Abstract:
BACKGROUND:To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). METHODS:Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disorders. RESULTS:Male to female ratio was similar in the two groups (50/9 vs. 16/4, P = 0.62). Mean age was 67 +/- 10.8 years and 52 +/- 20.3 years in the case and control groups, respectively (P = 0.6). Of the 59 tissue specimens with diagnosis of transitional cell carcinoma, HPV DNA was detected in 21 (35.6%) samples, while it was present in only one sample (5%) in the control group (P = 0.008). HPV18 was the most common type of virus with the incidence rate of 17/21(81%). CONCLUSION:HPV might play a causative role in transitional cell carcinoma of bladder in our geographic area.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Barghi MR,Hajimohammadmehdiarbab A,Moghaddam SM,Kazemi Bdoi
10.1186/1471-2334-5-102keywords:
subject
Has Abstractpub_date
2005-11-08 00:00:00pages
102issn
1471-2334pii
1471-2334-5-102journal_volume
5pub_type
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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