Blood and alveolar lymphocyte subsets in pulmonary cytomegalovirus infection after lung transplantation.


BACKGROUND:Cytomegalovirus (CMV) pneumonitis has been shown to be associated with lymphocytic alveolitis after lung transplantation. In the present study, we investigated a series of bronchoalveolar (BAL) and blood samples, collected in the absence of rejection or acute infectious episodes. in order -1: to evaluate intra-alveolar cell population changes concomitant with CMV replication and -2: to reappraise the value of cell population analysis in the management of patients after lung transplantation. METHODS:We used flow cytometry to investigate modifications of lymphocyte subpopulations related to pulmonary cytomegalovirus infections in blood and BAL samples from a series of 13 lung transplant recipients. After exclusion of samples obtained during pulmonary rejection, bronchiolitis obliterans or acute bacterial infection, 48 blood and BAL samples were retained for analysis: 17 were CMV positive by shell-vial assay and 31 were CMV negative in blood and BAL. RESULTS:Our results demonstrate that pulmonary CMV infection is associated with a significant increase in the total lymphocyte population in BAL samples, but with minor modifications of the various lymphocyte subpopulations and a significantly higher absolute number of B lymphocytes in blood samples. CONCLUSIONS:Cytomegalovirus pulmonary infection is accompanied by only minor changes in BAL lymphocyte subpopulations. The study of BAL lymphocyte subpopulations therefore appears to be of limited clinical value in the diagnosis of pulmonary CMV infection. However, increased blood B-lymphocytes seems to be a clinical feature associated with CMV infection.


BMC Infect Dis


BMC infectious diseases


Stéphan F,Bernaudin JF,Cesari D,Fajac A,Grenet D D,Caubarrere I,Stern M





Has Abstract


2001-01-01 00:00:00








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    abstract:BACKGROUND:Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS:This mult...

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    pub_type: 杂志文章,多中心研究


    authors: Katsurada N,Suzuki M,Aoshima M,Yaegashi M,Ishifuji T,Asoh N,Hamashige N,Abe M,Ariyoshi K,Morimoto K,Adult Pneumonia Study Group-Japan.

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  • The general status of patients and limited physical activity as risk factors of Methicillin-resistant Staphylococcus aureus occurrence in long-term care facilities residents in Krakow, Poland.

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    pub_type: 杂志文章,多中心研究


    authors: Romaniszyn D,Pobiega M,Wójkowska-Mach J,Chmielarczyk A,Gryglewska B,Adamski P,Heczko PB,Ochońska D,Bulanda M

    更新日期:2014-05-18 00:00:00

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    abstract:BACKGROUND:Australia is developing a chlamydia screening program. This study aimed to determine the attitudes of young women to the introduction of chlamydia screening in Australian General Practice. METHODS:In-depth face-to-face interviews with 24 young women from across Victoria, Australia, attending a randomly sele...

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    pub_type: 杂志文章


    authors: Pavlin NL,Parker R,Fairley CK,Gunn JM,Hocking J

    更新日期:2008-05-09 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2016-04-13 00:00:00

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    pub_type: 杂志文章


    authors: Garneau JR,Valiquette L,Fortier LC

    更新日期:2014-01-15 00:00:00

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    pub_type: 杂志文章


    authors: Nyakarahuka L,Schafer IJ,Balinandi S,Mulei S,Tumusiime A,Kyondo J,Knust B,Lutwama J,Rollin P,Nichol S,Shoemaker T

    更新日期:2020-07-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2016-09-19 00:00:00

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    pub_type: 杂志文章


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    更新日期:2008-01-23 00:00:00

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    pub_type: 杂志文章


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    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Yimer S,Bjune G,Alene G

    更新日期:2005-12-12 00:00:00

  • Neonatal septicemia caused by a rare pathogen: Raoultella planticola - a report of four cases.

    abstract:BACKGROUND:Raoultella planticola(R.planticola) is a very rare opportunistic pathogen and sometimes even associated with fatal infection in pediatric cases. Recently,the emergence of carbapenem resistance strains are constantly being reported and a growing source of concern for pediatricians. CASE PRESENTATION:We repor...

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    pub_type: 杂志文章


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    更新日期:2020-09-16 00:00:00

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    pub_type: 杂志文章


    authors: Cousin VL,Lambert K,Trabelsi S,Galetto-Lacour A,Posfay-Barbe KM,Wildhaber BE,McLin VA

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    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Lambertsen L,Kerrn MB

    更新日期:2010-09-24 00:00:00

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    pub_type: 杂志文章


    authors: Sutcliffe CG,Mutanga J,Moyo N,Agarwal AK,Schue JL,Hamahuwa M,Palamountain KM,Fisher MJ,Elghanian R,Thuma PE,Moss WJ

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    abstract:BACKGROUND:Direct immunofluorescence assays (DFA) are a rapid and inexpensive method for the detection of respiratory viruses and may therefore be used for surveillance. Few epidemiological studies have been published based solely on DFA and none included respiratory picornaviruses and human metapneumovirus (hMPV). We ...

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    pub_type: 杂志文章


    authors: Sadeghi CD,Aebi C,Gorgievski-Hrisoho M,Mühlemann K,Barbani MT

    更新日期:2011-02-07 00:00:00

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    更新日期:2018-11-29 00:00:00

  • Is aging raw cattle urine efficient for sampling Anopheles arabiensis Patton?

    abstract:BACKGROUND:To ensure sustainable routine surveillance of mosquito vectors, simple, effective and ethically acceptable tools are required. As a part of that, we evaluated the efficiency of resting boxes baited with fresh and aging cattle urine for indoor and outdoor sampling of An. arabiensis in the lower Moshi rice irr...

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    abstract:BACKGROUND:Early insights into the timing of the start, peak, and intensity of the influenza season could be useful in planning influenza prevention and control activities. To encourage development and innovation in influenza forecasting, the Centers for Disease Control and Prevention (CDC) organized a challenge to pre...

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    pub_type: 杂志文章


    authors: Biggerstaff M,Alper D,Dredze M,Fox S,Fung IC,Hickmann KS,Lewis B,Rosenfeld R,Shaman J,Tsou MH,Velardi P,Vespignani A,Finelli L,Influenza Forecasting Contest Working Group.

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    abstract:BACKGROUND:Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-...

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    pub_type: 杂志文章,meta分析


    authors: Guo P,Liu S,Sun X,Xu L

    更新日期:2019-08-30 00:00:00

  • Detection of sexually transmitted infection and human papillomavirus in negative cytology by multiplex-PCR.

    abstract:BACKGROUND:The aim of this study was to determine the prevalence of human papillomavirus (HPV) and 15 species that cause sexually transmitted infections (STIs) in negative cytology. In addition, we compared the diagnostic performance of multiplex polymerase chain reaction (PCR) with widely available techniques used to ...

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    pub_type: 杂志文章


    authors: Shim HS,Noh S,Park AR,Lee YN,Kim JK,Chung HJ,Kang KS,Cho NH

    更新日期:2010-09-28 00:00:00

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    pub_type: 杂志文章


    authors: Franck C,Seddon JA,Hesseling AC,Schaaf HS,Skinner D,Reynolds L

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    pub_type: 杂志文章,多中心研究


    authors: Zilberberg MD,Chaudhari P,Nathanson BH,Campbell RS,Emons MF,Fiske S,Hays HD,Shorr AF

    更新日期:2012-07-11 00:00:00

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    pub_type: 杂志文章


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    更新日期:2013-06-05 00:00:00

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    pub_type: 杂志文章


    authors: Baldo V,Cocchio S,Buja A,Baldovin T,Furlan P,Bertoncello C,Saia M

    更新日期:2013-10-05 00:00:00

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    journal_title:BMC infectious diseases

    pub_type: 杂志文章


    authors: Daw MA,El-Bouzedi A,In association with Libyan Study Group of Hepatitis & HIV.

    更新日期:2014-01-09 00:00:00

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    pub_type: 杂志文章


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    更新日期:2020-03-12 00:00:00

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    pub_type: 杂志文章


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    更新日期:2019-05-14 00:00:00

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    pub_type: 历史文章,杂志文章,评审


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    更新日期:2019-02-06 00:00:00