Williamson AL

    更新日期:2014-01-31 00:00:00

  • An assessment of the usefulness of a rapid immuno-chromatographic test, "Determine trade mark malaria pf" in evaluation of intervention measures in forest villages of central India.

    abstract:BACKGROUND:Plasmodium falciparum malaria, is a major health problem in forested tribal belt of central India. Rapid and accurate methods are needed for the diagnosis of P. falciparum. We performed a blinded evaluation of the recently introduced Determine trade mark malaria pf test (Abbott, Laboratories, Japan) compared...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-1-10

    authors: Singh N,Shukla M

    更新日期:2001-01-01 00:00:00

  • The diagnostic utility of the "Thwaites' system" and "lancet consensus scoring system" in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients.

    abstract:BACKGROUND:Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The "Thwaites' system" and "Lancet consensus scoring system" are utilized to differentiate TBM from bacterial meningitis but their utility in subacute and chronic meningitis where TBM is an important consideration is...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-020-05502-9

    authors: Sulaiman T,Medi S,Erdem H,Senbayrak S,Ozturk-Engin D,Inan A,Civljak R,Nechifor M,Akbulut A,Crisan A,Ozguler M,Namiduru M,Savic B,Dulovic O,Pehlivanoglu F,Sengoz G,Yasar K,Inal AS,Parlak E,Johansen IS,Kursun E,Pa

    更新日期:2020-10-23 00:00:00

  • Fasting plasma glucose is an independent predictor for severity of H1N1 pneumonia.

    abstract:BACKGROUND:The pandemic influenza A (H1N1) virus emerged during 2009 and has spread worldwide. This virus can cause injuries to the lungs, liver, and heart. However, data regarding whether this influenza virus can affect pancreatic islets are limited. We investigated the effects of influenza A (H1N1) pneumonia on fasti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-104

    authors: Wang W,Chen H,Li Q,Qiu B,Wang J,Sun X,Xiang Y,Zhang J

    更新日期:2011-04-21 00:00:00

  • Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned.

    abstract:BACKGROUND:Ebola haemorrhagic fever (EHF) is infamous for its high case-fatality proportion (CFP) and the ease with which it spreads among contacts of the diseased. We describe the course of the EHF outbreak in Masindi, Uganda, in the year 2000, and report on response activities. METHODS:We analysed surveillance recor...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-11-357

    authors: Borchert M,Mutyaba I,Van Kerkhove MD,Lutwama J,Luwaga H,Bisoborwa G,Turyagaruka J,Pirard P,Ndayimirije N,Roddy P,Van Der Stuyft P

    更新日期:2011-12-28 00:00:00

  • Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report.

    abstract:BACKGROUND:Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-330

    authors: Schoffelen T,den Broeder AA,Nabuurs-Franssen M,van Deuren M,Sprong T

    更新日期:2014-06-15 00:00:00

  • Decreases in self-reported alcohol consumption following HIV counseling and testing at Mulago Hospital, Kampala, Uganda.

    abstract:BACKGROUND:Alcohol use has a detrimental impact on the HIV epidemic, especially in sub-Saharan Africa. HIV counseling and testing (HCT) may provide a contact opportunity to intervene with hazardous alcohol use; however, little is known about how alcohol consumption changes following HCT. METHODS:We utilized data from ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-403

    authors: Hahn JA,Fatch R,Wanyenze RK,Baveewo S,Kamya MR,Bangsberg DR,Coates TJ

    更新日期:2014-07-20 00:00:00

  • Burden of bacterial resistance among neonatal infections in low income countries: how convincing is the epidemiological evidence?

    abstract:BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-015-0843-x

    authors: Huynh BT,Padget M,Garin B,Herindrainy P,Kermorvant-Duchemin E,Watier L,Guillemot D,Delarocque-Astagneau E

    更新日期:2015-03-15 00:00:00

  • Legionnaire's disease presenting as bilateral central scotomata: a case report.

    abstract:BACKGROUND:Legionnaire's disease is one of the major causes of community-acquired pneumonia and is occasionally complicated by neurological symptoms. However, reports of ocular lesions due to Legionnaire's disease are limited. CASE PRESENTATION:We report the case of a patient with Legionnaire's disease presenting as b...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05715-y

    authors: Yamada S,Kitajima T,Marumo S,Fukui M

    更新日期:2021-01-07 00:00:00

  • An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis.

    abstract:BACKGROUND:Specific land cover types and activities have been correlated with Trypanosoma brucei rhodesiense distributions, indicating the importance of landscape for epidemiological risk. However, methods proposed to identify specific areas with elevated epidemiological risk (i.e. where transmission is more likely to ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-316

    authors: Wardrop NA,Fèvre EM,Atkinson PM,Kakembo A,Welburn SC

    更新日期:2012-11-21 00:00:00

  • Association between early bacterial carriage and otitis media in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia: a cohort study.

    abstract:BACKGROUND:Streptococcus pneumoniae (Pnc), nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are the most important bacterial pathogens associated with otitis media (OM). Previous studies have suggested that early upper respiratory tract (URT) bacterial carriage may increase risk of subsequent ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-366

    authors: Sun W,Jacoby P,Riley TV,Bowman J,Leach AJ,Coates H,Weeks S,Cripps A,Lehmann D,Kalgoorlie Otitis Media Research Project Team.

    更新日期:2012-12-21 00:00:00

  • Multi-complexity measures of heart rate variability and the effect of vasopressor titration: a prospective cohort study of patients with septic shock.

    abstract:BACKGROUND:Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS:We studied patients with...

    journal_title:BMC infectious diseases

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12879-016-1896-1

    authors: Brown SM,Sorensen J,Lanspa MJ,Rondina MT,Grissom CK,Shahul S,Mathews VJ

    更新日期:2016-10-10 00:00:00

  • Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis.

    abstract:INTRODUCTION:Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Ethiopia. Although evidences are available on the prevalence and associated factors of late presenta...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12879-019-4156-3

    authors: Belay GM,Endalamaw A,Ayele AD

    更新日期:2019-06-17 00:00:00

  • Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era.

    abstract:BACKGROUND:The incidence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) has risen dramatically in the U.S., particularly among children. Although Streptococcus pneumoniae colonization has been inversely associated with S. aureus colonization in unvaccinated children, this and other risk fact...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-110

    authors: Lee GM,Huang SS,Rifas-Shiman SL,Hinrichsen VL,Pelton SI,Kleinman K,Hanage WP,Lipsitch M,McAdam AJ,Finkelstein JA

    更新日期:2009-07-11 00:00:00

  • Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study.

    abstract:BACKGROUND:Temporary increases in plasma HIV RNA ('blips') are common in HIV patients on combination antiretroviral therapy (cART). Blips above 500 copies/mL have been associated with subsequent viral rebound. It is not clear if this relationship still holds when measurements are made using newer more sensitive assays....

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1120-8

    authors: Young J,Rickenbach M,Calmy A,Bernasconi E,Staehelin C,Schmid P,Cavassini M,Battegay M,Günthard HF,Bucher HC,Swiss HIV Cohort Study.

    更新日期:2015-09-21 00:00:00

  • Impact of daily versus weekly service of infectious diseases consultation on hospital antimicrobial consumption: a retrospective study.

    abstract:BACKGROUND:To verify whether a daily service of Infectious Diseases consultation (ID-cons) is more effective than a weekly service in reducing antibiotic (ATB) consumption without worsening of clinical outcomes. METHODS:Two-year observational analysis of the ID-cons provided in a hospital setting in Milan, Italy. ID-c...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05550-1

    authors: Cona A,Gazzola L,Viganò O,Bini T,Marchetti GC,d'Arminio Monforte A

    更新日期:2020-11-07 00:00:00

  • Towards accurate exclusion of neonatal bacterial meningitis: a feasibility study of a novel 16S rDNA PCR assay.

    abstract:BACKGROUND:PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of cerebro-spinal fluid (CSF). The assay's potential for accurate, fast and inexpensive discrimination of bacteria-free CSF makes it an ideal adjunct for confident exclusio...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05160-x

    authors: Abelian A,Mund T,Curran MD,Savill SA,Mitra N,Charan C,Ogilvy-Stuart AL,Pelham HRB,Dear PH

    更新日期:2020-06-22 00:00:00

  • Infectious agents is a risk factor for myxomatous mitral valve degeneration: A case control study.

    abstract:BACKGROUND:The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2387-8

    authors: Tiveron MG,Pomerantzeff PMA,de Lourdes Higuchi M,Reis MM,de Jesus Pereira J,Kawakami JT,Ikegami RN,de Almeida Brandao CM,Jatene FB

    更新日期:2017-04-21 00:00:00

  • Onychomadesis and potential association with HFMD outbreak in a kindergarten in Hubei province, China, 2017.

    abstract:BACKGROUND:In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. METHODS:The case definition was that a child with onychomadesis or transverse ridging (Beau's line) in fingernails and toenails without ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4560-8

    authors: Li D,Wu Y,Xing X,Huang J,Mao A,Liu T,Rao P,Qin W,Zhang L,Feng L,Gao S,Guan X

    更新日期:2019-11-26 00:00:00

  • Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection.

    abstract:BACKGROUND:HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes of this activation, however, are incompletely understood. We investigated the activation status of CD4+ T cells specific for chronic herpes viruses and the non-persistent antigen tetanus toxoi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-100

    authors: Smith MZ,Bastidas S,Karrer U,Oxenius A

    更新日期:2013-02-25 00:00:00

  • Gastro-enteritis outbreak among Nordic patients with psoriasis in a health centre in Gran Canaria, Spain: a cohort study.

    abstract:BACKGROUND:Between November 2 and 10, 2002 several patients with psoriasis and personnel staying in the health centre in Gran Canaria, Spain fell ill with diarrhoea, vomiting or both. Patient original came from Norway, Sweden and Finland. The patient group was scheduled to stay until 8 November. A new group of patients...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-4-45

    authors: Eriksen HM,Guerin PJ,Nygård K,Hjertqvist M,de Jong B,Rose AM,Kuusi M,Durr U,Rojas AG,Mør C,Aavitsland P

    更新日期:2004-10-29 00:00:00

  • A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918-1919.

    abstract:BACKGROUND:In the spring of 1918, the "War to End All Wars", which would ultimately claim more than 37 million lives, had entered into its final year and would change the global political and economic landscape forever. At the same time, a new global threat was emerging and would become one of the most devastating glob...

    journal_title:BMC infectious diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1186/s12879-019-3750-8

    authors: Nickol ME,Kindrachuk J

    更新日期:2019-02-06 00:00:00

  • Incidence, risk factors, and outcomes of Fusobacterium species bacteremia.

    abstract:BACKGROUND:Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical o...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-264

    authors: Afra K,Laupland K,Leal J,Lloyd T,Gregson D

    更新日期:2013-06-05 00:00:00

  • Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users.

    abstract:BACKGROUND:Anthrax had become extremely rare in Europe, but in 2010 an outbreak of anthrax among heroin users in Scotland increased awareness of contaminated heroin as a source of anthrax. We present the first two Danish cases of injectional anthrax and discuss the clinical presentations, which included both typical an...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-408

    authors: Russell L,Pedersen M,Jensen AV,Søes LM,Hansen AB

    更新日期:2013-09-03 00:00:00

  • Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners.

    abstract:BACKGROUND:Globally, prison inmates are a high-risk population for tuberculosis (TB), but the specific drivers of disease and impact of mass screening interventions are poorly understood. METHODS:We performed a prospective cohort study to characterize the incidence and risk factors for tuberculosis infection and disea...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1868-5

    authors: Paião DS,Lemos EF,Carbone AD,Sgarbi RV,Junior AL,da Silva FM,Brandão LM,Dos Santos LS,Martins VS,Simionatto S,Motta-Castro AR,Pompílio MA,Urrego J,Ko AI,Andrews JR,Croda J

    更新日期:2016-10-03 00:00:00

  • Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients.

    abstract:BACKGROUND:Fungal infections are diagnosed increasingly often in patients affected by hematological diseases and their mortality has remained high. The recent development of new antifungal drugs gives the clinician the possibility to assess the combination of antifungal drugs with in-vitro or in animal-model synergisti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-28

    authors: Cesaro S,Giacchino M,Locatelli F,Spiller M,Buldini B,Castellini C,Caselli D,Giraldi E,Tucci F,Tridello G,Rossi MR,Castagnola E

    更新日期:2007-04-18 00:00:00

  • Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia.

    abstract:BACKGROUND:This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children in Ethiopia. METHODS:We model the mosquito abundance and time to malaria data jointly in a Bayesian framework. RE...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2496-4

    authors: Belay DB,Kifle YG,Goshu AT,Gran JM,Yewhalaw D,Duchateau L,Frigessi A

    更新日期:2017-06-12 00:00:00

  • Evidence for an enterovirus as the cause of encephalitis lethargica.

    abstract:BACKGROUND:The epidemic of encephalitis lethargica (EL), called classical EL, was rampant throughout the world during 1917-1926, affecting half a million persons. The acute phase was lethal for many victims. Post-encephalitic parkinsonism (PEP) affected patients for decades. Our purpose was to investigate the cause of ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-136

    authors: Dourmashkin RR,Dunn G,Castano V,McCall SA

    更新日期:2012-06-20 00:00:00

  • Molecular epidemiology of Hepatitis B virus genotypes in Pakistan.

    abstract:BACKGROUND:Eight genotypes of Hepatitis B virus designated A-H, have been known but in Pakistan, no such data is available on the prevalent HBV genotypes. Therefore, the subject study was conducted to determine HBV genotypes in the indigenous Pakistani population. METHODS:A total of 690 individuals were enrolled for H...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-115

    authors: Alam MM,Zaidi SZ,Malik SA,Shaukat S,Naeem A,Sharif S,Angez M,Butt JA

    更新日期:2007-10-08 00:00:00

  • Renal impairment in a rural African antiretroviral programme.

    abstract:BACKGROUND:There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofov...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-143

    authors: Franey C,Knott D,Barnighausen T,Dedicoat M,Adam A,Lessells RJ,Newell ML,Cooke GS

    更新日期:2009-08-28 00:00:00