Abstract:
BACKGROUND:Individuals who focused on calorie counting lost more weight than those who focused on increasing vegetable and fruit (V&F) intake in a weight loss program. We now present serum carotenoid data (biomarkers of V&F intake) from both groups and test whether these biomarkers correlate with changes in weight and body fat. DESIGN:Sixty obese volunteers were randomized to one of the following weight loss programs: 500 kcal per day reduction (Reduction) or a focus on consuming eight vegetables per day and 2-3 fruits per day (HiVeg). Volunteers in the Reduction group were 36.8±10.3 years with a body mass index of 33.5; 83% were white, 17% chose not to report race; 70% were not Hispanic or Latino, 13% were Hispanic or Latino and 17% chose not to report ethnicity. Volunteers in the HiVeg group were 30.4±6.6 years with a body mass index of 33.2: 74% white, 11% Asian, 5% black or African American, 5% multiracial and 5% chose not to report race; 89% were not Hispanic or Latino, 5% were Hispanic or Latino and 5% chose not to report ethnicity. Subjects were taught basic nutrition principles, received breakfast and lunch 5 days per week for 3 months, meals 2 days per week during month 4, then regular phone calls to month 12. RESULTS:Total serum carotenoid concentrations increased from baseline to 3 months and remained elevated at 12 months, but there was no difference between groups. Changes in weight, fat and % fat correlated negatively with serum carotenoid concentrations. CONCLUSION:Increased serum carotenoids (a biomarker for V&F intake) correlated with improved weight and fat loss indicating that increased V&F consumption is an appropriate strategy for weight loss. However, in light of the fact that the Reduction group lost more weight, the consumption of increased V&F for the purpose of weight loss should happen within the context of reducing total caloric intake.
journal_name
Nutr Diabetesjournal_title
Nutrition & diabetesauthors
Whigham LD,Valentine AR,Johnson LK,Zhang Z,Atkinson RL,Tanumihardjo SAdoi
10.1038/nutd.2012.22subject
Has Abstractpub_date
2012-10-01 00:00:00pages
e48issn
2044-4052pii
nutd201222journal_volume
2pub_type
杂志文章abstract::Human obesity has evolved into a global epidemic. Interestingly, a similar trend has been observed in many animal species, although diet composition, food availability and physical activity have essentially remained unchanged. This suggests a common factor-potentially an environmental factor affecting all species. Coi...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.2
更新日期:2012-03-05 00:00:00
abstract:BACKGROUND/OBJECTIVES:The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS:To determine if changes in the mother's diet and adip...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0027-z
更新日期:2018-04-25 00:00:00
abstract:BACKGROUND:The global prevalence of diabetes is high and rapidly increasing. Some previous studies have found that vegetarians might have a lower risk of diabetes than non-vegetarians. OBJECTIVE:We examined the association between vegetarianism and risk of hospitalisation or death with diabetes in a large, prospective...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0074-0
更新日期:2019-02-25 00:00:00
abstract:BACKGROUND/OBJECTIVES:Neuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.45
更新日期:2015-01-19 00:00:00
abstract::For convenience, health practitioners and clinicians are inclined to classify people/patients as overweight or obese based on body mass index (BMI) cutoff points of 25 and 30 kg m(-2) respectively, irrespective of age and gender. The purpose of the current study was to identity whether, for the same levels of adiposit...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.36
更新日期:2015-11-30 00:00:00
abstract:OBJECTIVE:To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. DESIGN:Cross-sectional study of a random population sample. PARTICIPANTS:A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional Sou...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.20
更新日期:2012-01-16 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted hormone that is important for controlling body weight, we hypothesize...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0076-y
更新日期:2019-03-18 00:00:00
abstract::Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-020-0127-4
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evid...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,meta分析
doi:10.1038/s41387-019-0086-9
更新日期:2019-06-05 00:00:00
abstract:OBJECTIVES:The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism. METHODS:Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes were predicted using PharmMapper and analyzed using Kyoto Encyclopedia...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00134-z
更新日期:2020-08-14 00:00:00
abstract::Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially oth...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/nutd.2017.16
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.9
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND/OBJECTIVE:The objective of the study was to provide current estimates of the prevalence and trends of overweight and obesity (OW+OB) in Mexican children and adolescents. SUBJECTS/METHODS:Body mass index objectively measured was analyzed for 37 147 children and adolescents aged 0-19 years obtained in 2012 as...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.52
更新日期:2017-03-13 00:00:00
abstract::Diabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0111-z
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Obesity in the United States is highly prevalent, approaching 60% for black women. We investigated whether nutrition education sessions at the work place added to internet-based wellness information and exercise resources would facilitate weight and fat mass loss in a racially diverse population of overweight...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2013.39
更新日期:2013-12-23 00:00:00
abstract:OBJECTIVE:The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease and have been associated with obesity. The aim of this study was to elucidate differences in gut micr...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.8
更新日期:2011-07-18 00:00:00
abstract:OBJECTIVE:In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has dem...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.49
更新日期:2016-12-12 00:00:00
abstract::Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and d...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2016.19
更新日期:2016-06-06 00:00:00
abstract:OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was n...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2011.4
更新日期:2011-05-23 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Delivery of nutrients directly to the small intestine, either via enteral feeding tube or by gastric bypass surgery, is associated with increased levels of appetite-suppressing and glucoregulatory hormones, including GLP-1, and reduced appetite. Achieving these changes non-invasively using for...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41387-019-0088-7
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:High dietary fibre intakes may protect against obesity by influencing colonic fermentation and the colonic microbiota. Though, recent studies suggest that increased colonic fermentation contributes to adiposity. Diet influences the composition of the gut microbiota. Previous research has not evalu...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.23
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vegetarian diets are inversely associated with diabetes in Westerners but their impact on Asians-whose pathophysiology differ from Westerners-is unknown. We aim to investigate the association between a vegetarian diet, change in dietary patterns and diabetes risk in a Taiwanese Buddhist population...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-018-0022-4
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Aerobic exercise training is known to have beneficial effects on whole-body glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such training are less well understood. The purpose of this study was to determine the effect of aerobic exercise training on splanchnic glucose u...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-019-0090-0
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND/OBJECTIVES:Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy overweight (body mass index (BMI) ≥ 25 kg/m2) or GDM are associated with dietary quality or ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-00129-w
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and ty...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2012.18
更新日期:2012-09-10 00:00:00
abstract:OBJECTIVES:Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of cha...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2014.26
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diab...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0113-x
更新日期:2020-03-20 00:00:00
abstract::Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in patients experiencing end-stage renal disease (ESRD). It includes abnormalities in bone and mineral metabolism and vascular calcification. Hyperphosphatemia is a major risk factor leading to morbidity and mortality in patients with ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章,评审
doi:10.1038/s41387-019-0080-2
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have shown that despite the presence of overt obesity and dyslipidemia in the...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/s41387-020-0112-y
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND/OBJECTIVES:Aging is associated with many physiological alterations such as changes in metabolism, food intake and brain dysfunction. Possible ways to correct age-related brain dysfunction using dietary treatments still remains undeveloped. The aim of our research was to investigate whether long-term dietary ...
journal_title:Nutrition & diabetes
pub_type: 杂志文章
doi:10.1038/nutd.2015.13
更新日期:2015-06-15 00:00:00