Hormographiella aspergillata: an emerging basidiomycete in the clinical setting? A case report and literature review.

Abstract:

BACKGROUND:Filamentous basidiomycetes are mainly considered to be respiratory tract colonizers but the clinical significance of their isolation in a specimen is debatable. Hormographiella aspergillata was first reported as a human pathogen in 1971. We discuss the role of this mold as a pathogen or colonizer and give an update on diagnostic tools and in vitro antifungal susceptibility. CASE PRESENTATION:We identified three cases of H. aspergillata with respiratory symptoms in a short period of time. One invasive infection and two colonizations were diagnosed. Culture supernatants showed that H. aspergillata can produce galactomannan and β-D-glucan but not glucuronoxylomannan. For the first time, isavuconazole susceptibility was determined and high minimum inhibitory concentrations (MICs) were found. Liposomal amphotericin B and voriconazole have the lowest MICs. CONCLUSION:To date, 22 invasive infections involving H. aspergillata have been reported. On isolation of H. aspergillata, its pathogenic potential in clinical settings can be tricky. Molecular identification and antifungal susceptibility testing are essential considering high resistance against several antifungal therapies.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Moniot M,Lavergne RA,Morel T,Guieze R,Morio F,Poirier P,Nourrisson C

doi

10.1186/s12879-020-05679-z

subject

Has Abstract

pub_date

2020-12-11 00:00:00

pages

945

issue

1

issn

1471-2334

pii

10.1186/s12879-020-05679-z

journal_volume

20

pub_type

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