Abstract:
BACKGROUND:The effectiveness of Long-Lasting Insecticidal Nets and Indoor Residual Spraying in malaria vector control is threatened by vector resistance to insecticides. Knowledge of mosquito habitats and patterns of insecticide resistance would facilitate the development of appropriate vector control strategies. Therefore, we investigated An. coluzzii larval habitats and resistance to insecticides in the Manoka rural island area compared with the Youpwe suburban inland area, in Douala VI and II districts respectively. METHODS:Anopheline larvae and pupae were collected from open water bodies in December 2013 and April 2014 and reared until adult emergence. Two to four day old emerging females were morphologically identified as belonging to the An. gambiae complex and used for WHO susceptibility tests with 4 % DDT, 0.75 % permethrin, and 0.05 % deltamethrin, with or without piperonyl butoxide (PBO) synergist. Control and surviving specimens were identified down to the species using a PCR-RFLP method. Survivors were genotyped for kdr L1014 mutations using Hot Oligonucleotide Ligation Assay. RESULTS:In both study sites, ponds, residual puddles, boats, and drains were identified as the major An. gambiae s.l. larval habitats. A total of 1397 females, including 784 specimens from Manoka and 613 from Youpwe, were used for resistance testing. The two mosquito populations displayed resistance to DDT, permethrin and deltamethrin, with variable mortality rates from 1 % to 90 %. The knock-down times were also significantly increased (at least 2.8 fold). Pre-exposure of mosquitoes to PBO did not impact on their mortality to DDT, conversely the mortality rates to permethrin and deltamethrin were significantly increased (7.56 ≤ X(2) ≤ 48.63, df = 1, p < 0.01), suggesting involvement of P450 oxidases in pyrethroid resistance. A subsample of 400 An. gambiae s.l. specimens including 280 control and 120 survivors from bioassays were all found to be An. coluzzii species. Only the kdr 1014 F mutation was found in survivors, with 88.5 % (N = 76) and 75 % (N = 44) frequencies in Youpwe and Manoka respectively. CONCLUSION:This is the first report of An. coluzzii resistance to insecticides in an insular area in Cameroon. Since permanent larval habitats have been identified, larval source management strategies may be trialed in this area as complementary vector control interventions.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Etang J,Mbida Mbida A,Ntonga Akono P,Binyang J,Eboumbou Moukoko CE,Lehman LG,Awono-Ambene P,Talipouo A,Ekoko Eyisab W,Tagne D,Tchoffo R,Manga L,Mimpfoundi Rdoi
10.1186/s12879-016-1542-ysubject
Has Abstractpub_date
2016-05-20 00:00:00pages
217issn
1471-2334pii
10.1186/s12879-016-1542-yjournal_volume
16pub_type
杂志文章abstract:BACKGROUND:This randomized controlled trial aimed to evaluate whether the serum procalcitonin (PCT) level can be utilized to guide the use of antibiotics in the treatment of acute exacerbations of asthma. METHODS:A total of 293 consecutive patients with suspected asthma attacks from February 2005 to July 2010 particip...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-13-596
更新日期:2013-12-17 00:00:00
abstract:BACKGROUND:To reach non-participants, reluctant to undergo clinician-based cervical cancer screening and vaginal self-sampling, urine collection for high-risk human papillomavirus detection (hrHPV) may be valuable. Using two hrHPV DNA assays, we evaluated the concordance of hrHPV positivity in urine samples in comparis...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05663-7
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:Dengue has global importance as a dreaded arboviral infection. It has 4 serotypes of epidemiological imporatnce. The classification denotes two clinical spectrums- dengue fever (DF) and dengue haemorragic fever (DHF). Most cases are stereotype and amenable to fluid resuscitation. However, unusual manifestati...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3596-5
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. METHODS:The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain react...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0841-z
更新日期:2015-02-26 00:00:00
abstract:BACKGROUND:Airborne fungi play an important role in causing allergy and infections in susceptible people. Identification of these fungi, based on morphological characteristics, is time-consuming, expertise-demanding, and could be inaccurate. METHODS:We developed an oligonucleotide array that could accurately identify ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-91
更新日期:2011-04-13 00:00:00
abstract:BACKGROUND:Men who have sex with men (MSM) bear a high burden of syphilis infection. Expanding syphilis testing to improve timely diagnosis and treatment is critical to improve syphilis control. However, syphilis testing rates remain low among MSM, particularly in low- and middle-income countries. We describe the proto...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-020-05188-z
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Soft tissue or skin infections due to nontuberculous mycobacteria (NTM) have been reported frequently and are mostly associated with trauma or cosmetic interventions like plastic surgery. However, infection with NTM as a result of a dental procedure have rarely been described and the lack of clinical suspici...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05015-5
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. METHODS:The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05607-1
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Dengue, a viral disease transmitted by Aedes mosquitoes, is an important public health concern throughout Thailand. Climate variables are potential predictors of dengue transmission. Associations between climate variables and dengue have usually been performed on large-scale first-level national administrati...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4379-3
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:Viral load (VL) testing is being scaled up in resource-limited settings. However, not all commercially available VL testing methods have been evaluated under field conditions. This study is one of a few to evaluate the Biocentric platform for VL quantification in routine practice in Sub-Saharan Africa. METH...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3474-1
更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:Fear of TB infection is rooted in historical and social memories of the disease, marked by stigma, segregation and exclusion. Healthcare workers (HCWs) face these same fears today, and even seek to hide their TB status when infected. This study sought to investigate factors associated with HCWs fears of acqu...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-019-4115-z
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:HIV-uninfected infants born to HIV-infected mothers (HIV-exposed uninfected, HEU) have been described to have immune alterations as compared to unexposed infants. This study sought to characterize T-cell populations after birth in HEU infants and unexposed infants living in a semirural area in southern Mozam...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0766-6
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:To verify whether a daily service of Infectious Diseases consultation (ID-cons) is more effective than a weekly service in reducing antibiotic (ATB) consumption without worsening of clinical outcomes. METHODS:Two-year observational analysis of the ID-cons provided in a hospital setting in Milan, Italy. ID-c...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05550-1
更新日期:2020-11-07 00:00:00
abstract:BACKGROUND:Recent data have shown that HTLV-1 is prevalent among HIV positive patients in Mozambique, although the impact of HTLV-1 infection on HIV disease progression remains controversial. Our aim was to determine the phenotypic profile of T lymphocytes subsets among Mozambican patients co-infected by HIV and HTLV-1...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-211
更新日期:2009-12-22 00:00:00
abstract:BACKGROUND:Chronic Q fever usually presents as endocarditis or endovascular infection. We investigated whether 18F-FDG PET/CT and echocardiography were able to detect the localization of infection. Also, the utility of the modified Duke criteria was assessed. METHODS:Fifty-two patients, who had an IgG titre of ≥ 1024...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-413
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:The preferred regimen for HIV post-exposure prophylaxis (PEP) is based mainly on safety and tolerability because it is given to immunocompetent people without HIV infection for a limited time (28 days). The frequency of adverse events (AEs) may be > 60%. Although AEs are generally not severe, they can lead t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2056-3
更新日期:2016-11-29 00:00:00
abstract:BACKGROUND:Regardless of chronic treatment with antiretroviral therapy (ART), the switching rate for ART regarding anchor drugs has not been articulated in real-world clinical-settings in Japan. We assessed switch rates and time-to-switch of ART regimens according to anchor drug classes (integrase strand transfer inhib...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4129-6
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:Clinical outcomes of spontaneous bacterial peritonitis (SBP) due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have not been adequately investigated. METHODS:We conducted a retrospective matched case-control study to evaluate the outcomes of SBP due to ESBL-...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-41
更新日期:2009-04-12 00:00:00
abstract:BACKGROUND:Filamentous basidiomycetes are mainly considered to be respiratory tract colonizers but the clinical significance of their isolation in a specimen is debatable. Hormographiella aspergillata was first reported as a human pathogen in 1971. We discuss the role of this mold as a pathogen or colonizer and give an...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-020-05679-z
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:Even though remarkable progress for diagnostics of pulmonary TB has been made, it is still a challenge to establish a definitive diagnosis for extrapulmonary TB (EPTB) in clinical practice. Among all the presentations of EPTB, cold abscesses are unusual and deceptive, which are often reported in the chest wa...
journal_title:BMC infectious diseases
pub_type: 杂志文章,评审
doi:10.1186/s12879-020-05137-w
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLR) 7 and 8 are important in single-stranded viral RNA recognition and may play a role in HIV infection and disease progression. We analyzed TLR7/8 expression and signaling in monocytes from HIV-infected and uninfected subjects to investigate a pathway with new potential for the suppres...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-5
更新日期:2012-01-14 00:00:00
abstract:BACKGROUND:The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. METHODS:We performed a prospective multicentre study in inmates from 25 Spanis...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-015-1102-x
更新日期:2015-08-19 00:00:00
abstract:BACKGROUND:Young people are disproportionately affected by sexually transmissible infections in Australia but face barriers to accessing sexual health services, including concerns over confidentiality and, for some, geographic remoteness. A possible innovation to increase access to services is the use of telemedicine. ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-285
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-2-22
更新日期:2002-10-04 00:00:00
abstract:BACKGROUND:Chronic osteomyelitis due to direct bone trauma or vascular insufficiency is a frequent problem in orthopaedic surgery. In contrast, acute haematogenous osteomyelitis represents a rare entity that almost exclusively affects prepubescent children or immunodeficient adults. CASE PRESENTATION:In this article, ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-266
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also a...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2567-6
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:To explore the kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19. METHODS:This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 designated hospitals of Zhoushan, Zhejia...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05549-8
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The prevalence of diabetes mellitus continues to inexorably rise in the United States and throughout the world. Lower limb amputations are a devastating comorbid complication of diabetes mellitus. Osteomyelitis increases the risk of amputation fourfold and commonly presages death. Antimicrobial therapy for d...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-019-4751-3
更新日期:2020-01-08 00:00:00
abstract:BACKGROUND:Amphotericin-induced phlebitis is a common infusion-related reaction in patients managed for cryptococcal meningitis. High-quality nursing care is critical component to successful cryptococcosis treatment. We highlight the magnitude and main approaches in the management of amphotericin-induced phlebitis and ...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-019-4209-7
更新日期:2019-06-26 00:00:00
abstract:BACKGROUND:Data for predicting which patients with pandemic influenza A (H1N1) infection are likely to run a complicated course are sparse. We retrospectively studied whether the admission serum C-reactive protein (CRP) levels can serve as a predictor of illness severity. METHODS:Included were all consecutive adult pa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-288
更新日期:2010-10-04 00:00:00