Abstract:
BACKGROUND:The management of disseminated cysticercosis is unclear and largely considered hazardous. The role of albendazole remains controversial in such patients. METHODS:A tertiary care, University hospital-based prospective intervention study was conducted from December 2015 to December 2017. Patients with disseminated cysticercosis, defined as the presence of multiple viable neurocysticerci (≥ 3) in the brain along with involvement of an additional extra site, were included in the study. Patients with cysticercal encephalitis were excluded. A detailed evaluation, including ophthalmoscopy, ocular B scans, ultrasound abdomen, and X-rays were done. Albendazole was administered at a dose of 15 mg/kg/day in 3 cycles of 28 days each. All patients were also given adjuvant corticosteroids and anti-epileptic drugs. Clinical and radiological follow up was carried out at a difference of 3 months between each treatment cycle. For radiological quantification, lesions were counted at 10 pre-specified levels. Statistical analysis was done to estimate the difference in seizure frequency and lesion load. RESULTS:Twenty-nine patients (21 with > 20 lesions; 8 with ≤ 20 lesions) were given albendazole as per the protocol. There was a significant reduction in the occurrence of seizures (P < 0.001) and headache (P < 0.001). A significant reduction in lesion load from baseline to third follow-up was seen in the estimations done at different levels (P < 0.001). No patient developed serious side-effect warranting cessation of therapy. CONCLUSION:Cyclical use of albendazole appears efficacious in treating disseminated cysticercosis. The method of quantification described may be used in future studies for objective assessment. TRIAL REGISTRATION:ISRCTN11630542; 28th September 2019; Retrospectively registered.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Pandey S,Malhotra HS,Garg RK,Malhotra KP,Kumar N,Rizvi I,Jain A,Kohli N,Verma R,Sharma P,Uniyal R,Pandey Sdoi
10.1186/s12879-020-4891-5subject
Has Abstractpub_date
2020-03-14 00:00:00pages
220issue
1issn
1471-2334pii
10.1186/s12879-020-4891-5journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Implant-related infections, including those of peri-prosthetic joint (PJIs), osteosynthesis and other biomaterials, are biofilm-related. Pathogen identification is considered the diagnostic benchmark; however, the presence of bacterial biofilms makes pathogen detection with traditional microbiological techni...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3050-8
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Influenza viruses are a major cause of morbidity and mortality worldwide. Vaccination remains a powerful tool for preventing or mitigating influenza outbreaks. Yet, vaccine supplies and daily administration capacities are limited, even in developed countries. Understanding how such constraints can alter the ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-207
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information on XDR TB is available. Hence, the eval...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3009-9
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1475-5
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abstract:BACKGROUND:Cutaneous leishmaniasis (CL) is an important public health problem in Brazil and in several tropical regions of the world. In the Americas, Brazil is the country with the highest number of registered cases. In Brazil, the state of Minas Gerais has the highest number of cases in the southeastern region. In th...
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journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
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更新日期:2020-03-04 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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doi:10.1186/1471-2334-4-37
更新日期:2004-09-21 00:00:00
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更新日期:2013-11-05 00:00:00
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更新日期:2019-05-16 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-06-12 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2012-12-21 00:00:00
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pub_type: 杂志文章
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更新日期:2015-06-18 00:00:00
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pub_type: 杂志文章
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